This paper analyzes literature data on the influence of various factors affecting the strength and durability of adhesive bonds, as well as presents a characterization of the methods described in the literature for conducting relevant studies. It is shown that one of the main characteristics of adhesive joints is the interaction at the interface between the substrate and the adhesive. The adhesive capability of a sealant largely depends on the structure of the polymer component, as well as the presence of components in the sealant that enhance this property. The structure and condition of the substrate surface significantly affect the nature of the interaction between the adhesive and the substrate. Various methods are used to determine the strength of the adhesive bond, differing in the type of applied loads and the nature of the surface fracture. An important indicator is the determination of the wetting angle of the substrate by the sealant, which characterizes the surface energy. The durability of adhesive bonds is significantly influenced by environmental factors as well as operational conditions. Moisture, atmospheric oxygen, ultraviolet radiation, and microorganisms have a particularly strong effect on the properties of polymeric sealants.