Preparation and in vitro characterization studies of astaxanthin-loaded nanostructured lipid carriers with antioxidant properties

Gu, Liyuan; Wang, Wen‐Juan; Wu, Bi; Ji, Suping; Xia, Qiang

doi:10.1177/08853282231189779

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…The data showed that the amount of drug released by the AST group was 60.1 ± 1.73% at 2 h and 70.3 ± 2.36% at 8 h. For AST@PLGA, the highest release rate was observed within 1 h, which accounted for 37.2 ± 3.82% of the total. This could be due to the loss of weakly adsorbed AST molecules on or near the surface of AST@PLGA (25). The release rate of AST@PLGA progressively slowed between 1 and 4 h; However, drug release persisted.…”

Section: The Drug Loading Of Ast@plga and In Viro Release Studymentioning

confidence: 99%

Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles ameliorate ulcerative colitis through antioxidant effects

Li,

Zhou,

Yuan

et al. 2023

Front. Nutr.

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IntroductionAstaxanthin (AST) is a type of carotenoid with strong antioxidant effects. However, the development and use of AST are limited by its water insolubility and low bioavailability. This study aims to investigate whether AST@PLGA can inhibit UC and reveal its possible mechanism.MethodsWe tested the particle size, polydispersity index, and zeta potential of AST@PLGA. Then, the in vitro release and antioxidant capacity of AST@PLGA were tested. Finally, the mouse model of colitis was established and SOD, MDA, TNF-α, IL-1β, IL-6 and P38 as well as ERK were detected from mice.ResultsParticle size, polydispersity index and zeta potential of AST @PLGA were 66.78 ± 0.64 nm, 0.247 and -9.8 ± 0.53 mV, respectively, and were stable within 14 days. Then, it was observed that the AST@PLGA nanoparticles not only maintained the effect of AST but also had a sustained release effect. Experiments in mice showed that AST@PLGA effectively reduced MDA, TNF-α, IL-1β and IL-6 levels and increased SOD levels. AST@PLGA also downregulated the protein expression of P38 and ERK. The results showed the positive protective effect of AST@PLGA in inhibiting acute colitis.DiscussionAST@PLGA nanoparticles have good stability and alleviating effect in colitis, which could be functional foods in the future.

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Section: The Drug Loading Of Ast@plga and In Viro Release Studymentioning

confidence: 99%

Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles ameliorate ulcerative colitis through antioxidant effects

Li,

Zhou,

Yuan

et al. 2023

Front. Nutr.

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“…The ketocarotenoid astaxanthin (3,3 ′ -dihydroxyβ, β'-carotene-4,4 ′ -dione) is a red pigment with antioxidant activity as a result of its hydroxyl and keto groups [2]. Astaxanthin is used as a raw material for pharmaceuticals and functional foods because it suppresses inflammation, is nontoxic, and prevents diabetes and cancer [2,3]. By 2027, the market value of astaxanthin is expected to increase to USD 3.4 billion [4].…”

Section: Introductionmentioning

confidence: 99%

Effects of Four Organic Carbon Sources on the Growth and Astaxanthin Accumulation of Haematococcus lacustris

Byeon,

An,

Kim

et al. 2023

Life

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The microalga Haematococcus lacustris has a complex life cycle and a slow growth rate, hampering its mass cultivation. Culture of microalgae with organic carbon sources can increase the growth rate. Few studies have evaluated the effects of organic carbon sources on H. lacustris. We compared the vegetative and inductive stages of H. lacustris under autotrophic and mixotrophic conditions using four organic carbon sources: sodium acetate, glycerol, sodium gluconate, and ribose, each at various concentrations (0.325, 0.65, 1.3, and 2.6 g/L). The cell density was increased by 1.3 g/L of glycerol in the vegetative stage. The rapid transition to the inductive stage under nitrogen-depletion conditions caused by 1.3 or 2.6 g/L sodium acetate promoted the accumulation of astaxanthin. The production of astaxanthin by H. lacustris in mass culture using organic carbon sources could increase profitability.

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The effect of physical stability and modified gastrointestinal tract behaviour of resveratrol-loaded NLCs encapsulated alginate beads

Manikandan,

Jose,

Karuppaiah

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Nanostructured lipid carriers (NLC) have low storage and gastrointestinal stability, limiting their applicability. The work aimed to elevate the stability and behaviour of NLC in the alimentary tract by creating an Alginate bead. Through the extrusion dropping procedure, Resveratrol (RES) loaded NLC were e ciently integrated into alginate beads. The incorporation had no signi cant impact on the particle size, morphology, or inner structure of NLC, as assessed using DLS (Dynamic Light Scattering), SEM (Scanning Electron Microscopy), Differential Scanning Calorimetry (DSC) and FT-IR (Fourier Transform Infra-Red). Incorporating NLC into alginate beads improves its physical stability compared to Dispersion of NLC as well as NLC-Sol. An in vitro release investigation found that the NLC-alginate beads released RES more slowly than optimized NLC formulation (RES-NLCs-opt) and NLC-alginate sol. Research on simulated in vitro digestive models revealed that just a small amount of integrated NLC may permeate stomach uid due to its tiny size. The slow diffusion of NLC from alginate to intestinal uid prevented aggregation and allowed for gentle hydrolysis of the lipid matrix. Incorporating NLC in alginate beads shows promise for improving stability, modifying gastrointestinal behaviour, and controlling release throughout the process of digestion.

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Preparation and in vitro characterization studies of astaxanthin-loaded nanostructured lipid carriers with antioxidant properties

Cited by 6 publications

References 40 publications

Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles ameliorate ulcerative colitis through antioxidant effects

Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles ameliorate ulcerative colitis through antioxidant effects

Effects of Four Organic Carbon Sources on the Growth and Astaxanthin Accumulation of Haematococcus lacustris

The effect of physical stability and modified gastrointestinal tract behaviour of resveratrol-loaded NLCs encapsulated alginate beads

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