Preparation and Properties of Electrospun PLLA/PTMC Scaffolds

Jiang, Dengbang; Zou, Haoying; Zhang, Heng; Zhao, Wei; Yao-zhong, Lan; Yuan, Mei

doi:10.3390/polym14204406

Cited by 6 publications

(7 citation statements)

References 34 publications

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“…59,[61][62][63][64]69,143,154 Besides, PLLA lacks flexibility, elasticity, and toughness, making it unsuitable for a self-expansive cardiac occluder skeleton. 155,156 To keep the mechanical strength of the occluder for its functioning, additional locking systems are required when PLLA is used as the skeleton material in both PLLA/PDLLA and Absnow occluders. 59,[61][62][63][64][65][66] Studies have shown that the hydrophobicity and acidic products of PLLA might affect cell adhesion.…”

Section: Poly-ε-caprolactonementioning

confidence: 99%

“…[61][62][63][64]68,69,71,72 Various methods, such as surface treatment, chemical crosslinking, and blending with other materials can modify the mechanical properties, hydrophobicity, and degradation time of PLLA, making it one of the most promising candidates materials for both skeleton and fabric of bioabsorbable cardiac occluders. 143,155,[158][159][160][161] PDLLA is a copolymer composed of D-and L-lactic units its physical and biological properties can be adjusted by altering the proportions of L-and D-isomers. [162][163][164][165] Compared with PLLA, it has better flexibility, stretchability, and a faster degradation rate due to its irregular and completely amorphous structure.…”

Section: Poly-ε-caprolactonementioning

confidence: 99%

“…Nevertheless, when used as the fabric component for Absnow and modified Amplazter occluders, it demonstrated a satisfactory endothelialization process and tolerable inflammatory response, proving its feasibility as a fabric material 61–64,68,69,71,72 . Various methods, such as surface treatment, chemical crosslinking, and blending with other materials can modify the mechanical properties, hydrophobicity, and degradation time of PLLA, making it one of the most promising candidates materials for both skeleton and fabric of bioabsorbable cardiac occluders 143,155,158–161 …”

Section: Application Of Biodegradable Polymers In Absorbable Cardiac ...mentioning

confidence: 99%

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Progress of biodegradable polymer application in cardiac occluders

Xu,

Fa,

Yang

et al. 2023

J Biomed Mater Res

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Cardiac septal defect is the most prevalent congenital heart disease and is typically treated with open‐heart surgery under cardiopulmonary bypass. Since the 1990s, with the advancement of interventional techniques and minimally invasive transthoracic closure techniques, cardiac occluder implantation represented by the Amplazter products has been the preferred treatment option. Currently, most occlusion devices used in clinical settings are primarily composed of Nitinol as the skeleton. Nevertheless, long‐term follow‐up studies have revealed various complications related to metal skeletons, including hemolysis, thrombus, metal allergy, cardiac erosion, and even severe atrioventricular block. Thus, occlusion devices made of biodegradable materials have become the focus of research. Over the past two decades, several bioabsorbable cardiac occluders for ventricular septal defect and atrial septal defect have been designed and trialed on animals or humans. This review summarizes the research progress of bioabsorbable cardiac occluders, the advantages and disadvantages of different biodegradable polymers used to fabricate occluders, and discusses future research directions concerning the structures and materials of bioabsorbable cardiac occluders.

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Section: Poly-ε-caprolactonementioning

confidence: 99%

Section: Poly-ε-caprolactonementioning

confidence: 99%

Section: Application Of Biodegradable Polymers In Absorbable Cardiac ...mentioning

confidence: 99%

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Progress of biodegradable polymer application in cardiac occluders

Xu,

Fa,

Yang

et al. 2023

J Biomed Mater Res

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“…24 Alternatively, PTMC has been used to develop many elastomeric substrates that have been used for vascular, skin, and intestinal tissue engineering. 25 This material typically exhibits poor stability; however, it can be copolymerized with LA or CL to produce a stable and electrospinnable poly(trimethylene carbonate-co-L-lactide) (PTMC-LA) or poly(trimethylene carbonate-co-caprolactone) (PTMC-CL) copolymer, respectively. 26 The ratios of component polymers in PTMC-LA or PTMC-CL copolymers can be modified to change the mechanical properties or biodegradation rate of substrates produced from these copolymers.…”

Section: Introductionmentioning

confidence: 99%

“…PLCL is an elastomeric copolymer of caprolactone (CL) and lactic acid (LA) but exhibits poor cell affinity due to its lack of surface cell recognition sites . Alternatively, PTMC has been used to develop many elastomeric substrates that have been used for vascular, skin, and intestinal tissue engineering . This material typically exhibits poor stability; however, it can be copolymerized with LA or CL to produce a stable and electrospinnable poly(trimethylene carbonate- co - l -lactide) (PTMC-LA) or poly(trimethylene carbonate- co -caprolactone) (PTMC-CL) copolymer, respectively .…”

Section: Introductionmentioning

confidence: 99%

Electrospun Elastomeric Leaflet Substrates that Structurally and Mechanically Mimic Human Aortic Valve Leaflets

Snyder

Jana

2023

ACS Appl. Polym. Mater.

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Creating leaflet substrates that accurately mimic the trilayered structure, anisotropic tensile characteristics, and elastomeric features of native human heart valve leaflets is essential to the success of heart valve tissue engineering. Earlier leaflet substrates have successfully replicated the mechanical properties of animal (porcine) heart valve leaflets. However, not one of them has been able to simultaneously replicate the trilayered structure and the highly anisotropic and elastomeric mechanical properties of human aortic heart valve leaflets. In this study, we employed a combination of polymers − polycaprolactone (PCL), poly-(trimethylene carbonate-co-L-lactide) (PTMC-LA), and poly-(trimethylene carbonate-co-caprolactone) (PTMC-CL) − in an electrospinning system to create elastomeric trilayer PCL/PTMC leaflet substrates that possess mechanical, flexural, and anisotropic properties similar to those of human native heart valve leaflets. We then compared these substrates with non-elastomeric trilayer PCL leaflet substrates to determine their effect on leaflet tissue engineering. Porcine valvular interstitial cells (PVICs) were cultured on these substrates for 1 month in static conditions to develop trilayer PCL and PCL/PTMC cell-cultured constructs. The PCL/PTMC substrates exhibited lower crystallinity and hydrophobicity than the PCL substrate, resulting in better cell adhesion and infiltration. The PCL/PTMC substrates demonstrated significantly greater cell proliferation, extracellular matrix production, and preferable gene and protein expression than the PCL substrates. Furthermore, in an osteogenic environment, the PCL/PTMC substrates showed superior resistance to calcification compared to the PCL substrates. The development of trilayer PCL/PTMC substrates with mechanical and structural characteristics resembling native tissue enhances leaflet tissue engineering.

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