Preparation and Pharmaco-Mechanical Characterization of Ketoprofen- Polyvinyl Alcohol Cryogel for Medical Applications

Stamate, Monica Iliuta; Ochiuz, Lăcrămioara; Timofte, Daniel; Ciuntu, Bogdan Mihnea; Ghiciuc, Cristina Mihaela; Gherman, Simona; Ştefanache, Alina; Stamate, Ciprian

doi:10.37358/rc.19.3.7018

Cited by 1 publication

(2 citation statements)

References 31 publications

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“…Dissolved borax exists in the form of the borate ion, B(OH) 4 – and can bind with up to four hydroxyl groups of PVA. However, the practical application of PVA–borax hydrogels in various fields is limited because of their poor mechanical strength and viscoelastic properties . The formation of dual-network (DN) hydrogels obtained by adding secondary polymers can help to address these limitations.…”

Section: Introductionmentioning

confidence: 99%

“…However, the practical application of PVA− borax hydrogels in various fields is limited because of their poor mechanical strength and viscoelastic properties. 12 The formation of dual-network (DN) hydrogels obtained by adding secondary polymers can help to address these limitations. The nanocellulose derivatives (e.g., cellulose nanofibers) and polysaccharides (e.g., agarose) are commonly used secondary polymers for this purpose.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Stretchability and Resilience of PVA–Sucrose Composite Hydrogel and Its Application to All-In-One Supercapacitors

Kwon

Ryu

Choe

et al. 2022

ACS Appl. Energy Mater.

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Although the addition of polysaccharides such as agarose increases the mechanical strength of the poly(vinyl alcohol) (PVA) hydrogel crosslinked with borax, the stretchability and resilience of the hydrogel decrease because of the high entanglement of polymer strands. To address these adverse effects of polysaccharides, herein, we propose the use of a monomeric saccharide, sucrose. Compared with the conventional PVA−borax− agarose (PBA) hydrogel, the PVA−borax−sucrose (PBS) hydrogel exhibits considerably enhanced tensile elongation and recoverability while maintaining comparable mechanical strength because of the less restricted movement of polymer strands owing to the monomeric characteristic of sucrose bonded to them. The addition of 1 wt % sucrose allows the hydrogel to elongate up to 150% and fully recover after the removal of the pulling force; these results are considerably superior to the 87.5% elongation and 85.7% recoverability of the PBA hydrogel. The PBS hydrogel is also used as a base substrate for the electrode and electrolyte layers of a supercapacitor to obtain stretchable all-in-one energy storage devices. To impart electrical conductivity and capacitive properties, indium tin oxide nanoparticles (NPs) are incorporated into the hydrogel. We introduce the pre-hydroxylation of the NP surface, which enables the NPs to chemically bind to the polymer network, to prevent the release of the NPs from the hydrogel. The fabricated supercapacitor exhibits an areal capacitance of 7.4 μF/cm 2 at a scan rate of 50 mV/s, with a capacitance retention of 79.1% over 5000 galvanostatic charge−discharge cycles.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%