Preparation and<i>in vitro</i>characterization of piroxicam enteric coated pellets using powder layering technique

Varshosaz, Jaleh; Tavakoli, Naser; Serri, Azadeh

doi:10.1080/10837450802626288

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…The material have been used and experimented as viscolizing agent i.e. thickening agent (2,3), in controlled release systems (4) and as a coating polymer (5), as a bioadhesive (6), in solid dispersion to enhance drug solubility (7) and as a binder (8). In the USP30-NF25 (9), the excipient is listed under coating agent, suspending and/or viscosity-increasing agent and tablet binder.…”

Section: Introductionmentioning

confidence: 99%

HPMC Capsules: Current Status and Future Prospects

Al-Tabakha

2010

J Pharm Pharm Sci

111

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Hydroxypropyl methylcellulose (HPMC) is employed for a wide variety of pharmaceutical and food preparations. Its applications as viscolizing agent (thickening agent), coating polymer, bioadhesive, in solid dispersion to enhance solubility, binder in the process of granulation and in modified release formulations have been well documented. One other notable use is in the production of capsule shells, replacing the animal derived gelatin in conventional two-piece capsules. The aim of this review is to systemically survey published literature on the HPMC use in capsule shells and resolve questions regarding their suitability as a replacement for hard gelatin capsules. Future refinements in the production and filling of HPMC capsule shells and improvement in their in vivo/in vitro dissolution would ensure their superiority over hard gelatin capsules.

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Section: Introductionmentioning

confidence: 99%

HPMC Capsules: Current Status and Future Prospects

Al-Tabakha

2010

J Pharm Pharm Sci

111

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“…Then, the mixture was coated on the inert core pellets by powder-layering technique and using a conventional coating pan model DKE/DKS (Erweka, Heusenstamm, Germany). The binding solution (PVP 0.5%) and the drug-excipient mixture were sprayed consecutively onto the null pellets at a constant rate to increase the size of pellets [ 20 – 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…In the pelletization techniques, the fine powders are aggregated to form larger, spherical particles called pellets [20]. Pellets have an enormous surface area in contrast to tablets and capsules, which increases their exposure and interaction with the surrounding medium, thereby increasing the dissolution rate of the drug [21][22][23][24]. Deferasirox (DFX) is an iron chelator drug that helps to remove excess iron in the body, and it is usually administered in the treatment of beta-thalassemia and sickle cell disorders [25].…”

Section: Introductionmentioning

confidence: 99%

Solid Dispersion Pellets: An Efficient Pharmaceutical Approach to Enrich the Solubility and Dissolution Rate of Deferasirox

Farmoudeh

Rezaeiroshan

Abbaspour

et al. 2020

BioMed Research International

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Deferasirox (DFX) is an oral iron-chelating agent and classified into class II of the Biopharmaceutics Classification System. Low bioavailability of the drug due to insufficient solubility in physiological fluids is the main drawback of DFX. The idea of the current study was to explore the potential of solid dispersion (SD) as an effective method to improve the dissolution rate of DFX in pellets. The SDs were made by the solvent evaporation technique using polyethylene glycol 4000 (PEG 4000) and polyvinylpyrrolidone K25 with different drug-to-carrier ratios. Then, the dispersion was milled and mixed with other components and the mixture layered on sugar-based cores by pan coating technique. The pellets were evaluated in terms of size distribution, morphology (SEM), and dissolution behaviour. Drug-polymer interactions were studied using differential scanning calorimetry (DSC), X-ray diffraction study (XRD), and Fourier transformation infrared (FTIR) spectroscopy. The pellets coated with SD showed a remarkable rise in the solubility of DFX than that of free drug-loaded pellets. The dispersion with PVP K25 showed a faster dissolution rate as compared to other mixtures. The DSC and XRD analysis indicated that the drug was in the amorphous state when dispersed in the polymer. The FTIR studies demonstrated any ruled out interaction between drug and polymer. The SEM showed smoothness on the surface of the pellets. It is resolved that the SD method considerably enriched the dissolution rate of DFX in pellets, which can also be utilized for other poorly water-soluble drugs.

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“…Considering the GI side effects of ketoprofen, it is desirable to develop an enteric preparation to reduce its release in the stomach. Due to increased solubility and immediate absorption in higher pH (intestine), it is advised to control release in order to obtain prolonged effects as with other NSAIDs (Yang et al, 2008;Varshosaz et al, 2009). In the present study, shellac was used as an enteric polymer to prevent/reduce drug release in the stomach along with ethyl cellulose (Ethocel ® 45 premium grade) to extend the release in the intestinal region.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluations of ketoprofen extended release pellets prepared using powder layering technique in a rotary centrifugal granulator

et al. 2011

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In the present study, an extended release pellet dosage form of ketoprofen was prepared using powder layering technique. A combination of ethyl cellulose (45 cps) and shellac polymers was used as a binder (12% w/w polymer) during drug layering and an extended release coating (1:3 ratio at 2%, 4% and 7% w/w polymer) within the same apparatus. The coated pellets were characterized for sphericity, Hardness-Friability Index, and drug content, and also underwent scanning electron microscopy. In vitro dissolution was performed in 900 mL of phosphate buffer (pH 6.8) using paddle apparatus at 100 rpm. Ethyl cellulose and shellac when used as binders during drug loading did not extend ketoprofen release beyond 3 h. However, coating of the drug loaded pellets using ethyl cellulose and shellac resulted in an extended release profile of about 10 h. Using Higuchi's model and the Korsmeyer equation, the drug release mechanism from the pellets was found to be an anomalous type involving diffusion and erosion. Scanning electron microscopy was used to visualize the pellet morphology and drug release mechanism during dissolution testing. In vivo evaluations of the extended release pellets in rats indicated a significant increase in the time to reach maximum concentration (t(max)) and extent of absorption (AUC(0-∞)) compared to the ketoprofen immediate release tablet blend dispersed and dosed. In conclusion, extended release pellets of ketoprofen could perform therapeutically better than conventional dosage forms, leading to improved efficacy for a prolonged period.

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Preparation andin vitrocharacterization of piroxicam enteric coated pellets using powder layering technique

Cited by 8 publications

References 19 publications

HPMC Capsules: Current Status and Future Prospects

HPMC Capsules: Current Status and Future Prospects

Solid Dispersion Pellets: An Efficient Pharmaceutical Approach to Enrich the Solubility and Dissolution Rate of Deferasirox

In vitro and in vivo evaluations of ketoprofen extended release pellets prepared using powder layering technique in a rotary centrifugal granulator

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