Preparation and Properties of New Gastric Antacids II**Received September 2, 1959. from the Research Laboratory, Reheis Co., Inc., Berkeley Heights, N. J.

Beekman, Stewart M.; Vogel, Carl H.

doi:10.1002/jps.3030490405

Cited by 6 publications

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“…According to their claims, the resulting precipitate, which contains relaxin, can be utilized as a pharmaceutically active substance or as an antacid to alleviate gastric and intestinal disorders. Beekman and Vogel [1] innovated novel gastric antacids comprising of aluminum hydroxide combined with nonfat milk, milk protein concentrate, whole milk, egg albumin, lactalbumin, gelatin, and a soy milk product. Thesiya., et al [11] have recently been awarded a patent for their milk protein-based antacid tablets.…”

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confidence: 99%

Milk as an Antacid in the Human System

Thesiya¹

2023

Act Sci VetSci

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mentioning

confidence: 99%

Milk as an Antacid in the Human System

Thesiya¹

2023

Act Sci VetSci

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2D Layered Double Hydroxide Nanoparticles: Recent Progress toward Preclinical/Clinical Nanomedicine

et al. 2019

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2D nanomaterials represent one of the next‐generation biomaterials with versatile physicochemical advantages that allow for diverse biomedical applications in disease diagnosis, prevention, and treatment. In particular, layered double hydroxide (LDH) nanoparticles, as a typical 2D nanomaterial, have recently shown unprecedented advances in controllable and simplified chemical construction, versatile surface engineering, and comprehensive biological investigation. To realize in vivo biomedical applications, recent efforts have been substantially devoted to a few critical aspects of LDH nanomedicine including nanoparticle stability in physiological environments, accumulation at the disease‐targeted site, selective biological response to the nanoparticle, systematic biosafety examination, integration with multiple diagnostic and therapeutic modalities, and the adjuvant activity and suitability for gene‐based and protein‐based vaccines, which are herein comprehensively reviewed. The challenges and future development strategies of LDH nanomedicine are also discussed toward practical biomedical applications to benefit patients.

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Beyond Drug Delivery System: Immunomodulatory Layered Double Hydroxide Nanoadjuvants Take an Essential Step Forward in Cancer Immunotherapy

Zhu

Jiang²,

Jia³

et al. 2023

Acc. Mater. Res.

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Conspectus Layered double hydroxide (LDH) is an anionic two-dimensional plate-like nanomaterial consisting of positively charged divalent and trivalent cation layers and anion-exchangeable interlayer galleries alternatingly. In the past decades, LDH has been widely explored as a versatile drug delivery system (DDS) for delivering small molecules, genes, peptides, and proteins due to its excellent drug-loading capacity and feasible surface modification. At the cellular level, LDH can be easily internalized by cells, escape rapidly (<30 min) from endosomes/lysosomes, and subsequently diffuse into the cytoplasm and mitochondria, which provides an important basis for achieving subcellular organelle-targeted drug delivery. At the body level, LDH is able to actively target different organs by optimizing the physicochemical properties (e.g., size and colloidal stability) and surface modification. Beyond DDS, LDH has been used as an antacid drug Talcid for nearly half a century, and its chemical composition is also highly similar to commercial aluminum adjuvants; thus, LDH has been redefined as a new type of antacid nanoaluminum adjuvant for cancer immunotherapy. Notably, the flexible composition of LDH enables its metal cations and defect sites in the LDH layer to be tailored according to the needs of cancer immunotherapy. On the one hand, doping nutritional metal cations into LDH layers can greatly enhance the ability of LDH to activate immune cells and induce tumor immunogenic cell death, thereby improving its efficiency in inducing systemic immune responses. On the other hand, the modulation of defect sites in the crystal structure of LDH enables itself to sensitively respond to external stimuli for photothermal/photodynamic therapy, sonodynamic therapy, and pH-sensitive magnetic resonance imaging. Therefore, two-dimensional LDH nanomaterials with high physicochemical plasticity are emerging as drug-free or drug-minimal candidates for visualized cancer immunotherapy. In this Account, we briefly introduce the application of LDH as DDS in delivering small molecules, genes, peptides, proteins, and vaccines against malignant tumors, as well as the related surface modification strategies for enhancing LDH-based nanomedicine/vaccine accumulation in the targeted tissues. Then, we highlight our group’s work in preparing drug-free or drug-minimal LDH for efficient cancer immunotherapy beyond DDS. We are focusing on exploring the influence of the intrinsic physicochemical properties of LDH on its activation of the immune system, induction of tumor cell death, and evocation of protective antitumor immune responses. The perspectives associated with the application of immunomodulatory LDH for visualized cancer immunotherapy are also discussed. We envision that these drug-free or drug-minimal LDH nanomaterials for cancer immunotherapy will stimulate the development of simple and highly effective immunomodulatory nanomaterials to fight cancer.

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Preparation and Properties of New Gastric Antacids II**Received September 2, 1959. from the Research Laboratory, Reheis Co., Inc., Berkeley Heights, N. J.

Cited by 6 publications

References 0 publications

Milk as an Antacid in the Human System

Milk as an Antacid in the Human System

2D Layered Double Hydroxide Nanoparticles: Recent Progress toward Preclinical/Clinical Nanomedicine

Beyond Drug Delivery System: Immunomodulatory Layered Double Hydroxide Nanoadjuvants Take an Essential Step Forward in Cancer Immunotherapy

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