Preparation and pharmacological characterization of the enantiomers of the anticancer agent R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea: Identification of the R-enantiomer as the active eutomer

Schnekenburger, Michael; Goffin, Eric; Schoumacher, Matthieu; Tumanov, Nikolay; Mouithys-Mickalad, Ange; de Tullio, Pascal; Wouters, Johan; Lebrun, Philippe; Diederich, Marc; Pirotte, Bernard

doi:10.1016/j.ejmcr.2024.100244

European Journal of Medicinal Chemistry Reports

2025

DOI: 10.1016/j.ejmcr.2024.100244

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Preparation and pharmacological characterization of the enantiomers of the anticancer agent R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea: Identification of the R-enantiomer as the active eutomer

Michael Schnekenburger,

Eric Goffin,

Matthieu Schoumacher

et al.

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Preparation and pharmacological characterization of the enantiomers of the anticancer agent R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea: Identification of the R-enantiomer as the active eutomer

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