Preparation and Properties of New Gastric Antacids III

Beekman, Stewart M.

doi:10.1002/jps.2600500708

Cited by 2 publications

(3 citation statements)

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“…Imject Alum is a commercial aluminum adjuvant for promoting antibody immune response, which has been found to convert to magnesium and aluminum layered double hydroxide (MgAl-LDH) via simply thermal hydrolysis. Interestingly, a typical LDH with the formula of Mg 6 Al 2 (OH) 16 CO 3 ·4H 2 O is named Talcid and has been clinically used for neutralizing excess stomach acid . Thereafter, the successful preparation of nanoscale LDH by our and Duan’s group in the early 2000s , initiated the application of LDH as DDS in the field of delivering small molecule drugs, genes and proteins for cancer chemotherapy, antioxidant therapy, photothermal therapy, photodynamic therapy, gene therapy, and immunotherapy. − Differently, LDH owns a positively charged surface and a high surface-to-volume ratio, rendering itself to readily load large quantities of immunomodulators and antigens through simple mixtures to evoke potent cancer immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Beyond Drug Delivery System: Immunomodulatory Layered Double Hydroxide Nanoadjuvants Take an Essential Step Forward in Cancer Immunotherapy

Zhu

Jiang²,

Jia³

et al. 2023

Acc. Mater. Res.

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Conspectus Layered double hydroxide (LDH) is an anionic two-dimensional plate-like nanomaterial consisting of positively charged divalent and trivalent cation layers and anion-exchangeable interlayer galleries alternatingly. In the past decades, LDH has been widely explored as a versatile drug delivery system (DDS) for delivering small molecules, genes, peptides, and proteins due to its excellent drug-loading capacity and feasible surface modification. At the cellular level, LDH can be easily internalized by cells, escape rapidly (<30 min) from endosomes/lysosomes, and subsequently diffuse into the cytoplasm and mitochondria, which provides an important basis for achieving subcellular organelle-targeted drug delivery. At the body level, LDH is able to actively target different organs by optimizing the physicochemical properties (e.g., size and colloidal stability) and surface modification. Beyond DDS, LDH has been used as an antacid drug Talcid for nearly half a century, and its chemical composition is also highly similar to commercial aluminum adjuvants; thus, LDH has been redefined as a new type of antacid nanoaluminum adjuvant for cancer immunotherapy. Notably, the flexible composition of LDH enables its metal cations and defect sites in the LDH layer to be tailored according to the needs of cancer immunotherapy. On the one hand, doping nutritional metal cations into LDH layers can greatly enhance the ability of LDH to activate immune cells and induce tumor immunogenic cell death, thereby improving its efficiency in inducing systemic immune responses. On the other hand, the modulation of defect sites in the crystal structure of LDH enables itself to sensitively respond to external stimuli for photothermal/photodynamic therapy, sonodynamic therapy, and pH-sensitive magnetic resonance imaging. Therefore, two-dimensional LDH nanomaterials with high physicochemical plasticity are emerging as drug-free or drug-minimal candidates for visualized cancer immunotherapy. In this Account, we briefly introduce the application of LDH as DDS in delivering small molecules, genes, peptides, proteins, and vaccines against malignant tumors, as well as the related surface modification strategies for enhancing LDH-based nanomedicine/vaccine accumulation in the targeted tissues. Then, we highlight our group’s work in preparing drug-free or drug-minimal LDH for efficient cancer immunotherapy beyond DDS. We are focusing on exploring the influence of the intrinsic physicochemical properties of LDH on its activation of the immune system, induction of tumor cell death, and evocation of protective antitumor immune responses. The perspectives associated with the application of immunomodulatory LDH for visualized cancer immunotherapy are also discussed. We envision that these drug-free or drug-minimal LDH nanomaterials for cancer immunotherapy will stimulate the development of simple and highly effective immunomodulatory nanomaterials to fight cancer.

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Section: Introductionmentioning

confidence: 99%

Beyond Drug Delivery System: Immunomodulatory Layered Double Hydroxide Nanoadjuvants Take an Essential Step Forward in Cancer Immunotherapy

Zhu

Jiang²,

Jia³

et al. 2023

Acc. Mater. Res.

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“…investigations carried out by Dandiya, et al (3,4), showed that the activity of the drug was due to the steam volatile oil. Their main findings are that the oil potentiated the hypnotic activity of barbiturates and ethanol, exacerbated the tonic seizures provoked by convulsive doses of metrazol, reduced the amphetamine toxicity, and caused hypothermia.…”

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confidence: 98%

“…The excellent antacid properties of the AHMT dried gels repared by our process are contrasted with the results exhibited by usual dry Elends of aluminum hydroxide dried gel with magnesium trisilicate powder. HE THREE preceding papers (1)(2)(3) in this Tseries of in oifro studies described mixtures of aluminum hydroxide with (a) magnesium carbonate, (b) various proteins and protein products including nonfat milk, and (c) glycine. All were new combinations of old antacids by new processes.…”

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confidence: 99%

Preparation and Properties of New Gastric Antacids IV

Beekman¹

1961

Journal of Pharmaceutical Sciences

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Preparation and Properties of New Gastric Antacids III

Cited by 2 publications

References 3 publications

Beyond Drug Delivery System: Immunomodulatory Layered Double Hydroxide Nanoadjuvants Take an Essential Step Forward in Cancer Immunotherapy

Beyond Drug Delivery System: Immunomodulatory Layered Double Hydroxide Nanoadjuvants Take an Essential Step Forward in Cancer Immunotherapy

Preparation and Properties of New Gastric Antacids IV

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