Preparation and properties of inhalable nanocomposite particles: Effects of the temperature at a spray-dryer inlet upon the properties of particles

Tomoda, Keishiro; Ohkoshi, Takumi; Kawai, Yusaku; Nishiwaki, Motoko; Nakajima, Taro; Makino, Kimiko

doi:10.1016/j.colsurfb.2007.07.016

Cited by 45 publications

(31 citation statements)

References 17 publications

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“…Third, this NP system itself is not suitable for inhalant therapy, because it is known that most inhaled NPs are exhaled rather than being delivered into the lung. 28 In contrast, microparticles with aerodynamic diameters between 2 and 8 m reach small bronchi. However, the microparticles are easily recognized and eliminated by the mucociliary clearance system and alveolar macrophages immediately after they reach the small bronchi.…”

Section: Discussionmentioning

confidence: 99%

“…However, the microparticles are easily recognized and eliminated by the mucociliary clearance system and alveolar macrophages immediately after they reach the small bronchi. 28 In contrast, polymeric NPs escape the clearance system of the lung when they are delivered into small bronchi and are, thus, taken up by alveoli, macrophages, and pulmonary small vessels. Therefore, to use this NP system for inhalant therapy, we need to develop the nanocomposite microsized particles 28 that will decompose to NPs after reaching the small bronchi.…”

Section: Discussionmentioning

confidence: 99%

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Nanoparticle-Mediated Delivery of Nuclear Factor κB Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension

et al. 2009

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Abstract-Pulmonary arterial hypertension (PAH) is an intractable disease of the small pulmonary artery that involves multiple inflammatory factors. We hypothesized that a redox-sensitive transcription factor, nuclear factor B (NF-B), which regulates important inflammatory cytokines, plays a pivotal role in PAH. We investigated the activity of NF-B in explanted lungs from patients with PAH and in a rat model of PAH. We also examined a nanotechnology-based therapeutic intervention in the rat model. Immunohistochemistry results indicated that the activity of NF-B increased in small pulmonary arterial lesions and alveolar macrophages in lungs from patients with PAH compared with lungs from control patients. In a rat model of monocrotaline-induced PAH, single intratracheal instillation of polymeric nanoparticles (NPs) resulted in delivery of NPs into lungs for Յ14 days postinstillation. The NP-mediated NF-B decoy delivery into lungs prevented monocrotaline-induced NF-B activation. Blockade of NF-B by NP-mediated delivery of the NF-B decoy attenuated inflammation and proliferation and, thus, attenuated the development of PAH and pulmonary arterial remodeling induced by monocrotaline. Treatment with the NF-B decoy NP 3 weeks after monocrotaline injection improved the survival rate as compared with vehicle administration. In conclusion, these data suggest that NF-B plays a primary role in the pathogenesis of PAH and, thus, represent a new target for therapeutic intervention in PAH. This nanotechnology platform may be developed as a novel molecular approach for treatment of PAH in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nanoparticle-Mediated Delivery of Nuclear Factor κB Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension

et al. 2009

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“…After reaching the alveoli, the microparticles were decomposed to nanoparticles, as lactose is soluble in the alveolar lining fluid [205,[212][213][214].…”

Section: Use Of Lactose As An "Excipient"mentioning

confidence: 99%

Lactose characteristics and the generation of the aerosol

Pilcer¹,

Wauthoz²,

Amighi³

2012

Advanced Drug Delivery Reviews

179

113

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“…The conjugated NPs showed an increase in drug residence in plasma for a number of days [58]. The inhalable dry powder formulations of rifampicin in PLGA nanocarriers have also been reported [12,59,60]. A Nano in a microsystem in an inhaled dry powder form containing Clarithromycin (CLR) loaded on PLGA NPs [61].…”

Section: Plga Based Nps Containing Atdsmentioning

confidence: 99%

Drug-Resistant Tuberculosis: Recent Approach in Polymer Based Nanomedicine

Shaji

Shaikh

2016

Int J Pharm Pharm Sci

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Tuberculosis (TB) had been a leading chronic bacterial infection since decades. Current therapeutic management of Mycobacterium tuberculosis (MTB) is inadequate due to the lengthy course of treatment, drug-related side effects and ill-planned therapy, and these factors can lead to therapeutic failure and the emergence of drug-resistant TB. The Multi-drug-resistant (MDR) TB needs a lengthy course of treatment with secondline antitubercular drugs (ATDs) having higher side effects and cost. The misuse of second-line ATDs may result in extremely drug-resistant (XDR) strain which is very difficult to treat and require high doses of drugs resulting in more toxicity and side effects. This review highlights the need for novel drug delivery for the treatment of drug-susceptible and resistant TB. The characteristics of the nanoparticulate system in ATDs delivery and its approach in the MDR and XDR TB are discussed. The lung is the site of infection in pulmonary TB and the targeted drug delivery to the site of infection helps in achieving increased efficacy with less dose further reducing the side effects and toxicity. The symbiotic association of nanotechnology and pulmonary drug delivery give rise to an efficient inhalable polymer based nanoparticulate system containing ATDs for the better management of drug-susceptible and resistant TB. Various ATDs loaded polymer based nanocarrier systems like Alginate, PLGA, Chitosan and Gelatin nanocarriers are discussed in detail. Thus, this review highlights the current research in pulmonary drug delivery of polymer based ATDs nanomedicine and their importance in control of drug-resistant TB.

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Preparation and properties of inhalable nanocomposite particles: Effects of the temperature at a spray-dryer inlet upon the properties of particles

Cited by 45 publications

References 17 publications

Nanoparticle-Mediated Delivery of Nuclear Factor κB Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension

Nanoparticle-Mediated Delivery of Nuclear Factor κB Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension

Lactose characteristics and the generation of the aerosol

Drug-Resistant Tuberculosis: Recent Approach in Polymer Based Nanomedicine

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