2019
DOI: 10.1016/j.ijpharm.2018.11.007
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Preparation and evaluation of trityl-loaded lipid nanocapsules as oxygen sensors for electron paramagnetic resonance oximetry

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Cited by 12 publications
(6 citation statements)
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“…In a previous study, we showed that the covalent binding of cyclic nitrone spin traps to a permethylated β-cyclodextrin moiety could prevent the degradation of corresponding superoxide-derived nitroxide spin adducts by P450 heme in RLM, while only partial protection was afforded by covalent binding to triphenylphosphonium groups [69]. Also, the encapsulation of nitroxides in supramolecular structures, such as liposomes [70], proteinaceous microspheres [71], or lipid nanocapsules [72], previously proposed to protect tetramethyl-substituted nitroxides from ascorbate-induced reduction could also be efficient to protect tetramethyl-substituted nitroxides from P450 metabolism. Caution must be taken, however, as all these strategies are likely to largely impact not only the metabolism but also the distribution and excretion of the probe in vivo.…”
Section: Discussionmentioning
confidence: 99%
“…In a previous study, we showed that the covalent binding of cyclic nitrone spin traps to a permethylated β-cyclodextrin moiety could prevent the degradation of corresponding superoxide-derived nitroxide spin adducts by P450 heme in RLM, while only partial protection was afforded by covalent binding to triphenylphosphonium groups [69]. Also, the encapsulation of nitroxides in supramolecular structures, such as liposomes [70], proteinaceous microspheres [71], or lipid nanocapsules [72], previously proposed to protect tetramethyl-substituted nitroxides from ascorbate-induced reduction could also be efficient to protect tetramethyl-substituted nitroxides from P450 metabolism. Caution must be taken, however, as all these strategies are likely to largely impact not only the metabolism but also the distribution and excretion of the probe in vivo.…”
Section: Discussionmentioning
confidence: 99%
“…The LiNc-BuO-PDMS-PCL has excellent O 2 transparency, O 2 -sensing properties and biocompatibility for continuous oximetry and repeated O 2 measurements in biological systems as well as in clinical settings. Nel et al constructed lipid nanocapsules (LNCs) to encapsulate the hydrophobic spin probes including 4-hydro-TEMPO benzoate (TB) and tetrathiatriarylmethyl free radicals to increase circulation time (Figure c) . Meanwhile, the integration of lipophilic O 2 sensors in O 2 permeable and biocompatible LNCs can improve the sensitivity about 2-fold of spin probes to O 2 , which is ascribed to high O 2 solubility in lipids.…”
Section: Hypoxia Imagingmentioning
confidence: 99%
“…Nel et al constructed lipid nanocapsules (LNCs) to encapsulate the hydrophobic spin probes including 4-hydro-TEMPO benzoate (TB) and tetrathiatriarylmethyl free radicals to increase circulation time (Figure 12c). 371 Meanwhile, the integration of lipophilic O 2 sensors in O 2 permeable and biocompatible LNCs can improve the sensitivity about 2-fold of spin probes to O 2 , which is ascribed to high O 2 solubility in lipids. The results demonstrate that the tetrathiatriarylmethyl-LNCs reacted effectively to alterations in the O 2 environment.…”
Section: Positron Emission Tomography (Pet)mentioning
confidence: 99%
“…LNCs are prepared by an organic solvent free phase-inversion method which adds to their safety. 75 Moreover, LNCs exhibit remarkably high stability and high efficiency for lipophilic drug encapsulation making them an ideal drug nanocarrier. 76 Mohsen et al developed optimized LNCs with small particle size, narrow size distribution, high drug payload and stability, as well as a sustained drug release profile by using the solvent-free phase inversion technique.…”
Section: Lipid-based Npsmentioning
confidence: 99%