Preparation and properties of nanoparticles of calcium phosphates with various Ca/P ratios

Sun, Limin; Chow, Laurence C.; Frukhtbeyn, Stanislav A.; Bonevich, John E.

doi:10.6028/jres.115.018

Cited by 108 publications

(69 citation statements)

References 34 publications

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“…Previously published studies have reported that a characteristic mass loss is observed in the TGA spectra of calcium phosphate nanoparticles at both 200°C and 400°C that corresponds to loss of adsorbed water and pyrophosphate formation. 24 The TGA analysis of chitosan-sodium tripolyphosphate nanoparticles was performed in another study, and it was reported that the maximum loss of weight occurs at the temperature range of 225°C-530°C. 25 Meanwhile, studies have also reported that the maximum weight loss in TGA spectra of alginate is observed at 400°C.…”

Section: +2mentioning

confidence: 99%

Oral administration of iron-saturated bovine lactoferrin–loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism

Mahidhara¹,

Kanwar²,

Roy³

et al. 2015

IJN

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We determined the anticancer efficacy and internalization mechanism of our polymeric–ceramic nanoparticle system (calcium phosphate nanocores, enclosed in biodegradable polymers chitosan and alginate nanocapsules/nanocarriers [ACSC NCs]) loaded with iron-saturated bovine lactoferrin (Fe-bLf) in a breast cancer xenograft model. ACSC-Fe-bLf NCs with an overall size of 322±27.2 nm were synthesized. In vitro internalization and anticancer efficacy were evaluated in the MDA-MB-231 cells using multicellular tumor spheroids, CyQUANT and MTT assays. These NCs were orally delivered in a breast cancer xenograft mice model, and their internalization, cytotoxicity, biodistribution, and anticancer efficacy were evaluated. Chitosan-coated calcium phosphate Fe-bLf NCs effectively (59%, P ≤0.005) internalized in a 1-hour period using clathrin-mediated endocytosis ( P ≤0.05) and energy-mediated pathways ( P ≤0.05) for internalization; 3.3 mg/mL of ACSC-Fe-bLf NCs completely disintegrated (~130-fold reduction, P ≤0.0005) the tumor spheroids in 72 hours and 96 hours. The IC 50 values determined for ACSC-Fe-bLf NCs were 1.69 mg/mL at 10 hours and 1.62 mg/mL after 20 hours. We found that Fe-bLf-NCs effectively ( P ≤0.05) decreased the tumor size (4.8-fold) compared to the void NCs diet and prevented tumor recurrence when compared to intraperitoneal injection of Taxol and Doxorubicin. Receptor gene expression and micro-RNA analysis confirmed upregulation of low-density lipoprotein receptor and transferrin receptor (liver, intestine, and brain). Several micro-RNAs responsible for iron metabolism upregulated with NCs were identified. Taken together, orally delivered Fe-bLf NCs offer enhanced antitumor activity in breast cancer by internalizing via low-density lipoprotein receptor and transferrin receptor and regulating the micro-RNA expression. These NCs also restored the body iron and calcium levels and increased the hematologic counts.

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Section: +2mentioning

confidence: 99%

Oral administration of iron-saturated bovine lactoferrin–loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism

Mahidhara¹,

Kanwar²,

Roy³

et al. 2015

IJN

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“…Such enhancers include aliphatic acids, fatty acids, esters, alcohols, oils and terpens 1 and also variety of nanoparticle including elemental or polymeric nanoparticles [7][8][9][10][11][12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2014

IJPSR

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ABSTRACT:Objectives: Transdermal drug delivery suggests several advantages and has been vastly investigated over last decades. Chemical enhancers improve the quantity of drug penetration through the skin. In this study, hydrophilic solvents have been used as enhancers to promote dermal penetration of albumin. Methods: 20 different formulations containing albumin and hydrophilic solvents were prepared. Transdermal absorption experiments for each formulation were performed using a diffusion cell and a slice of chicken skin as model at 32°C for 3 hours. Samples from the medium were withdrawn and analyzed for albumin concentration. Cumulative amounts of albumin were plotted for each formulation. Results: After 3 hours, 6.8, 5.8, 69.0, 7.9, 11.1, 25.2, 32.0, 98.0, 21.3 and 74.3 mg of albumin were passed through the skin, using formulations containing deionized water (DW), acetic acid, ethyl acetate (EA), methanol, ethanol, 2-propanol, isopropyl alcohol (IPA), glycerol, ethylene glycol (EG) and propylene glycol (PG), respectively. Conclusion: PG, EA and glycerol could act as enhancers for transdermal delivery of albumin. Such delivery was increased using 4 mL of them instead of 2 mL and using exposure time of 3 hours instead of 1.5 hours. The most effective enhancer was found glycerol, showing a maximum albumin permeation of 98.0 mg. Therefore, the study suggested using glycerol as enhancer for transdermal delivery of albumin or other similar proteins in cosmeceutical products.

