Preparation and Investigation of Tabletted Medicinal Formulations of a Solid Dispersion of Rutin

Krasnyuk, I. I.; Ковальский, Иван Васильевич; Nikulina, O. I.; Belyatskaya, A. V.; Kharitonov, Yu. Ya.; Grikh, V. V.; Korol, L. A.; Obidchenko, Yu. A.; Воробьев, А. Н.

doi:10.1007/s11094-015-1310-0

Cited by 4 publications

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“…Tablets are solid dosed medicinal forms developed by compressing a drug or a blend of a drug and excipients or formed special masses (powers, granules), intended for internal, external, sublingual, or parenteral use. [19] The main benefit of these medicinal forms is the high production rate, the wide range of possibilities for masking color and odor, and the potential for prolonging drug action, not to mention portability and ease of use. [20] The major disadvantage of these conventional solid dosage forms having to chew and swallowing difficulty (dysphagia).…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Polyherbal Fast Dissolving Tablet of Curcumin, Quercetin and Rutin

Tiwari

Mahmood

et al. 2021

Int. J. Pharm. Sci. Drug Res.

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The current study was focused on the design, development, and evaluation of the fast-dissolving tablet of a polyherbal combination of curcumin, quercetin, and rutin. These herbal drugs are poorly water-soluble. The center of attention for this study is to provide quick onset of action, improved bioavailability, and increased patient compliance for administering a tablet. All parameters of Polyherbal Fast dissolving tablets were evaluated, and all were found within the official range. Drug content ranges between 90 to 105%. The formulation PHT24 containing a high concentration of Crosspovidone enhanced the drug release up to 94% within 5 minutes compared with the control. The optimized formula PHT24 showed favorable drug dissolve characteristics with better mouth feel and acceptable fast-dissolving properties. It was also observed that all formulations were acceptable with reasonable limits of the standard required for fast-dissolving tablets. The study also reveals that the Superdisintegrants used were effective in low or high concentrations. It was concluded that fast dissolving tablets with enhanced dissolution rates could be made using selected Superdisintegrants

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Section: Introductionmentioning

confidence: 99%