Preparation and investigation of acetyl salicylic acid-caffeine complex for rectal administration

Fouad, Ehab A.; El-Badry, Mahmoud; Alanazi, Fars K.; Arafah, Maha; Al-Ashban, R.M.; Alsarra, Ibrahim A.

doi:10.3109/10837450903127350

Cited by 11 publications

(8 citation statements)

References 34 publications

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“…, where the asy and sy CH 3 peaks are at 2953 and 2915 cm −1 , respectively, strong asy(CH 2 ) and sy(CH 2 ) at 2870 and 2848 cm −1 , broad band OH extending from 3400 to 2400 cm −1 that partially obscures the CH stretching bands, CO stretching at 1229 cm −1 and adsorption of bending CH 2 (rocking), called a long chain bend is noticeable at 722 cm −1 . The most important peak of transformation of carboxylic acid to carboxylate is at 1548 cm −1 . As the lone pair electron in glutamine acts as a base, interaction between glutamine and palmitic acid would happen in the nitrogen atom in the glutamine.…”

Section: Resultsmentioning

confidence: 99%

The effects of glutamine palmitic acid content on properties of high density polyethylene/silica composites

Samsudin

Ismail

Othman

et al. 2016

Vinyl Additive Technology

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In this study, Glut Palmitate (GP) as the compatibilizer in silica filled high density polyethylene (HDPE) composites was synthesized from Glutamine and Palmitic acid. GP with varied content (0.5, 1, 2, and 3 phr) were then added in the composites to evaluate its effect on the mechanical properties, water absorption, chemical bonding, and surface morphology. The findings of this study showed that GP achieved its function as a compatibilizer by enhancing the adhesion between HDPE and silica through the formation of hydrogen bonding as investigated by Fourier transform infra-red as well as good interaction on interface morphology observed in scanning electron microscopy micrograph. The mechanical properties showed that the tensile strength, elongation at break, flexural strength, and impact properties of composites had optimum value at 1 phr and the modulus of the composite increased with the addition of GP. Meanwhile, the addition of 2 phr of GP in composites reduced water absorption by 33% in the composite compared to the control composites. J. VINYL ADDIT. TECHNOL., 00:000-000, 2016.

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Section: Resultsmentioning

confidence: 99%

The effects of glutamine palmitic acid content on properties of high density polyethylene/silica composites

Samsudin

Ismail

Othman

et al. 2016

Vinyl Additive Technology

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“…Cyclodextrins are torusshaped oligosaccharides obtained from the enzymatic degradation of starch by bacteria [10], and are known to form inclusion complexes with many lipophilic organic molecules both in solution and in the solid-state. Caffeine is a natural xanthine alkaloid compound that acts as a central nervous system stimulant which is reported to form complex by a charge transfer mechanism [11]. Various celecoxib complexes were formulated and their physiochemical properties were investigated.…”

Section: Introductionmentioning

confidence: 99%

Development of Celecoxib Complexes: Characterization and Cytotoxicity Studies in MCF-7

Alam¹

2013

Pharmaceut Anal Acta

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The objective of the study was to compare the complexing ability of Celecoxib with different complexing agents. Inclusion complex of Celecoxib is well established in literature but its evaluation in terms of thermodynamics was not studied elaborately. Hence after characterization of complexes with Differential scanning calorimeter, X-ray diffraction, NMR and % complexation efficiency, its solvation energetics and thermodynamics were determined. Complexation ability of celecoxib with caffeine was also evaluated, where non-inclusion (charge transfer) mechanism is involved. So, these two mechanisms of complexation were also tested with respect to each other. In this manuscript, new complexing agents (humic acid and fulvic acid) were also introduced for Celecoxib. These lie in the category of natural organic matter and we explored an indigenous source (Shilajit) to extract it. Other agents used for the development of complex were HP-β-CD and β-CD. Release mechanism of drug from complexes was studied by in vitro release studies. MTT assays were also performed to assess in vitro cell toxicity potential of the complexes in comparision to neat drug. Pha rm a c e u tic a An a ly t ic a A cta

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“…Cyclodextrins are torus-shaped oligosaccharides obtained from the enzymatic degradation of starch by bacteria (Szetjli, 1998) which readily form inclusion complexes with many lipophilic organic molecules both in solution and in the solid-state. Caffeine is a natural xanthine alkaloid compound that acts as a central nervous system stimulant and reportedly forms complexes by a charge transfer mechanism (Fouad et al, 2010). The study was aimed at identifying the best drug inclusion complex to be used in treatment of vaginal candidiasis.…”

Section: Introductionmentioning

confidence: 99%

In vitro/in vivo performance of different complexes of itraconazole used in the treatment of vaginal candidiasis

Mirza

Rahman

Talegaonkar

et al. 2012

Braz. J. Pharm. Sci.

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A large majority of new chemical entities and many existing drug molecules exhibit poor aqueous solubility, which may limit their potential use in developing drug formulations, with optimum bioavailability. One of the approaches to improve the solubility of a poorly water soluble drug and eventually its bioavailability is complexation with agents like humic acid (HA), fulvic acid (FA), β-cyclodextrin (β-CD), 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and caffeine (Caff). The current work emphasized at employing these agents to prepare different complexes and their in vitro/in vivo assessment. All the complexes evaluated for their complexation efficiency and authenticated by molecular modeling; conformational analysis, differential scanning calorimetry (DSC), X-ray diffraction (XRD), nuclear magnetic resonance (NMR) and mass spectroscopy. Furthermore, the complexes were assessed in an in vivo, rat vaginal model for their efficacy in treatment of vaginal candidiasis. Amongst the five tested complexes, fulvic acid-itraconazole complex yielded better solubility as well as in vivo efficacy and therefore may further be explored for developing a commercial formulation for treating vaginal candidiasis. A maioria das novas entidades químicas e muitas moléculas de fármacos existentes apresenta fraca solubilidade em água, o que pode limitar seu uso potencial no desenvolvimento de formulações com biodisponibilidade ideal. Uma das abordagens para melhorar a solubilidade de um fármaco pouco solúvel em água e, eventualmente, a sua biodisponibilidade é a complexação com agentes como o ácido húmico (HA), ácido fúlvico (FA), β-ciclodextrina (β-CD), 2-hidroxipropil-β-ciclodextrina (HP-β-CD) e cafeína (Caff). O presente trabalho baseia-se no uso desses agentes para preparar diferentes complexos e suas avaliações in vitro/in vivo. Todos os complexos foram avaliados quanto à eficiência de complexação por modelação molecular, análise conformacional, calorimetria de varredura diferencial (DSC), difração de raios-X (XRD), ressonância magnética nuclear (RMN) e espectroscopia de massas. Além disso, os complexos foram avaliados in vivo, em ratas, no tocante à sua eficácia no tratamento de candidíase vaginal. Entre os cinco complexos testados, o complexo de ácido fúlvico-itraconazol foi o que apresentou melhor solubilidade, bem como melhor eficácia in vivo e, portanto, pode ser explorado para o desenvolvimento de uma formulação comercial para o tratamento de candidíase vaginal. Uniterms

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Preparation and investigation of acetyl salicylic acid-caffeine complex for rectal administration

Cited by 11 publications

References 34 publications

The effects of glutamine palmitic acid content on properties of high density polyethylene/silica composites

The effects of glutamine palmitic acid content on properties of high density polyethylene/silica composites

Development of Celecoxib Complexes: Characterization and Cytotoxicity Studies in MCF-7

In vitro/in vivo performance of different complexes of itraconazole used in the treatment of vaginal candidiasis

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