Preparation and properties of textile materials modified with triclosan-loaded polylactide microparticles

Abstract

A convenient and simple method for preparation of commercial nonwovens with antimicrobial properties was elaborated. The process consists in preparation of poly(L-lactide) microspheres (from poly(L-lactide) with M n = 10,560 and M w /M n = 1.39) containing triclosan (5-chloro-2-(2,4-dichlorophenoxy) phenol) and loading them onto the nonwovens. The microspheres were prepared by spray drying (D n = 3.91 μm, D w /D n = 2.43) and oil-in-water emulsification-solvent evaporation method (D n = 5.84 μm, D w /D n = 1.25). Content of triclosan in microspheres ranged from 4.65 to 4.95 wt%. The antibacterial nonwovens were prepared by padding of the fibers with the microspheres using the microsphere suspension. The resulting antibacterial nonwovens were examined using inhibition zone measurement method. Inhibition zones from 4 to 9 mm indicated that the modified nonwovens had antibacterial properties against Gram (+)-Staphylococcus aureus and Gram (À)-Klebsiella pneumoniae. Nonwovens were conditioned up to 12 months at relative humidity <5%, 50%, and 100% in desiccators and up to 6 months air-conditioning system at relative humidity = 65%. Antimicrobial activity of the modified nonwovens was examined as a function of time and air humidity. Time of conditioning has strong influence on antibacterial activity, whereas the impact of the air humidity was negligible. All nonwovens had antibacterial properties even after 12 months of conditioning.

Deposition of Copper on Poly(Lactide) Non-Woven Fabrics by Magnetron Sputtering—Fabrication of New Multi-Functional, Antimicrobial Composite Materials

“…Substantial importance in this field is played by PLA composites equipped with antibacterial additivities, in the majority organic bactericides (e.g., ampicillin [ 9 ] chlorhexidine [ 10 , 11 ], ciprofloxacin [ 12 , 13 ], doxycyclin [ 14 ], gentamycin [ 15 ], oflaxin and vancomycin [ 16 ], triclosan [ 17 , 18 , 19 ], and/or curcumin [ 20 ], etc.). Due to an established role of metal nanoparticles in medicine [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], the group of increasing importance is PLA-inorganic hybrids [ 34 ], due to their high antibacterial efficiency, simplicity and also low cost of technological preparation.…”

Antibacterial Capability of Triclosan Treated on Filter Fiber Materials

“…The appearance of bacteriostatic zone, to a certain extent, indicates that the added bacteriostatic agent (triclosan) had played a good antibacterial effect. Karaszewska et al(2017) had also found that a wide range of bacteriostatic bands also appeared around the triclosan-loaded polylactide microparticles, based on the same evaluation criteria (ISO 20645 − 2004). Besides, it has a similar results that Cui et al…”

“…In a low concentration of antibacterial research, triclosan's antibacterial performance was manifested in inhibiting bacterial growth and reducing adherence to the polymer. Triclosan as an antimicrobial preparation of textile materials had also showed a good antibacterial effect (Karaszewska et al 2017); (Cui et al 2015); (Peila et al 2013). At present, although lter materials with anti-microbe performance were ordinary, it still lacks the detailed information on the use and e cacy of triclosan as antibacterial agent applied to ventilation lter materials.…”

Biofunctionalization of Textile Materials. 2. Antimicrobial Modification of Poly(lactide) (PLA) Nonwoven Fabricsby Fosfomycin

“…Polylactide (PLA) presents polymers of multifunctional application, widely used in medical related areas [1]. PLA hybrids with antibacterial additivities (bactericide agents) provide antiseptic properties, and therefore are applied in a variety of medical applications, namely, such as bioactive fibers for drug delivery [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18], for tissue engineering applications [19][20][21][22], forwound healing materials [23][24][25][26] and membranes for efficient treatment of burns [27,28].…”