Preparation and properties of water‐soluble chitosan and polyvinyl alcohol blend films as potential bone tissue engineering matrix

Ma, Guiping; Yang, Dongzhi; Su, Dandan; Mu, Xueyan; Kennedy, John F.; Nie, Jun

doi:10.1002/pat.1415

Cited by 30 publications

(8 citation statements)

References 31 publications

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“…Because of its poor water resistance, reasonable crosslink is essential for PVA to reduce the solubility in water. Consequently, PVA has been widely applied in numerous fields, such as food packaging , biomedical applications , and functional film . Especially, various hybrid materials, which were composed of PVA and a serious of reinforcements, have generated extensive interest over the recent years .…”

Section: Introductionmentioning

confidence: 99%

Preparation, properties, and characterization of novel fine leather fibers/polyvinyl alcohol composites

Xue

Ding

2014

Polym. Compos.

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The water-based dispersion of fine leather fibers (FLF) was firstly prepared in our laboratory by high pressure homogenization. The solution casting method of water-based dispersion of FLF and polyvinyl alcohol (PVA) was used to fabricate the composite films. In this study, the influences of FLF content on the structures and properties of resulting composites were investigated systematically. Experimental results showed that there was an obvious small size effect of FLF in the composite films. Esterification and etherification reactions between FLF and PVA were confirmed by FTIR analysis; XRD and DSC analyses showed that FLF had the nucleation effect on PVA. The micrograph of SEM revealed that composite film with 40 wt% FLF content had compact internal structure and vague interface, and its value of tensile strength could reach maximum 51.8 MPa. Besides, TGA test showed that the thermal stability of composite films with FLF content beyond 30 wt% were much greater than that of PVA at temperature above 350 C. Moreover, composite films were deprived of hydrophilicity to a certain extent and the antibacterial rate of composite films with 40 wt% and 60 wt% FLF content were more than 90% totally.

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Section: Introductionmentioning

confidence: 99%

Preparation, properties, and characterization of novel fine leather fibers/polyvinyl alcohol composites

Xue

Ding

2014

Polym. Compos.

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“…On average, twenty measurements were performed per film, which was cut from four different sites. A report demonstrated that the water contact angle of blank chitosan was higher than 83 • due to its hydrophilic nature and high surface tension [76]. In order to decrease the hydrophilicity of chitosan, it was blended with PAH to impart flexibility.…”

Section: Wca Measurementsmentioning

confidence: 99%

A Smart Drug Delivery System Based on Biodegradable Chitosan/Poly(allylamine hydrochloride) Blend Films

et al. 2020

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The amalgamation of natural polysaccharides with synthetic polymers often produces fruitful results in the area of drug delivery due to their biodegradable and biocompatible nature. In this study, a series of blend films composed of chitosan (CS)/poly(allylamine hydrochloride) (PAH) in different compositions were prepared as smart drug delivery matrices. The properties of these polymeric films were then explored. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) analysis confirmed an intermolecular hydrogen bonding between CS and PAH. Atomic force microscopy (AFM) revealed improvements in surface morphology as the percentage of PAH in the blend films increased up to 60% (w/w). Water contact angle (WCA) ranged between 97° to 115°, exhibiting the hydrophobic nature of the films. Two films were selected, CTH-1 (90% CS and 10% PAH) and CTH-2 (80% CS and 20% PAH), to test for in vitro cumulative drug release (%) at 37 ± 0.5 °C as a function of time. It was revealed that for simulated gastric fluid (SGF) with pH 1.2, the cumulative drug release (CDR) for CTH-1 and CTH-2 was around 88% and 85% in 50 min, respectively. Both films converted into gel-like material after 30 min. On the other hand, in pH 7.4 phosphate buffer saline (PBS) solution, the maximum CDR for CTH-1 and CTH-2 was 93% in 90 min and 98% in 120 min, respectively. After 120 min, these films became fragments. Sustained drug release was observed in PBS, as compared to SGF, because of the poor stability of the films in the latter. These results demonstrate the excellent potential of blend films in sustained-release drug delivery systems for hydrophilic or unstable drugs.

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“…The bone composition is comprised of organic and inorganic phases and made up of proteoglycans, glycosaminoglycans, glycoprotein collagen, and calcium phosphate [11][12][13][14]. Bone also contains an extraordinary amount of hydroxyapatite (HAp), which has suitable bioactive, biocompatible, and osteoconductive biological behavior.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silver-Coated Bioactive Nanocomposite Scaffolds Based on Grafted Beta-Glucan/Hydroxyapatite via Freeze-Drying Method: Anti-Microbial and Biocompatibility Evaluation for Bone Tissue Engineering

et al. 2020

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Advancement and development in bone tissue engineering, particularly that of composite scaffolds, are of great importance for bone tissue engineering. We have synthesized polymeric matrix using biopolymer (β-glucan), acrylic acid, and nano-hydroxyapatite through free radical polymerization method. Bioactive nanocomposite scaffolds (BNSs) were fabricated using the freeze-drying method and Ag was coated by the dip-coating method. The scaffolds have been characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction analysis (XRD) to investigate their functional groups, surface morphology, and phase analysis, respectively. The pore size and porosity of all BNS samples were found to be dependent on silver concentration. Mechanical testing of all BNS samples have substantial compressive strength in dry form that is closer to cancellous bone. The samples of BNS showed substantial antibacterial effect against DH5 alpha E. coli. The biological studies conducted using the MC3T3-E1 cell line via neutral red dye assay on the scaffolds have found to be biocompatible and non-cytotoxic. These bioactive scaffolds can bring numerous applications for bone tissue repairs and regenerations.

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Preparation and properties of water‐soluble chitosan and polyvinyl alcohol blend films as potential bone tissue engineering matrix

Cited by 30 publications

References 31 publications

Preparation, properties, and characterization of novel fine leather fibers/polyvinyl alcohol composites

Preparation, properties, and characterization of novel fine leather fibers/polyvinyl alcohol composites

A Smart Drug Delivery System Based on Biodegradable Chitosan/Poly(allylamine hydrochloride) Blend Films

Synthesis of Silver-Coated Bioactive Nanocomposite Scaffolds Based on Grafted Beta-Glucan/Hydroxyapatite via Freeze-Drying Method: Anti-Microbial and Biocompatibility Evaluation for Bone Tissue Engineering

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