Preparation and Ex-Vivo Evaluation of Stabilized Cefdinir Nanosuspension

Mahmood, Asia Abed Al-; Alhammid, Shaimaa N. Abd

doi:10.53350/pjmhs20221612789

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Upon dropping, the precipitation of nanoparticles occurs promptly, producing nanosuspension. The remaining organic solvent was evaporated by using a magnetic stirrer 1 hrour at 30 °C (Alwan and Rajab 2021;Al-Mahmood and Abd Alhammid 2022). The composition of (OLZ) nanoparticles is listed in Table 1.…”

Section: Formulation Of Olz Nanoparticlesmentioning

confidence: 99%

Formulation, in vitro and in vivo evaluation of olanzapine nanoparticles dissolving microneedles for transdermal delivery

Al-Shaibani,

Ghareeb

2024

PHAR

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Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for the treatment of schizophrenia. Its oral bioavailability is 60% due to its low solubility and pre-systemic metabolism. Hence, the present work aims to formulate and evaluate OLZ nanoparticles dissolving microneedles (MNs) for transdermal delivery to overcome the problems associated with drug administration orally. OLZ nanoparticles were prepared by the nanoprecipitation method. The optimized OLZ nanoparticle formula was utilized for the fabrication of dissolving MNs by loading OLZ nanodispersion into polydimethylsiloxane (PDMS) micromould cavities, followed by casting the polymeric solution of polyvinylpyrrolidone(PVP-K30) and polyvinyl alcohol (PVA) to form MN matrix. The results revealed that the optimized OLZ nanoparticle formula (NP-5) exhibited particle size 115.76±5.45 nm, entrapment efficiency 78.4±5.46, and zeta potential -19.01±1.6 mV. The results of MNs revealed that MN-4 exhibits a high drug content of 98.52%, and ex vivo permeation through rabbit skin exhibited that MN-4 permeates more effectively than a simple patch by approximately 5.16 fold. In vivo pharmacokinetics study revealed that the area under curve AUC 0-∞ of MN-4 was 6054.56±376 ng. h/ml as compared with AUC0-∞ of marketed OLZ tablet was 3975.77±373 ng. h/ml. It can be concluded that the dissolving MN-4 patch is considered a promising formula to overcome the problems associated with drug administration orally and could improve drug bioavailability, in addition to the ease of administering the medication to schizophrenic patients.

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Section: Formulation Of Olz Nanoparticlesmentioning

confidence: 99%

Formulation, in vitro and in vivo evaluation of olanzapine nanoparticles dissolving microneedles for transdermal delivery

Al-Shaibani,

Ghareeb

2024

PHAR

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Nanosuspensions in ophthalmology: Overcoming challenges and enhancing drug delivery for eye diseases

Fathi-Karkan,

Amiri Ramsheh,

Arkaban

et al. 2024

International Journal of Pharmaceutics

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Evaluation of types and concentration of bile salts impact on physical properties of nisoldipine-loaded bilosomes

Naji,

Al Gawhari

2024

PHAR

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Background: Bilosomes are lipid vesicles that exhibit flexibility and deformability. They consist of phospholipids and amphiphilic bile salts. Compared to the normal vesicular systems such as liposomes and niosomes, bilosomes provide several notable advantages, including simplified manufacturing, cost-effectiveness, and enhanced stability. Aim: The main objective of the present work was to evaluate the effect of different bile salts on the physical properties that include entrapment efficiency, vesicle size, and polydispersity index(PDI). In addition, in vitro drug release for nisoldipine (NSD) loaded bilosomes was evaluated. Methods: Nisoldipine-loaded bilosomes were made using a thin film hydration technique. Cholesterol along with surfactant (span 60) was employed, and the formulation also contained several different bile salts, including sodium deoxycholate (SDC), sodium glycocholate (SGC), and sodium taurocholate (STC). Results: The developed NSD bilosomes exhibited an entrapment efficiency ranging from 44.2 ± 0.3 to 82.36 ± 0.80% and a vesicle size diameter in the nanometric dimensions (166 ± 1.83 to 237.8 ± 3.3 nm). An in-vitro release study revealed that formulas prepared with SDC bile salts showed higher drug release than SGC and STC formulas. Increasing the bile salt amount from 5 mg to 10 mg increases entrapment efficiency with increasing vesicle size. Further increase in bile salt led to decreased entrapment efficiency with increased vesicle size. SDC gives the best result in terms of entrapment efficiency and acceptable size. STC provides the largest particle size due to its high molecular weight compared to SGC and SDC. Conclusion: The SDC bile salt component is better suited for manufacturing NSD bilosomes. This is because this component yields the best results regarding high entrapment efficiency, nano size, and prolonged drug release.

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Preparation and Ex-Vivo Evaluation of Stabilized Cefdinir Nanosuspension

Cited by 3 publications

References 24 publications

Formulation, in vitro and in vivo evaluation of olanzapine nanoparticles dissolving microneedles for transdermal delivery

Formulation, in vitro and in vivo evaluation of olanzapine nanoparticles dissolving microneedles for transdermal delivery

Nanosuspensions in ophthalmology: Overcoming challenges and enhancing drug delivery for eye diseases

Evaluation of types and concentration of bile salts impact on physical properties of nisoldipine-loaded bilosomes

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