Preparation and Properties of Some Ether and Ester Derivatives of Hydroxyethylcellulose

Cohen, Saul G.; Haas, Howard C.; Farney, Leonard; Valle, Claude

doi:10.1021/ie50517a058

Cited by 5 publications

(1 citation statement)

References 2 publications

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“…The water-soluble cellulose ethers should not be regarded simply as water-soluble forms of cellulose. The ethers are derivatives of cellulose, containing only a fraction of the original cellulose structure in their molecular make-up [70].…”

Section: Etherificationmentioning

confidence: 99%

Pharmaceutical significance of cellulose: A review

Kamel¹,

Ali²,

Jahangir³

et al. 2008

Express Polym. Lett.

382

191

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Abstract. The amalgamation of polymer and pharmaceutical sciences led to the introduction of polymer in the design and development of drug delivery systems. Polymeric delivery systems are mainly intended to achieve controlled or sustained drug delivery. Polysaccharides fabricated into hydrophilic matrices remain popular biomaterials for controlled-release dosage forms and the most abundant naturally occurring biopolymer is cellulose; so hdroxypropylmethyl cellulose, hydroxypropyl cellulose, microcrystalline cellulose and hydroxyethyl cellulose can be used for production of time controlled delivery systems. Additionally microcrystalline cellulose, sodium carboxymethyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose as well as hydroxypropyl cellulose are used to coat tablets. Cellulose acetate phthalate and hydroxymethyl cellulose phthalate are also used for enteric coating of tablets. Targeting of drugs to the colon following oral administration has also been accomplished by using polysaccharides such as hdroxypropylmethyl cellulose and hydroxypropyl cellulose in hydrated form; also they act as binders that swell when hydrated by gastric media and delay absorption. This paper assembles the current knowledge on the structure and chemistry of cellulose, and in the development of innovative cellulose esters and ethers for pharmaceuticals.

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Section: Etherificationmentioning

confidence: 99%