Preparation and properties of redox responsive modified hyaluronic acid hydrogels for drug release

Zhang, Renyi; Li, Xian; He, Kewen; Sheng, Xueying; Deng, Shuang; Shen, Yue-Qin; Chang, Guanjun; Ye, Xu

doi:10.1002/pat.4059

Cited by 31 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As mentioned in Section , in recent years, hydrogels have attracted increasing interest due to their broad range of applications in areas such as tissue engineering, drug delivery systems, sensors, and implant materials . Particularly, redox‐responsive hydrogels, which undergo reversible volume phase‐transition or sol–gel phase‐transition in response to the reduction potential, have great potential in biomedical and biotechnological applications …”

Section: Applicationsmentioning

confidence: 99%

Sulfur Chemistry in Polymer and Materials Science

Mutlu

Ceper

et al. 2018

Macromol. Rapid Commun.

278

220

View full text Add to dashboard Cite

The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/marc.201800650. ChemistryBefore moving to the recent advances within the last 5 years in the diverse applications of sulfur chemistry in polymer and Sulfur-Containing PolymersSulfur and its functional groups are major players in an area of exciting research taking place in modern polymer and materials science, both in academia and industry. In fact, manifold sulfur-based reactions that are both exceptionally versatile as well as tremendously useful have been implemented, and further utilized for the design and preparation of polymeric materials that lead to a plethora of applications ranging from medicine to optics and nanotechnology to separation science. Hence, within this review, an overview of strategies and developments used over the last 5 years to reinforce the importance of the sulfur functional group in modern polymer and materials science is presented. In particular, many important references in the primary literature of sulfur chemistry are referred to, including thiol-ene, thiol-yne, thiol-Michael addition, disulfide cross-linking, and thiol-disulfide exchange, among others, by explaining and illustrating the important principles. Last but not least, the grand aim to underpin the importance of sulfur in modern polymer and materials science is achieved by presenting selected examples in diverse fields and postulating the respective potential for real-world applications. he is now a full professor at KIT.sulfur atoms, and tetraphenylethene-bearing di(alkyl bromide) (Scheme 3). The yield of the polymerization was dependent on the di(alkyl bromide) monomer; the longer spacer between the aromatic moiety and the reactive bromide end groups Scheme 1. The discussion henceforth focuses on the synthesis of polymers possessing the depicted sulfur functional groups. Scheme 2.Representative examples of polythioethers prepared via A) the nucleophilic substitution reaction between an electrophilic dihalide with nucleophilic derivatives of dithiols under alkaline conditions; B) the thiol-ene/yne addition reaction between AA and BB type monomers (i.e., dithiols and dienes/diynes); and C) radical or ionic ring-opening of sulfurcontaining strained rings.Scheme 3. The thiol-bromo polymerization of conformationally fixed monomers to provide multifunctional polymers. [19] Macromol. Rapid Commun. 2019, 40, 1800650 Scheme 4. The regioselective selective nucleophilic aromatic substitution between thiol and fluorinated aromatic compounds, the para-fluorothiol reaction (PFTR).Scheme 5. Synthesis of a linear polymer via PFTR-reaction. [21]

show abstract

Section: Applicationsmentioning

confidence: 99%

Sulfur Chemistry in Polymer and Materials Science

Mutlu

Ceper

et al. 2018

Macromol. Rapid Commun.

278

220

View full text Add to dashboard Cite

show abstract

“…A variety of nano‐sized drug delivery systems (DDS) have been designed to increase the bioavailability of antitumor drugs, improve drug delivery efficiency to specific sites, and enhance antitumor efficacy of drugs . Resesarch interests have been focused on the development of pH‐responsive drug carriers, taking advantage of the weak acidity characteristic (ie, pH 6.5‐7.0) outside the tumor cells and the endosomal/lysosomal acidic pH characteristic inside the tumor cells . It is interesting to note that drug carriers that are responsive to tumor acidic pH are likely to enhance the antitumor efficacy for tumors in an acidic environment, especially if their biodegradability, biocompatibility, and drug affinity conditions are suitable for clinical use.…”

Section: Introductionmentioning

confidence: 99%

pH‐responsive squeezing polysaccharidic nanogels for efficient docetaxel delivery

Noh

Lim

Lee

2019

Polymers for Advanced Techs

View full text Add to dashboard Cite

In this study, we report pH-responsive polysaccharidic nanogels comprising starch grafted with 3-(diethylamino)propylamine (DEAP, as an inner soft nanogel core) and poly(ethylene glycol) (PEG, as an outer hydrophilic nanogel shell). Here, the DEAP moieties (pK b~p H 7.0) enhance the lipophilicity of the nanogel core at pH 7.4, improving the loading efficiency of an antitumor model drug (docetaxel [DTX]) in the core. However, the DEAP moieties could be protonated below pH 7.0, resulting in the mediation of ion-dipole interactions with hydroxyl groups abundant in starch backbone. This event causes the electrostatic condensation of the nanogel core and enables the acceleration of drug release by squeezing of the core. We demonstrated that the nanogels selectively release the drug given a weakly acidic pH stimulus. These drug release trends are reversible with changes in pH. As a result, the nanogels are able to efficiently reduce MDA-MB-231 tumor cell population in acidic pH environments.

show abstract

“…Polysaccharides are a common component of hydrogels used for biomedical applications because they are cheap, degradable, their properties can be tuned (e.g., as a function of molecular weight), and they tend to be non-immunogenic [9][10][11]. Pectin (a component of cell walls of plants) [9] and hyaluronic acid (HA, a component of the extracellular matrix) [26][27][28][29][30][31] are highly hydrophilic because of the carboxylic acids displayed on their backbones, and their backbones can be oxidized to generate reactive aldehyde moieties that can react with amines forming Schiff base linkages that can form sample spanning hydrogels in periods from seconds to minutes dependent on the concentration of reactive amines/aldehydes in three-dimensional space [32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

Leone

Fırlak

Challen

et al. 2019

JFB

View full text Add to dashboard Cite

In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing.

show abstract

Preparation and properties of redox responsive modified hyaluronic acid hydrogels for drug release

Cited by 31 publications

References 32 publications

Sulfur Chemistry in Polymer and Materials Science

Sulfur Chemistry in Polymer and Materials Science

pH‐responsive squeezing polysaccharidic nanogels for efficient docetaxel delivery

In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

Contact Info

Product

Resources

About