Preparation and performance of a poly(ethyleneimine) embedded N-acetyl-L-phenylalanine mixed-mode stationary phase for HPLC

Wan, Meijun; Luo, Qiurong; Ren, Xiujun; Zheng, Yunchao; Gao, Die; Fu, Qifeng; Zu, Fengjiao; Xia, Zhining; Wang, Lujun

doi:10.1016/j.microc.2020.105021

Cited by 26 publications

(9 citation statements)

References 33 publications

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“…A new CSP based on poly(ethyleneimine) with N -acetyl-L-phenylalanine moieties were introduced by Wan et al [ 69 ]. The chiral selector was immobilized onto silica gel using EDC and N -hydroxysuccinimide (NHS) ( Scheme 4 ).…”

Section: Immobilization Methodsmentioning

confidence: 99%

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Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods

et al. 2021

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Enantioselective chromatography is one of the most used techniques for the separation and purification of enantiomers. The most important issue for a specific successful enantioseparation is the selection of the suitable chiral stationary phase (CSP). Different synthetic approaches have been applied for the preparation of CSPs, which embrace coating and immobilization methods. In addition to the classical and broadly applied coating and immobilization procedures, innovating strategies have been introduced recently. In this review, an overview of different methods for the preparation of coated and immobilized CSPs is described. Updated examples of CSPs associated with the various strategies are presented. Considering that after the preparation of a CSP its characterization is fundamental, the methods used for the characterization of all the described CSPs are emphasized.

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Section: Immobilization Methodsmentioning

confidence: 99%

“…The new CSP was able to enantioseparate warfarin, under the reversed-phase elution mode. FTIR, TGA and elemental analysis were applied for its characterization [ 69 ].…”

Section: Immobilization Methodsmentioning

confidence: 99%

Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods

et al. 2021

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“…Interlinked triphenylbenzene and triazene imparted both hydrophobic and hydrophilic properties to the stationary phase. to produce a PEI-embedded mixed-mode stationary phase (Ren et al, 2018;Wan et al, 2020). This modification provided phenyl moiety to the PEI polymer.…”

Section: Rplc/hilic Mixed Modementioning

confidence: 99%

“…The properties of this stationary phase were tunable by controlling the ratio of the three monomers and could influence the retention and selectivity in both RPLC and HILIC modes. PEI bonded to the silica support has been modified with glycidylphenylether and N ‐acetyl‐ l ‐phenylalanine to produce a PEI‐embedded mixed‐mode stationary phase (Ren et al, 2018; Wan et al, 2020). This modification provided phenyl moiety to the PEI polymer.…”

Section: Polar Stationary Phases For Hilicmentioning

confidence: 99%

A survey of polar stationary phases for hydrophilic interaction chromatography and recent progress in understanding retention and selectivity

Guo

2022

Biomedical Chromatography

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Various polar stationary phases are available for hydrophilic interaction chromatography (HILIC) and help drive continuous applications in biomedical, environmental, and pharmaceutical areas in the past decade. Although the stationary phases for HILIC have been reviewed previously, it is an appropriate time to take another look at the progresses made during the past 5 years. The current review provides an overview of the polar stationary phases commercially available for HILIC applications in an effort to assist scientists in selecting suitable columns. New types of stationary phases that were published in literature in the past 5 years are summarized and discussed. The trend in stationary phase research and development is also highlighted. Of particular interest is the experimental evidence for direct interactions of polar analytes with the ligands of the stationary phases under HILIC conditions. In addition, two different approaches have been developed to delineate the relative significance of the partitioning and adsorption mechanisms in HILIC, representing an important advancement in our understanding of the retention mechanisms in HILIC.

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“…Recently, several low molecular weight CSPs derived from the amino acid, amino alcohol, amine, peptoid, and binaphthol have been reported for HPLC enantiomeric separation (Figure 5) [101][102][103][104][105][106][107][108][109][110]. Ryoo and Kim [101] and Ryoo and Heo [102]prepared (R)-phenylglycinol, (R)phenylglycine, (S)-leucinol, and (S)-leucine derived CSPs (Figure 5 of C 3 symmetric CSP 10a and CSP 10b were better than those of CSP 9a and CSP 9b probably because the phenyl group attached to the amide linkage interrupts hydrogen bonding interactions between the amide hydrogen, which is replaced by the phenyl group, and the chiral analytes, thereby inducing an effective interaction at a position near the chiral center [103].…”

Section: Other Low Molecular Weight Compound-based Cspsmentioning

confidence: 99%

Recent progress in the development of chiral stationary phases for high‐performance liquid chromatography

Zhang

2021

J of Separation Science

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Separations and analyses of chiral compounds are important in many fields, including pharmaceutical production, preparation of chemical intermediates, and biochemistry. High-performance liquid chromatography using a chiral stationary phase is regarded as one of the most valuable methods for enantiomeric separation and analysis because it is highly efficient, is broadly applicable, and has powerful separation capability. The focus for development of this method is the identification of novel chiral stationary phases with superior recognition performance and good stability. The present article reviews recent progress in the development of new chiral stationary phases for high-performance liquid chromatography between January 2018 and June 2021. These newly reported chiral stationary phases are divided into three categories: small organic moleculebased (cyclodextrin and its derivatives, macrocyclic antibiotics, cinchona alkaloids, and other low molecular weight chiral molecules), macromoleculebased (cellulose and amylose derivatives, chitin and chitosan derivatives, and synthetic helical polymers) and chiral porous material-based (chiral metal-organic frameworks, chiral covalent organic frameworks, and chiral inorganic mesoporous silicas). Each type of chiral stationary phase is discussed in detail.

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Preparation and performance of a poly(ethyleneimine) embedded N-acetyl-L-phenylalanine mixed-mode stationary phase for HPLC

Cited by 26 publications

References 33 publications

Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods

Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods

A survey of polar stationary phases for hydrophilic interaction chromatography and recent progress in understanding retention and selectivity

Recent progress in the development of chiral stationary phases for high‐performance liquid chromatography

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