Preparation and properties of a novel thermo-responsive poly(N-isopropylacrylamide) hydrogel containing glycyrrhetinic acid

He, Xiyun; Yu, Shengjie; Dong, Youyu; Yan, Fanyong; Chen, Li

doi:10.1007/s10853-009-3588-3

Cited by 16 publications

(14 citation statements)

References 25 publications

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“…Then, GSE was dissolved in N, N-dimethylformamide (DMF) and added into EDA by dropping slowly to form glycyrrhetic acid amine derivatives (GA-NH 2 ). The GA-NH 2 solution of DMF reacted with acrylic acid in the presence of sulfo-NHS and EDC to synthesize glycyrrhetinic acid with vinyl monomer (AAc-GA) [10]. The chemical structure of AAc-GA is shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…However, most of the studies about GA were focused on the hepatic targeted drug delivery system (HTDDS). Therefore, as reported in our previous literature [10], GA was introduced and PNIPAAm hydrogel containing glycyrrhetinic acid (poly(NIPAAmco-AAc-GA)) was prepared to improve the biocompatibility and the hepatic affinity of the traditional PNIPAAm hydrogel.…”

Section: Introductionmentioning

confidence: 99%

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Effect of AAc-GA content on swelling behaviors of temperature-sensitive PNIPAAm-based hydrogels

Dong

Chen

et al. 2009

Front. Mater. Sci. China

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A series of temperature-sensitive poly (NIPAAm-co-AAc-GA) hydrogels were synthesized by the copolymerization of glycyrrhetinic acid with vinyl monomer (AAc-GA) and N-isopropylacrylamide (NIPAAm) in N, N-dimethylformamide (DMF). Since GA has the specific binding capacity to asialoglycoprotein receptors on the membrane of hepatocyte, the hydrogel with GA could be expected as good candidate for hepatic cell culture. The results showed that macroporous and channel network structure was formed in the hydrogel matrix. With increasing the AAc-GA content, the swelling ratios of hydrogels and lower critical solution temperature (LCST) increased because of the hydrophilic group of AAc-GA and the macroporous structure. In addition, the prepared hydrogels could respond quickly to temperature and exhibited good reversible temperature-responsive characteristics.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of AAc-GA content on swelling behaviors of temperature-sensitive PNIPAAm-based hydrogels

Dong

Chen

et al. 2009

Front. Mater. Sci. China

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“…), which can be widely applied in biomedical and biotechnological fields such as controlled drug delivery and enzyme immobilization [4][5][6]. Among them, poly(N-isopropylacrylamide) (PNI-PAM) gained much attention because it undergo a phase transition from a hydrophilic, water-swollen state to a hydrophobic, globular state when heated above its volume phase transition temperature (VPTT) at 32°C in water [7][8][9][10][11]. However, it is difficult to guide the microgels in particular parts.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of 1 D Fe3O4/P(NIPAM–MAA–MBA) nanochains with thermo- and pH-responsive shell for controlled release for phenolphthalein

Zhang

et al. 2015

J Mater Sci

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Fe 3 O 4 /poly(N-isopropylacrylamide-methacrylic acid-N,N 0 -methylenebisacrylamide)(Fe 3 O 4 /P(NIPAM-MAA-MBA)) peapod-like nanochains have been successfully synthesized by magnetic field-induced precipitation polymerization. Fe 3 O 4 microspheres modified with vinyl groups can be arranged with the direction of the external magnetic field in a line and linked permanently via P(NIPAM-MAA-MBA) coating during precipitation polymerization. The properties of 1D Fe 3 O 4 / P(NIPAM-MAA-MBA) were characterized by transmission electron microscopy, X-ray diffraction, thermogravimetric analysis (TGA), vibrating sample magnetometry, X-ray photoelectron spectroscopy, and UV-Vis spectrophotometer. Magnetic measurement revealed that these 1D peapod-like nanochains showed highly magnetic sensitivity. The thermaland pH-response of 1D magnetic Fe 3 O 4 /P(NIPAM-MAA-MBA) nanochains was investigated by the temperature/pH dependence of hydrodynamic radius of Fe 3 O 4 /P(NIPAM-MAA-MBA) microspheres. The release behavior of phenolphthalein from 1D magnetic Fe 3 O 4 /P(NIPAM-MAA-MBA) nanochains could be effectively controlled by changing the temperature/pH values.

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“…When cells are harvested using conventional cell detachment agents such as proteolytic trypsin, the cells may be irreparably damaged thus hindering consequent cell function [3][4][5][6][7][8]. In addition, cell junctions are cleaved thus rendering the cells useless for tissue regeneration purposes [7,9].…”

Section: Introductionmentioning

confidence: 99%

“…The major obstacle to using pNIPAm coatings for this desired outcome is that pNIPAm coatings tend to be poorly cell compatible, with cells resisting attaching to bare pNIPAm surfaces [9][10][11][12]. Efforts to overcome this lack of compatibility have involved the copolymerization of the NIPAm monomer with another suitably chosen monomer to attain a more biocompatible copolymer or by adding an over-layer of cell adhesion encouraging proteins to a pNIPAm coating [1,10,13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a novel thermoresponsive copolymer series and their application in cell and cell sheet regeneration

Nash

Carroll

Velasco

et al. 2012

Journal of Biomaterials Science, Polymer Edition

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A series of poly-(N-isopropyl acrylamide)-based copolymers were developed with a view to biomedical applications, specifically cell cultivation and recovery. Ethylpyrrolidone methacrylate (EPM), the monomer of poly-(ethylpyrrolidone methacrylate) (pEPM), which is itself thermoresponsive, was copolymerized with N-isopropylacrylamide in varying ratios to create this novel thermoresponsive copolymer series. Characterization indicated a moderate increase of copolymer lower critical solution temperature with increasing EPM content. Films of the copolymers successfully hosted cells to monolayer. Cells detached from the copolymers upon temperature reduction with cell to cell junctions maintained, avoiding the damage which can be caused using conventional detachment techniques. These results indicate that these copolymers are highly cell compatible and may be useful for a range of biomedical applications.

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Preparation and properties of a novel thermo-responsive poly(N-isopropylacrylamide) hydrogel containing glycyrrhetinic acid

Cited by 16 publications

References 25 publications

Effect of AAc-GA content on swelling behaviors of temperature-sensitive PNIPAAm-based hydrogels

Effect of AAc-GA content on swelling behaviors of temperature-sensitive PNIPAAm-based hydrogels

Fabrication and characterization of 1 D Fe3O4/P(NIPAM–MAA–MBA) nanochains with thermo- and pH-responsive shell for controlled release for phenolphthalein

Synthesis and characterization of a novel thermoresponsive copolymer series and their application in cell and cell sheet regeneration

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