Preparation and in vitro evaluation of plasma-sprayed Mg2SiO4 coating on titanium alloy

Xie, Yi; Zhai, Wentao; Chen, Lei; Chang, Jiang; Zheng, Xuebin; Ding, Chuanxian

doi:10.1016/j.actbio.2009.03.003

Cited by 41 publications

(37 citation statements)

References 39 publications

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“…Similarly, coating the surface layer has been shown to enhance the osteoconductive properties of the metal (e.g. strontium-incorporated Ti oxide, magnesium, calcium phosphate), improving graft integration within the host tissue [24][25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Investigating the biological response of human mesenchymal stem cells to titanium surfaces

German¹,

Osei-Bempong²,

Knuth³

et al. 2014

Journal of Orthopaedic Surgery and Research

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Section: Discussionmentioning

confidence: 99%

Investigating the biological response of human mesenchymal stem cells to titanium surfaces

German¹,

Osei-Bempong²,

Knuth³

et al. 2014

Journal of Orthopaedic Surgery and Research

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“…Previous studies demonstrated similar results where cells on Mg containing surfaces showed higher proliferation and differentiation compared to Mg-free specimens. 30,38,39 Furthermore, Mg ions are considered to be beneficial for bone cell attachment. Zreiqat et al 23 reported that cells grown on Mg-modified alumina exhibited a significantly increased adhesion since binding of integrins to specific ligands depends on the presence of divalent cations.…”

Section: Discussionmentioning

confidence: 99%

“…30 In this study, the coating adhesion was investigated by a scratch test and via insertion experiments with coated zirconia screw implants. Figure 4 shows representative top views of the sample surface before (a) to (c) and after (d) to (e) scratch test carried out with a sharpened bovine femur, where the dashed black lines correspond to the scratch path.…”

Section: Mechanical Stability and Coating Adhesionmentioning

confidence: 99%

Magnesium-containing mixed coatings on zirconia for dental implants: mechanical characterization and in vitro behavior

et al. 2015

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An important challenge in the field of dental and orthopedic implantology is the preparation of implant coatings with bioactive functions that feature a high mechanical stability and at the same time mimic structural and compositional properties of native bone for a better bone ingrowth. This study investigates the influence of magnesium addition to zirconia-calcium phosphate coatings. The mixed coatings were prepared with varying additions of either magnesium oxide or magnesium fluoride to yttria-stabilized zirconia and hydroxyapatite. The coatings were deposited on zirconia discs and screw implants by wet powder spraying. Microstructure studies confirm a porous coating with similar roughness and firm adhesion not hampered by the coating composition. The coating morphology, mechanical flexural strength and calcium dissolution showed a magnesium content-dependent effect. Moreover, the in vitro results obtained with human osteoblasts reveal an improved biological performance caused by the presence of Mg 2þ ions. The magnesiumcontaining coatings exhibited better cell proliferation and differentiation in comparison to pure zirconia-calcium phosphate coatings. In conclusion, these results demonstrate that magnesium addition increases the bioactivity potential of zirconia-calcium phosphate coatings and is thus a highly suitable candidate for bone implant coatings.

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“…β-TCP, M 2 S and MS ceramic discs with dimensions of 8 mm×0.8 mm were prepared as described previously [8,11,12]. The ceramic discs were sonicated for 5 min, rinsed with distilled water and radiosterilized.…”

Section: Preparation Of Ceramic Discs and Cell Seedingmentioning

confidence: 99%

“…Ni et al [10] and Xie et al [11] reported a new magnesium-silicate ceramic, forsterite (Mg 2 SiO4, M 2 S), then demonstrated its good biocompatibility and mechanical properties. Our previous work reported another new magnesium-silicate ceramic, clinoenstatite (MgSiO 3 , MS), and revealed that the ionic products of the MS powder extracts can promote the proliferation of mouse fibroblasts (L929 cell); and the murine embryonic mesenchymal stem cells adhered well; higher proliferation capacities on the clinoenstatite ceramics were also observed than that on the traditional hydroxyapatite ceramics [12].…”

mentioning

confidence: 99%

A comparative study of proliferation and osteogenic differentiation of rat adipose-derived stem cells in β-tricalcium phosphate (β-TCP), forsterite (Mg2SiO4) and clinoenstatite (MgSiO3)

et al. 2013

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In this study, the effects of forsterite and clinoenstatite powder extracts on the proliferation and osteogenic differentiation of rat adipose-derived stem cells (ASCs) were investigated and compared with the β-tricalcium phosphate (β-TCP) powder extracts. Methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and live-dead staining were performed to evaluate the viability and proliferation of rat ASCs. Osteogenic differentiation of rat ASCs were assayed by alkaline phosphatase (ALP) staining and ALP activity test. The expression of osteogenic marker genes (alkaline phosphatase (ALP), runt related transcription factor 2 (Runx2), collagen type Iα1 (Col1α1), secreted phosphoprotein1 (Spp1, osteopontin), integrin binding sialoprotein (Ibsp), bone gla protein (Bglap)) were detected by real-time polymerase chain reaction (PCR). The MTT assay and the live-dead staining showed that all the three ceramics possessed good cytocompatibility with rat ASCs. Furthermore, forsterite and clinoenstatite promoted the proliferation of rat ASCs compared with β-TCP. The results of the ALP activity test and the real-time PCR demonstrated that forsterite and clinoenstatite promoted the osteogenic differentiation of rat ASCs. These results suggested that forsterite and clinoenstatite are bioactive ceramics that may be used for preparation of bone tissue engineering (BTE) scaffolds.

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Preparation and in vitro evaluation of plasma-sprayed Mg2SiO4 coating on titanium alloy

Cited by 41 publications

References 39 publications

Investigating the biological response of human mesenchymal stem cells to titanium surfaces

Investigating the biological response of human mesenchymal stem cells to titanium surfaces

Magnesium-containing mixed coatings on zirconia for dental implants: mechanical characterization and in vitro behavior

A comparative study of proliferation and osteogenic differentiation of rat adipose-derived stem cells in β-tricalcium phosphate (β-TCP), forsterite (Mg2SiO4) and clinoenstatite (MgSiO3)

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