Preparation and functionalization of boron nitride containing carbon nanohorns for boron neutron capture therapy

Iizumi, Yoko; Okazaki, Toshiya; Zhang, Minfang; Yuge, Ryota; Ichihashi, Toshinari; Nakamura, Minoru; Ikehara, Yuzuru; Iijima, Sumio; Yudasaka, Masako

doi:10.1016/j.carbon.2015.05.085

Cited by 7 publications

(8 citation statements)

References 40 publications

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“…49 Additional potential applications of BNNPs include their utilization for boron neutron capture therapy, 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 where BNNPs could promote high boron concentration, 50,51 or as bionanotransducers for cell sensing and stimulation due to their specific piezoelectric properties. 52-54…”

Section: Discussionmentioning

confidence: 99%

“…BNNTs were functionalized by folat groups, resulting in a significant increase in their uptake by cells . Additional potential applications of BNNPs include their utilization for boron neutron capture therapy, where BNNPs could promote a high boron concentration, , or as bionanotransducers for cell sensing and stimulation because of their specific piezoelectric properties. − …”

Section: Discussionmentioning

confidence: 99%

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Boron Nitride Nanoparticles with a Petal-Like Surface as Anticancer Drug-Delivery Systems

Сухорукова

Zhitnyak

Kovalskii

et al. 2015

ACS Appl. Mater. Interfaces

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Nanoparticles (NPs) have a great potential as nanosized drug-delivery carriers. Such systems must safely deliver the drug to the site of the tumor without drug leakage, effectively penetrate inside cancer cells, and provide intracellular drug release. Herein we developed an original and simple method aimed at the fabrication of spherical boron nitride NPs (BNNPs), 100-200 nm in diameter, with peculiar petal-like surfaces via chemical vapor deposition. Such structures were found to be able to absorb a large amount of antitumor drug-killing tumor cells. They revealed low cytotoxicity and rapid cellular uptake. BNNPs were saturated with doxorubicin (DOX) and then dispersed. The BNNPs loaded with DOX (BNNPs-DOX) were stable at neutral pH but effectively released DOX at pH 4.5-5.5. MTT assay and cell growth testing showed that the BNNPs-DOX nanocarriers had been toxic for IAR-6-1 cells. BNNPs loaded with DOX penetrated into the neoplastic IAR-6-1 cells using endocytic pathways, and then DOX released into the cytoplasm and cell nuclei and resulted in cell death.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Boron Nitride Nanoparticles with a Petal-Like Surface as Anticancer Drug-Delivery Systems

Сухорукова

Zhitnyak

Kovalskii

et al. 2015

ACS Appl. Mater. Interfaces

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“…SWCNHs that possess similar structures as those of CNTs also allow the multifunctionalization of target ligands and drug molecules on both the inner and outer tube walls. − After oxidation, the hole of the SWCNHs can be opened and filled with functional carboxyl groups at the edges that provide covalent binding sites for different drug molecules. The intrinsic cytotoxicity of SWCNHs is found to be lower than that of the CNTs due to the less-contaminated production reaction in the absence of metal catalysts.…”

Section: Nanocarbons For In Vitro Applications: Sensing Imaging and D...mentioning

