2016
DOI: 10.15171/ps.2016.37
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Preparation and Physicochemical Characterization of Biodegradable mPEG-PCL Core-Shell Micelles for Delivery of Artemisinin

Abstract: Background: Artemisinin is a sesquiterpene lactone chemical extract from Artemisia annua, is poorly resolvable in water and a fast-acting blood active in treating the acute attack of malaria. Methods: Artemisinin was encapsulated within mPEG-PCL micelles with a single-step nano-precipitation method, leading to formation of ART/ mPEG-PCL micelles. mPEG-PCL copolymers was characterized in vitro by HNMR, FTIR and DSC techniques. Copolymers with artemisinin were self-assembled into micelles in aqueous solution. Th… Show more

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Cited by 25 publications
(10 citation statements)
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“…Numerous drug delivery systems including PCL-PEG-PCL micelles (17), biodegradable mPEG-PCL core-shell micelles (18), nanoliposomes (19), chitosan, gelatin, and alginate nanocapsules (20), pegylated nanoliposome (21), and ordered mesoporous SBA-15 particles (22), have been so far studied and evaluated to improve solubility, bioavailability or stability of ART for its parenteral delivery into cancer cells. Nevertheless, none of these delivery systems is designed to selectively promote ART transport and its delivery to the brain tumors via blood brain barrier.…”
Section: Introductionmentioning
confidence: 99%
“…Numerous drug delivery systems including PCL-PEG-PCL micelles (17), biodegradable mPEG-PCL core-shell micelles (18), nanoliposomes (19), chitosan, gelatin, and alginate nanocapsules (20), pegylated nanoliposome (21), and ordered mesoporous SBA-15 particles (22), have been so far studied and evaluated to improve solubility, bioavailability or stability of ART for its parenteral delivery into cancer cells. Nevertheless, none of these delivery systems is designed to selectively promote ART transport and its delivery to the brain tumors via blood brain barrier.…”
Section: Introductionmentioning
confidence: 99%
“…Impressively, the prepared AHZ nanoprodrug showed a significantly increased drug loading capacity (69.6 wt %, nearly reaching the limit calculated from the molecular structure) compared to the conventional ART encapsulated nanodrugs (usually less than 40 wt %, Table S2). , …”
Section: Resultsmentioning
confidence: 99%
“…Diblock copolymers composed of hydrophilic and hydrophobic blocks with variable lengths can encapsulate hydrophobic drugs in the core of the nanomicelle and/or attach hydrophilic drugs on the surface in the aqueous medium (25). Some common polymers used in the composition of nanomicelles are poly(ethylene glycol) (PEG) (26), N-(2-hydroxypropyl) methacrylamide (HPMA) (27), poly(l-lactic acid) (PLA) (28), poly(lactic-co-glycolic acid) (PLGA) (29), polycaprolactone (PCL) (30), and chi-tosan (31,32). Most polymeric nanomicelles investigated for drug delivery applications have been used successfully in cancer.…”
Section: Contextmentioning
confidence: 99%