Preparation and purification of angiotensin‐converting enzyme inhibitory peptides from hydrolysate of shrimp (<i>Litopenaeus vannamei</i>) shell waste

Feng, Simin; Limwachiranon, Jarukitt; Luo, Zisheng; Shi, Xudan; Ru, Qiaomei

doi:10.1111/ijfs.13131

Cited by 12 publications

(2 citation statements)

References 37 publications

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“…Journal Pre-proof I-converting enzyme inhibitory activity from the shrimp shell waste [490]. The optimal Alcalase hydrolysis conditions were pH 9.5, 60 °C, 25 g L −1 substrate and 4000 U g −1 of enzyme [490].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Use of Alcalase in the production of bioactive peptides: A review

Tacias-Pascacio

Morellon‐Sterling

Siar

et al. 2020

International Journal of Biological Macromolecules

224

114

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Use of Alcalase in the production of bioactive peptides: A review

Tacias-Pascacio

Morellon‐Sterling

Siar

et al. 2020

International Journal of Biological Macromolecules

224

114

View full text Add to dashboard Cite

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“…Compared with pharmacological agents, peptides derived from natural food with high ACE inhibitory activity were preferred for their safety (Ngo et al, 2016). In consideration of this, ACE inhibitory peptides are proposed as ideal functional food supplements for human health (Feng et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

A pivotal peptide (Ile-Leu-Lys-Pro) with high ACE- inhibitory activity from duck egg white: identification and molecular docking

Chen

Guo

et al. 2022

Food Sci. Technol

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Salted duck egg white was desalted and hydrolyzed to produce angiotensin I-converting enzyme (ACE) inhibitory peptides. Single factor test and response surface design were performed to determine the best hydrolysis conditions: enzyme dosage 11875.99 U/g, substrate concentration 33.04 g/L and hydrolysis time 4 h. The fraction V (M W < 1 kDa), which exhibited the strongest ACE inhibitory activity, was characterized by HPLC-ESI-MS/MS. Eighty-three peptides were identified, and among them Ile-Leu-Lys-Pro, Ile-Asn-Ser-Trp, Ile-Arg and His-Pro-Ala were synthesized for further research. Ile-Leu-Lys-Pro exhibited the highest ACE inhibitory activity (IC 50 : 0.355 mM). The molecular docking studies revealed that nine amino acids contributed to stabilize the docking complex. The ACE inhibition of Ile-Leu-Lys-Pro and Ile-Asn-Ser-Trp were mainly attributed to Ile in N-terminal. The residues Glu362 and Ala332 were the important binding sites in molecular docking. This research expands the understanding of ACE inhibitory peptides from duck egg white as well as highlights an opportunity for recycling an otherwise discarded byproduct.Keywords: desalted duck egg white peptides (DPs); enzymatic hydrolysis; angiotensin I-converting enzyme (ACE) inhibitory peptide; electrospray ionization mass spectrometry (ESI-MS); molecular docking. Practical Application:Results in this research can be used for the intensive processing of duck egg white, especially for the recycling of salted duck egg white. The obtained polypeptide with antihypertensive activity can be used for the development of functional food and improvement of food industry.

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Bioactive peptides of marine organisms: Roles in the reduction and control of cardiovascular diseases

Du,

Xiao,

Sudo

et al. 2024

Food Science & Nutrition

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Cardiovascular diseases (CVDs) affect the quality of life or are fatal in the worst cases, resulting in a significant economic and social burden. Therefore, there is an urgent need to invent functional products or drugs for improving patient health and alleviating and controlling these diseases. Marine bioactive peptides reduce and control CVDs. Many of the predisposing factors triggering CVDs can be alleviated by consuming functional foods containing marine biopeptides. Therefore, improving CVD incidence through the use of effective biopeptide foods from marine sources has attracted increasing interest and attention. This review reports information on bioactive peptides derived from various marine organisms, focusing on the process of the separation, purification, and identification of biological peptides, biological characteristics, and functional food for promoting cardiovascular health. Increasing evidence shows that the bioactivity and safety of marine peptides significantly impact their storage, purification, and processing. It is feasible to develop further strategies involving functional foods to treat CVDs through effective safety testing methods. Future work should focus on producing high‐quality marine peptides and applying them in the food and drug industry.

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Preparation and purification of angiotensin‐converting enzyme inhibitory peptides from hydrolysate of shrimp (Litopenaeus vannamei) shell waste

Cited by 12 publications

References 37 publications

Use of Alcalase in the production of bioactive peptides: A review

Use of Alcalase in the production of bioactive peptides: A review

A pivotal peptide (Ile-Leu-Lys-Pro) with high ACE- inhibitory activity from duck egg white: identification and molecular docking

Bioactive peptides of marine organisms: Roles in the reduction and control of cardiovascular diseases

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