Preparation and properties of A-B-A type block copolymer membranes consisting of poly(N-hydroxypropyl-l-glutamine) as the A component and polyisoprene as the B component

Facile synthesis of 1,4-cis-polyisoprene–polypeptide hybrids with different architectures

“…35,36 These hybrids were used as membranes, potentially for biodegradable medical applications. 37 The tensile test showed that Young's modulus decreases and the value of elongation at the breaking point increases with an increase in the content of the PI block. 38 Finally, they tested compatibility of poly(BLG-b-isoprene-b-BLG) with rabbit blood and tissue demonstrating that this material had good biocompatibility.…”

Dissipative Particle Dynamics Simulation on Self‐Assembly Behavior of Rod–Coil–Rod Triblock Copolymer in Solutions

“…The PHIC–P2VP–PHIC can self‐assemble into the lamellar structure in a good solvent for both blocks and spherical micelle in a selective solvent, respectively. As a typical rod‐like polypeptide, many kinds of block copolymers containing poly(γ‐benzyl‐ L ‐glutamate) (PBLG) are expected to be applied to biomaterials, such as GIG (G is PBLG and I is polyisoprene), and the biocompatibility of GIG depends highly on its order structure . Ogata et al investigated the correlation between solubility parameter and aggregate size of GIG copolymer in the different polar solutions.…”

“…As a typical rod-like polypeptide, many kinds of block copolymers containing poly(g-benzyl-L-glutamate) (PBLG) are expected to be applied to biomaterials, such as GIG (G is PBLG and I is polyisoprene), and the biocompatibility of GIG depends highly on its order structure. [32] Ogata et al [28] investigated the correlation between solubility parameter and aggregate size of GIG copolymer in the different polar solutions. Additionally, Chen et al [33] used self consistent field lattice techniques to study the phase behaviors of symmetrical rod-coil-rod triblock copolymer melt and found the different behaviors with the rod-coil diblock and coil-rod-coil triblock copolymers.…”

Aggregation behavior of poly(γ‐benzyl‐L‐glutamate)‐b‐polyisoprene‐b‐poly(γ‐benzyl‐L‐glutamate) rod‐coil‐rod triblock copolymer in N,N‐dimethylformamide

“…Because of these interesting properties of PBLG, many kinds of block copolymers containing PBLG blocks have been extensively researched in the recent decade 16–21. GIG copolymer is known to show the excellent bulk properties as biomaterials with good tissue and blood compatibilities,22 and is expected to be applied to clinical applications, such as drug delivery systems23 due to the unique secondary structures of PBLG. In solution, on the other hand, PBLG maintains α‐helix, that is, rod‐like conformation,24, 25 whereas PIP has the form of random coil 26, 27.…”

“…As known in the limited study on the bulk property of GIG copolymer,22, 23 its biocompatibility depends highly on its microheterophase structure. As it is expected that the aggregate structure of the copolymer in solution is retained in the solid state after solvent evaporation,6 the microheterophase structure in the solid state should be involved in the aggregation behavior in solution.…”