Preparation and physicochemical characterization of the azithromycin-Eudragit RS100 nanobeads and nanofibers using electrospinning method

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit® RS100 electrosprayed nanoformulations

“…HCl during the electrospraying procedure. These findings were in good agreement with DSC thermograms and similar previously reported results for the TA-PLGA, AZI-PLGA and MPA-Eud electrosprayed nanobeads [22][23][24].…”

“…It can be concluded that the beads formation occurs in the low concentration of solutions (1:5 and 1:10 drug:polymer ratios). The solution at the low polymer concentrations has high surface tension which leads to the dispersion of liquid jet into the divided droplets; on the contrary, the fibre formation could be dominated at the high polymer concentrations because of the increasing in the viscoelastic forces [12,[22][23][24][37][38][39]. So, therefore, the formation of fibres or beads was highly affected by polymer solution concentrations; where the size of the prepared beads is increased by increasing the solution concentration and the fibres were produced at the highest solution concentration.…”

“…The technique has various applications in microelectronics [17], optical electronics, biotechnology, environmental engineering [18], modern material and medical technologies, new DDSs and ingredients dosage fabrication in the food, cosmetic and medicine production industries [19]. Some drugs such as insulin [20], paclitaxel [21], azithromycin [22], triamcinolone acetonide [23], methylprednisolone acetate [24], ibuprofen [25], naproxen [26], etc. [27][28][29][30][31][32][33][34] have been prepared by this method.…”

“…Besides, it can adhere to the negatively charged cells, so this polymer sounds to be an opportune carrier for localized and extended delivery of the proper drugs to the various physiologic fluids [22][23][24]. There are some reports that show the application of Eud as a suitable carrier at delivery of triamcinolone acetonide [23], methylprednisolone acetate [24], azithromycine [22] and some anti-inflammatory drugs to the eye [12]. To the best of our knowledge, there is no report regarding the preparation of the water-soluble drug-Eud electrosprayed nanoformulations.…”

Anti Pneumococcal Activity of Azithromycin-Eudragit RS100 Nano-Formulations

“…By its movement to the collector, the solvent evaporates and a fine network of nanofibers or nanobeads would form on the collector. 13 AZI loaded Eudragit RS100 nano-formulations were prepared using Electrospinning in our previous published work. 13 Here we aimed to evaluate the activity of the selected nano-formulations against AZI resistant S. pneumonia and S. aureus strains in comparison with the untreated drug.…”