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“…To address these problems, the Maryland Bridge was developed in the late 1970s; It was easy to place and strong, since it does not use the retention holes in the retainers. However, it also had disadvantages: a complicated electrode etching procedure is required and can only be used with nickel-chromium alloys [14,15].…”

Section: An Example Of Macromechanical Retention Is What Was Donementioning

confidence: 99%

Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

Estrada

2017

IJRRT

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A descriptive bibliographic review of the evidence provided in indexed articles and other bibliographic sources, such as books, theses and others, has been made. These were analyzed and after checking whether or not they met the inclusion/exclusion criteria of this work, finally were 27 articles of bibliographic review published in a hairpin that goes from 2007 to 2016. IntroductionThe use of metals in dentistry has great therapeutic advantages in many fields of dentistry, such as orthodontics, prostheses, conservative dentistry since its origins and more recently implantology [2]. Likewise, metals can be used on numerous and varied substrates: enamel, dentin, ceramics, resins or other metals [1]. Examples of adhesion of enamel or dentin to metals, orthodontic bands and brackets, or Maryland type adhesive bridges. It may be necessary to attach a metal to ceramics in the case of a metal crown, which by aesthetics will be covered or another metal (such as a cast post) to the metal of the crown and / or ceramics thereof, or even when it is free of metal [4].The first and foremost objective of dental adhesives is the long-lasting attachment to their substrates or adhesives, whether hard dental tissues or a wide range of materials (some new and others already contaminated when already in the mouth). The adhesive system, already discovered by Bouncoure and Bowen in the 1960s, has meant an improvement in speed, efficiency and convenience by simplifying the joining steps of two bodies of disparate origin and nature and reducing the time in the clinician's working time. The current trend in the development of dental adhesive systems follows the line of self-etch adhesives, multipurpose primers or adhesives that give a strong and durable adhesion indiscriminately to a multitude of adherents that coexist in the oral environment, ranging from tejdios (Enamel and dentin), precious metals (noble), alloys of precious metals and alloys of non-precious metals to dental porcelain, ceramics based on aluminum oxide (alumina) and zirconium-based ceramics [6,7].Do not overlook the many detractors of self-etch adhesives. On the one hand self-etching adhesives are easy to use and less prone to cause postoperative sensitivity. Although on the other hand, AbstractThe use of metals in dentistry presupposes the need for mechanisms of retention or adhesion of the same to different substrates; Such as enamel, dentin, ceramics, old resins and other metals [1].Throughout history these mechanisms have been changing and evolving, from the purely mechanical retention to the present mechanisms of adhesion [2,3]. It is in the decade of the 70 when they begin to develop adhesion materials. Prior to this, retention was basically mechanical, having also evolved from macromechanical retention systems to micromechanical retention systems [3]. It is at the end of the 70 when the first generation of adhesives appears; These monomers were 4-META (4-methacryloyloxyethyl trimellitate anhydride) and 10-MDP (10-methacryloyloxydecyl dihydrogen phosphate). Thes...

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Preparation and properties of nanoparticles of calcium phosphates with various Ca/P ratios

Cited by 108 publications

References 34 publications

Oral administration of iron-saturated bovine lactoferrin–loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism

Oral administration of iron-saturated bovine lactoferrin–loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism

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Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

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Preparation and properties of nanoparticles of calcium phosphates with various Ca/P ratios

Cited by 108 publications

References 34 publications

Oral administration of iron-saturated bovine lactoferrin&ndash;loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism

Oral administration of iron-saturated bovine lactoferrin&ndash;loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism

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Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?

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Oral administration of iron-saturated bovine lactoferrin–loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism

Oral administration of iron-saturated bovine lactoferrin–loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism