Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen for colon targeting

Narala, Sagar; Nyavanandi, Dinesh; Mandati, Preethi; Youssef, Ahmed Adel Ali; Alzahrani, Abdullah; Kolimi, Praveen; Zhang, Feng; Repka, Michael A.

doi:10.1016/j.ijpx.2022.100156

Cited by 8 publications

(6 citation statements)

References 32 publications

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“…Cool it down afterward to acquire a solid mass; further reduce this by crushing and sieving out any larger particles -like albendazole or urea. Perfectly homogenous results each time [67][68][69][70][71][72][73] .…”

Section: F) Co-precipitation Methodmentioning

confidence: 99%

Contemporary Review on Solubility Enhancement Techniques

NARMADA¹

2023

J. Drug Delivery Ther.

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The limited water solubility of pharmacoactive molecules hinders their ability to be used as pharmacological agents, yet the indispensability of a certain solubility parameter precludes any compromises. To overcome this challenge, various methods are employed in order to increase their bioavailability. Pharmaceutical molecules with lower solubility present an elevated risk of failure for drug development and innovation. Their solubility affects important processes such as pharmacokinetics, pharmacodynamics, distribution, protein binding, and absorption. As a result these parameters are greatly impacted by the dissolution rate of a particular molecule. Out of all pharmaceutical dosage forms, more than half are oral. For the drug molecule to reach its target site and be effective therapeutically, solubility and bioavailability must be taken into consideration. Unfortunately, during screening programs conducted by the pharmaceutical industry it became evident that nearly 40% of new chemical entities (NCEs) face various roadblocks when transitioning from formulation to development due to their poor solubility and bioavailability. The pharmaceutical industry is constantly confronted with the difficulty of improving drug bioavailability and solubility in formulations. This article covers a range of technological advancements to boost the solubility of insoluble drugs, such as complexation, emulsions and micelles production, microemulsion generation with cosolvents, polymeric micelle preparation methods, particle size decrease techniques, pharmaceutical salts application, prodrugs usage, solid-state alteration practices, soft gel technology implementation crystal engineering approaches and nanomorphology. Through this review, we will discuss a variety of more complex methods for improving solubility and bioavailability such as crystal engineering, micronization, solid dispersions, nano sizing, and use of cyclodextrins, solid lipid nanoparticles (SLNPs), colloidal drug delivery systems and drug conjugates. We'll also provide references to studies that have been conducted in connection with these topics. Keywords: Solubility, permeability, bioavailability, nano particles drug delivery systems, microemulsions, low water solubility

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Section: F) Co-precipitation Methodmentioning

confidence: 99%

Contemporary Review on Solubility Enhancement Techniques

NARMADA¹

2023

J. Drug Delivery Ther.

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“…One key area of exploration is the development of novel lipid materials that can further improve stability, control drug release, and enhance targeting [58]. Advances in nanotechnology could facilitate the creation of multifunctional lipid nanoparticles, where different therapeutic agents are encapsulated within a single nanoparticle, enabling combination therapy [59][60][61][62]. Furthermore, the application of machine learning and artificial intelligence in the design of lipid nanoparticles could revolutionize the field [63].…”

Section: Future Directionmentioning

confidence: 99%

Lipid-based nanoparticles and their recent advances

Onteru Sujeevan

2024

GSC Adv. Res. Rev.

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Lipid-based nanoparticles hold great potential for drug delivery, providing biocompatibility and the ability to encapsulate both hydrophilic and hydrophobic drugs. However, there are certain challenges associated with small molecules, such as leakage and premature release, which can compromise their effectiveness. Despite these challenges, lipid nanoparticles offer advantages in terms of solubility, stability, and targeted delivery, thereby reducing side effects. Additionally, they can be customized for specific molecules, ensuring biocompatibility and biodegradability. While complications may arise, lipid nanoparticles offer numerous benefits for loading biomolecules, improving pharmacokinetics, and enhancing therapeutic effects. It is important to address stability and loading challenges when encapsulating biomolecules and consider potential immunogenic responses that may impact biocompatibility and safety.

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“…Slugging and compressing the powder utilizing pressure rolls are two frequently used techniques for dry granulation; the latter is frequently carried out using a device like the chilosonator. 50…”

Section: Dry Granulationmentioning

confidence: 99%

“…The accumulated particles have been filtered or crushed to generate granules, much like slugs. 50 The chilsonator has a variety of uses, including the granulation of inorganic materials, compaction of the excipients, and natural products to develop immediate as well as sustained release formulations.…”

Section: Rollar Compactionmentioning

confidence: 99%

A Bird Eye View on Effervescent Drug Delivery System

Jadhav,

Gangurde

2023

IJDDT

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Effervescent drug delivery systems (EDDS) have gained significant attention in the pharmaceutical industry due to their unique characteristics and potential advantages over conventional dosage forms. This comprehensive review aims to provide an in-depth understanding of EDDS, including their formulation strategies, underlying mechanisms, and diverse applications in drug delivery. EDDS are effervescent dosage forms that release drugs upon water dissolution, leading toward carbon dioxide gas generation. The effervescence, resulting from the reaction between an acid and a base, facilitates rapid drug dissolution and enhances drug bioavailability. The primary components of an EDDS include an active pharmaceutical ingredient (API), effervescent agents (e.g., organic acids and bases), binders, disintegrants, and other excipients. Effervescent tablets, granules, powders, and effervescent-coated dosage forms are commonly employed formulations. Several factors, such as pH, temperature, solubility, and particle size, influence the drug’s effervescence process and subsequent release kinetics. The drug release mechanisms from EDDS can be attributed to various phenomena, including effervescence-driven disintegration, gas evolution, and solubilization. The effervescence-induced carbon dioxide bubbles mechanically disrupt the dosage form, leading to enhanced drug dissolution and subsequent release. Additionally, the carbon dioxide gas acts as a propellant, providing rapid drug delivery and potentially improving patient compliance. EDDS find applications in diverse therapeutic areas, including analgesics, antacids, dietary supplements, and antiviral agents. They offer several advantages, such as improved drug stability, enhanced bioavailability, increased patient convenience, and ease of administration, particularly for populations with swallowing difficulties. Furthermore, EDDS can be tailored to achieve controlled release, targeted drug delivery, and taste masking through appropriate formulation modifications. However, challenges associated with EDDS include their sensitivity to environmental conditions, potential drug degradation during effervescence, and the need for specialized packaging to maintain stability. The selection of suitable effervescent agents, excipients, and manufacturing processes is crucial to overcome these limitations and ensure consistent product performance. In conclusion, effervescent drug delivery

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Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen for colon targeting

Cited by 8 publications

References 32 publications

Contemporary Review on Solubility Enhancement Techniques

Contemporary Review on Solubility Enhancement Techniques

Lipid-based nanoparticles and their recent advances

A Bird Eye View on Effervescent Drug Delivery System

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