Preparation and property of high strength and low friction PVA-HA/PAA composite hydrogel using annealing treatment

Chen, Kai; Chen, Guangyan; Wei, Sheng Min; Yang, Xuehui; Zhang, Dekun; Xu, Longhua

doi:10.1016/j.msec.2018.05.080

Cited by 70 publications

(43 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As indicated above, both annealing and γ-radiation led to further crosslinking of the gels and improved their crystallinity. This effect limits the activity of the crosslinking points in the chains and impairs conformational changes of chain segments, explaining not only the greater difficulty of water molecules penetrating into the gel matrix [18], which results in smaller EWC values but also to the lower adhesion to the opponent materials, resulting in less friction.…”

Section: Tribological Behaviormentioning

confidence: 99%

“…Numerous approaches have been attempted to strengthen and toughen these type of biomaterials, including the incorporation of nano/microparticles (e.g., silica, hydroxyapatite, and polydopamine) [11][12][13], chemical crosslinkers (e.g., glyoxal, glutaraldehyde, acetaldehyde, or other mono-aldehydes) [14][15][16], other polymers (e.g., poly(acrylic) acid and hyaluronic acid) [17,18], or differentiated structures (e.g., fibers, nanosheets, and meshes) [19][20][21][22]. Chemical crosslinkers are often toxic, inevitably affecting the biocompatibility [20].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tough and Low Friction Polyvinyl Alcohol Hydrogels Loaded with Anti-inflammatories for Cartilage Replacement

et al. 2020

View full text Add to dashboard Cite

The development of new materials that mimic cartilage and its function is an unmet need that will allow replacing the damaged parts of the joints, instead of the whole joint. Polyvinyl alcohol (PVA) hydrogels have raised special interest for this application due to their biocompatibility, high swelling capacity and chemical stability. In this work, the effect of post-processing treatments (annealing, high hydrostatic pressure (HHP) and gamma-radiation) on the performance of PVA gels obtained by cast-drying was investigated and, their ability to be used as delivery vehicles of the anti-inflammatories diclofenac or ketorolac was evaluated. HHP damaged the hydrogels, breaking some bonds in the polymeric matrix, and therefore led to poor mechanical and tribological properties. The remaining treatments, in general, improved the performance of the materials, increasing their crystallinity. Annealing at 150 °C generated the best mechanical and tribological results: higher resistance to compressive and tensile loads, lower friction coefficients and ability to support higher loads in sliding movement. This material was loaded with the anti-inflammatories, both without and with vitamin E (Vit.E) or Vit.E + cetalkonium chloride (CKC). Vit.E + CKC helped to control the release of the drugs which occurred in 24 h. The material did not induce irritability or cytotoxicity and, therefore, shows high potential to be used in cartilage replacement with a therapeutic effect in the immediate postoperative period.

show abstract

Section: Tribological Behaviormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tough and Low Friction Polyvinyl Alcohol Hydrogels Loaded with Anti-inflammatories for Cartilage Replacement

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A,B) Plots of the compressive versus tensile strength and modulus for BC–PVA–PAMPS (this work) and other strong hydrogels (see Table S1 in the Supporting Information for data and references). [ 13–35 ] The multiple data points for BC–PVA–PAMPS are for different compositions. C) BC–PVA–PAMPS easily bears the weight of a 100 lb.…”

Section: Introductionmentioning

confidence: 99%

A Synthetic Hydrogel Composite with the Mechanical Behavior and Durability of Cartilage

Yang

Zhao

Koshut

et al. 2020

Adv Funct Materials

216

178

View full text Add to dashboard Cite

This article reports the first hydrogel with the strength and modulus of cartilage in both tension and compression, and the first to exhibit cartilage‐equivalent tensile fatigue strength at 100 000 cycles. These properties are achieved by infiltrating a bacterial cellulose (BC) nanofiber network with a poly(vinyl alcohol) (PVA)–poly(2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid sodium salt) (PAMPS) double network hydrogel. The BC provides tensile strength in a manner analogous to collagen in cartilage, while the PAMPS provides a fixed negative charge and osmotic restoring force similar to the role of aggrecan in cartilage. The hydrogel has the same aggregate modulus and permeability as cartilage, resulting in the same time‐dependent deformation under confined compression. The hydrogel is not cytotoxic, has a coefficient of friction 45% lower than cartilage, and is 4.4 times more wear‐resistant than a PVA hydrogel. The properties of this hydrogel make it an excellent candidate material for replacement of damaged cartilage.

show abstract

“…Hydrogels have been widely studied as an ideal substitute for articular cartilage and as a drug carrier. Great effort has been devoted to designing functional hydrogels with good biocompatibility [5], high mechanical strength [6], and low coefficient of friction (COF) [7,8]. Recently, many hydrogels have been developed to exhibit excellent physicochemical properties such as double-network hydrogels [9], mussel-inspired functional hydrogels [10][11][12], composite hydrogels [13], and hydrogen-bonded crosslinked hydrogels [14].…”

Section: Introductionmentioning

confidence: 99%

Gelatin-based composite hydrogels with biomimetic lubrication and sustained drug release

et al. 2021

View full text Add to dashboard Cite

The occurrence of osteoarthritis is closely related to progressive and irreversible destruction of the articular cartilage, which increases the friction significantly and causes further inflammation of the joint. Thus, a scaffold for articular cartilage defects should be developed via lubrication restoration and drug intervention. In this study, we successfully synthesized gelatin-based composite hydrogels, namely GelMA-PAM-PMPC, with the properties of biomimetic lubrication and sustained drug release by photopolymerization of methacrylic anhydride modified gelatin (GelMA), acrylamide (AM), and 2-methacryloyloxyethyl phosphorylcholine (MPC). Tribological test showed that the composite hydrogels remarkably enhanced lubrication due to the hydration lubrication mechanism, where a tenacious hydration shell was formed around the zwitterionic phosphocholine headgroups. In addition, drug release test indicated that the composite hydrogels efficiently encapsulated an anti-inflammatory drug (diclofenac sodium) and achieved sustained release. Furthermore, the in vitro test revealed that the composite hydrogels were biocompatible, and the mRNA expression of both anabolic and catabolic genes of the articular cartilage was suitably regulated. This indicated that the composite hydrogels could effectively protect chondrocytes from inflammatory cytokine-induced degeneration. In summary, the composite hydrogels that provide biomimetic hydration lubrication and sustained local drug release represent a promising scaffold for cartilage defects in the treatment of osteoarthritis.

show abstract

Preparation and property of high strength and low friction PVA-HA/PAA composite hydrogel using annealing treatment

Cited by 70 publications

References 26 publications

Tough and Low Friction Polyvinyl Alcohol Hydrogels Loaded with Anti-inflammatories for Cartilage Replacement

Tough and Low Friction Polyvinyl Alcohol Hydrogels Loaded with Anti-inflammatories for Cartilage Replacement

A Synthetic Hydrogel Composite with the Mechanical Behavior and Durability of Cartilage

Gelatin-based composite hydrogels with biomimetic lubrication and sustained drug release

Contact Info

Product

Resources

About