Preparation and evaluation of transnasal microemulsion of carbamazepine

Acharya, Sheetal Porecha; Pundarikakshudu, Kilambi; Panchal, Aashish; Lalwani, Anita

doi:10.1016/j.ajps.2013.07.008

Cited by 52 publications

(38 citation statements)

References 15 publications

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“…There was a report showing that the larger negative zeta potential of emulsion droplets was an important factor for emulsion stability. 28 According to the microemulsion stability evaluation by Acharya et al, 29 their microemulsion formulations had very low zeta potential (about -0.11 mV) similar to our result (about -0.26 mV). However, their microemulsion formulations were still stable for long-term storage (3 months) and accelerated condition (centrifugation).…”

supporting

confidence: 78%

Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid

Subongkot¹,

Ngawhirunpat²

2017

IJN

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This study was aimed to develop a novel microemulsion that contained oleth-5 as a surfactant to enhance the oral absorption of all-trans retinoic acid (ATRA). The prepared microemulsion was evaluated for its particle size, shape, zeta potential, in vitro release, in vitro intestinal absorption, intestinal membrane cytotoxicity and stability. The obtained microemulsion was spherical in shape with a particle size of <200 nm and a negative surface charge. The in vitro release of the ATRA-loaded microemulsion was best fit with the zero-order model. This microemulsion significantly improved the intestinal absorption of ATRA. Confocal laser scanning microscopy analysis using a fluorescent dye-loaded microemulsion also confirmed the intestinal absorption result. The intestinal membrane cytotoxicity of the ATRA-loaded microemulsion did not differ from an edible oil (fish oil). Stability testing showed that the ATRA-loaded microemulsion was more stable at 25°C than 40°C.

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supporting

confidence: 78%

Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid

Subongkot¹,

Ngawhirunpat²

2017

IJN

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“…Surfactants can increase et al, 2012;Porter et al, 2008;Rajesh et al, 2010). On the other hand, tween 80 can also act as an enhancer to improve membrane permeation (Acharya et al, 2013). PG is one of the compounds to facilitate drug transportation to the polar lipids of membrane (Trommer and Neubert, 2006).…”

Section: Results and Disscusionmentioning

confidence: 99%

The Dissolution and Diffusion of Furosemide on Self-Nanoemulsifying Drug Delivery System (Snedds)

Wahyuningsih

Sugiyanto²,

Yuswanto³

et al. 2017

Indonesian J. Pharm.

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Furosemide a diuretic exhibits low solubility in water and low bioavailability. The purpose of this study was to determine the effect SNEDDS formation to dissolution and diffusion of furosemide. SNEDDS was made with a mixture of 66% tween 80, 26% propylene glycol, 8% oleic acid and furosemide 40mg/mL. Test for SNEDDS dissolution of the capsules was developed using USP dissolution apparatus I and compared to market products, furosemide suspenssion and furosemide powder. The medium consists of 900mL of Artificial Gastric Fluid (AGF) , phosphate buffer pH 5.8 at 37±0.5°C and stirred with a speed of 100rpm. Diffusion test of SNEDDS furosemide was conducted by using reversed rat intestinal bowel and compared to furosemide suspension and furosemide solution. The SNEDDS formulation could enhance the dissolution and diffusion of furosemide compared to the non-SNEDDS formulation.

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“…And the ratio of solid to liquid lipid was determined by measuring the melting distance of the binary in different ratios [ 41 ]. The ratio of surfactant to co-surfactant was optimized by structuring pseudo-ternary phase diagram [ 55 , 56 ]. Additionally, the ratio of TPL to lipids was investigated using EE% and DL% as indicators.…”

Section: Methodsmentioning

confidence: 99%

Lipid nanoparticles loading triptolide for transdermal delivery: mechanisms of penetration enhancement and transport properties

Yang

Tang

et al. 2018

J Nanobiotechnol

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BackgroundIn recent years, nanoparticles (NPs) including nanostructured lipid carries (NLC) and solid lipid nanoparticles (SLN) captured an increasing amount of attention in the field of transdermal drug delivery system. However, the mechanisms of penetration enhancement and transdermal transport properties of NPs are not fully understood. Therefore, this work applied different platforms to evaluate the interactions between skin and NPs loading triptolide (TPL, TPL-NLC and TPL-SLN). Besides, NPs labeled with fluorescence probe were tracked after administration to investigate the dynamic penetration process in skin and skin cells. In addition, ELISA assay was applied to verify the in vitro anti-inflammatory effect of TPL-NPs.ResultsCompared with the control group, TPL-NPs could disorder skin structure, increase keratin enthalpy and reduce the SC infrared absorption peak area. Besides, the work found that NPs labeled with fluorescence probe accumulated in hair follicles and distributed throughout the skin after 1 h of administration and were taken into HaCaT cells cytoplasm by transcytosis. Additionally, TPL-NLC could effectively inhibit the expression of IL-4, IL-6, IL-8, IFN-γ, and MCP-1 in HaCaT cells, while TPL-SLN and TPL solution can only inhibit the expression of IL-6.ConclusionsTPL-NLC and TPL-SLN could penetrate into skin in a time-dependent manner and the penetration is done by changing the structure, thermodynamic properties and components of the SC. Furthermore, the significant anti-inflammatory effect of TPL-NPs indicated that nanoparticles containing NLC and SLN could serve as safe prospective agents for transdermal drug delivery system.

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Preparation and evaluation of transnasal microemulsion of carbamazepine

Cited by 52 publications

References 15 publications

Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid

Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid

The Dissolution and Diffusion of Furosemide on Self-Nanoemulsifying Drug Delivery System (Snedds)

Lipid nanoparticles loading triptolide for transdermal delivery: mechanisms of penetration enhancement and transport properties

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