confidence: 99%

Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery

et al. 2019

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Nanocarbons with different dimensions (e.g., 0D fullerenes and carbon nanodots, 1D carbon nanotubes and graphene nanoribbons, 2D graphene and graphene oxides, and 3D nanodiamonds) have attracted enormous interest for applications ranging from electronics, optoelectronics, and photovoltaics to sensing, bioimaging, and therapeutics due to their unique physical and chemical properties. Among them, nanocarbon-based theranostics (i.e., therapeutics and diagnostics) is one of the most intensively studied applications, as these nanocarbon materials serve as excellent biosensors, versatile drug/gene carriers for specific targeting in vivo, effective photothermal nanoagents for cancer therapy, and promising fluorescent nanolabels for cell and tissue imaging. This review provides a systematic overview of the latest theranostic applications of nanocarbon materials with a comprehensive comparison of the characteristics of different nanocarbon materials and their influences on theranostic applications. We first introduce the different carbon allotropes that can be used for theranostic applications with their respective preparation and surface functionalization approaches as well as their physical and chemical properties. Theranostic applications are described separately for both in vitro and in vivo systems by highlighting the protocols and the studied biosystems, followed by the toxicity and biodegradability implications. Finally, this review outlines the design considerations for nanocarbon materials as the key unifying themes that will serve as a foundational first principle for researchers to study, investigate, and generate effective, biocompatible, and nontoxic nanocarbon materials-based models for cancer theranostics applications. Finally, we summarize the review with an outlook on the challenges and novel theranostic protocols using nanocarbon materials for hard-to-treat cancers and other diseases. This review intends to present a comprehensive guideline for researchers in nanotechnology and biomedicine on the selection strategy of nanocarbon materials according to their specific requirements. CONTENTSRelated Molecules by Different Nano-54 carbon Materials W 55 2.2. Nanocarbons for in Vitro Bioimaging AD 56 2.2.1. In Vitro Imaging by Graphene AD 57 2.2.2. In Vitro Imaging by Carbon Nanotubes AF 58 2.2.3. In Vitro Imaging by Fullerenes AH 59 2.2.4. In Vitro Imaging by Carbon Nanohorns AI 60 2.2.5. In Vitro Imaging by Nanodiamonds AJ

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“…Such an effect results from the presence of leaky vasculature and deficient lymphatic drainage in the vicinity of tumors, which ultimately results in the passive accumulation of nontargeted nanosized materials in the tumor tissue after intravenous administration. A plethora of nanostructured materials that rely on the EPR effect have been proposed as boron delivery agents, including liposomes, − carbon nanotubes, boron nitride nanotubes, − magnetic nanoparticles, , boron carbide nanoparticles, , borosilicates, gold nanoparticles, , and carbon dots . Noteworthily, the EPR effect is a highly heterogeneous phenomenon, which varies substantially among different tumor types, patients, and even regions within a single tumor. , As a consequence, the extravasation of boron-rich nanomedicines may follow a heterogeneous pattern and lead to suboptimal treatment efficacy due to the short range of recoil ions generated upon neutron irradiation.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Evaluation of Multifunctional Gold Nanorods for Boron Neutron Capture and Photothermal Therapies

Pulagam

Henriksen‐Lacey

Uribe

et al. 2021

ACS Appl. Mater. Interfaces

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The incidence and mortality of cancer demand more innovative approaches and combination therapies to increase treatment efficacy and decrease off-target side effects. We describe a boron-rich nanoparticle composite with potential applications in both boron neutron capture therapy (BNCT) and photothermal therapy (PTT). Our strategy is based on gold nanorods (AuNRs) stabilized with polyethylene glycol and functionalized with the water-soluble complex cobalt bis(dicarbollide) ([3,3′-Co(1,2-C2B9H11)2]−), commonly known as COSAN. Radiolabeling with the positron emitter copper-64 (64Cu) enabled in vivo tracking using positron emission tomography imaging. 64Cu-labeled multifunctionalized AuNRs proved to be radiochemically stable and capable of being accumulated in the tumor after intravenous administration in a mouse xenograft model of gastrointestinal cancer. The resulting multifunctional AuNRs showed high biocompatibility and the capacity to induce local heating under external stimulation and trigger cell death in heterogeneous cancer spheroids as well as the capacity to decrease cell viability under neutron irradiation in cancer cells. These results position our nanoconjugates as suitable candidates for combined BNCT/PTT therapies.

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Preparation and functionalization of boron nitride containing carbon nanohorns for boron neutron capture therapy

Cited by 7 publications

References 40 publications

Boron Nitride Nanoparticles with a Petal-Like Surface as Anticancer Drug-Delivery Systems

Boron Nitride Nanoparticles with a Petal-Like Surface as Anticancer Drug-Delivery Systems

Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery

In Vivo Evaluation of Multifunctional Gold Nanorods for Boron Neutron Capture and Photothermal Therapies

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