Preparation and Reactions of Highly Functionalized Bis-Arylzinc Reagents Using a Li(acac)-Catalyzed Iodine-Zinc Exchange

Abstract

Polyfunctional bis-arylzinc reagents are accessible via a new lithium acetylacetonate-catalyzed iodine-zinc exchange. This protocol tolerates sensitive functional groups (ketones, aldehydes or isothiocyanates) in the aryl iodides and allows the formation of highly functionalized zinc reagents. These zinc reagents can be used in a variety of catalyzed and uncatalyzed transformations.