Preparation and rectal administration of hydroxybutyl chitosan/graphene oxide composite thermosensitive hydrogel

Li, Xurui; Chen, Anqi; Liu, Yu; Li, Li

doi:10.1016/j.reactfunctpolym.2023.105608

Cited by 7 publications

(4 citation statements)

References 61 publications

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“…Furthermore, pH-responsive swelling (schematic diagram presented in Figure 5) and biodegradability were confirmed in phosphate-buffered saline and proteinase K solutions [80]. Li W. et al [79] constructed a rectal delivery system using temperature-sensitive hydroxybutyl chitosan gel cross-linked with GO with pingyangmycin as a model drug. The temperature-sensitive gels are mostly based on polyisopropyl acrylamide, poloxamer, and CS.…”

Section: Drug Deliverymentioning

confidence: 91%

“…Li W. et al [79] constructed a rectal delivery system using temperature-sensitive hydroxybutyl chitosan gel cross-linked with GO with pingyangmycin as a model drug. The temperature-sensitive gels are mostly based on polyisopropyl acrylamide, poloxamer, and CS.…”

Section: Drug Deliverymentioning

confidence: 99%

“…Because of their good biocompatibility, high permeability, and low drug toxicity, they are frequently used for injectable drug administration, oral drug delivery, rectal drug delivery, or mucosal drug delivery. The obtained material presented an effectively prolonged action time of the drug in vivo with rectal administration, and a sustained release effect [79]. Whereas, pH-responsive chitosan-based hydrogel can also be used as a drug delivery system.…”

Section: Drug Deliverymentioning

confidence: 99%

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Graphene Production and Biomedical Applications: A Review

Malisz,

Świeczko-Żurek

2023

Crystals

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Graphene is a two-dimensional nanomaterial composed of carbon atoms with sp2 hybrid orbitals. Both graphene and graphene-based composite have gained broad interest among researchers because of their outstanding physiochemical, mechanical, and biological properties. Graphene production techniques are divided into top-down and bottom-up synthesis methods, of which chemical vapor deposition (CVD) is the most popular. The biomedical applications of graphene and its composite include its use in sensors, implantology, and gene and drug delivery. They can be used for tissue engineering, anticancer therapies, and as antimicrobial agents in implant application. The biocompatibility of graphene-based nanomaterials enables their use in the field of biomedicine. This article reviews the properties of graphene, the methods used to produce it, the challenges associated with its use, and the potential applications of this material in biomedicine, regenerative medicine, and drug delivery systems.

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Section: Drug Deliverymentioning

confidence: 91%

Section: Drug Deliverymentioning

confidence: 99%

Section: Drug Deliverymentioning

confidence: 99%

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Graphene Production and Biomedical Applications: A Review

Malisz,

Świeczko-Żurek

2023

Crystals

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“…Chitosan: Temperature-sensitive hydrogels such as hydroxybutyl chitosan gel (HBC) cross-linked with graphene oxide (GO) are promising for Pingyangmycin (PYM) rectal applications. HBC/GO@PYM exhibits 8 times higher drug loading than HBC@PYM [ 25 ]. An innovative thermosensitive injectable chitosan/poloxamer-based hydrogel has been developed for cardiac tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

The Method of Direct and Reverse Phase Portraits as a Tool for Systematizing the Results of Studies of Phase Transitions in Solutions of Thermosensitive Polymers

Bakirov,

Kopishev,

Kadyrzhan

et al. 2024

Gels

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It is shown that a more than significant amount of experimental data obtained in the field of studying systems based on thermosensitive hydrophilic polymers and reflected in the literature over the past decades makes the issue of their systematization and classification relevant. This, in turn, makes relevant the question of choosing the appropriate classification criteria. It is shown that the basic classification feature can be the number of phase transition stages, which can vary from one to four or more depending on the nature of the temperature-sensitive system. In this work, the method of inverse phase portraits is proposed for the first time. It was intended, among other things, to identify the number of phase transition stages. Moreover, the accuracy of this method significantly exceeds the accuracy of the previously used method of direct phase portraits since, for the first time, the operation of numerical differentiation is replaced by the operation of numerical integration. A specific example of the application of the proposed method for the analysis of a previously studied temperature-sensitive system is presented. It is shown that this method also allows for a quantitative comparison between the results obtained by the differential calorimetry method and the turbidimetry method. Issues related to increasing the resolution of the method of direct phase portraits are discussed.

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Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

Gu,

Cui,

et al. 2024

Adv Funct Materials

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Regenerative biomedicine has emerged as a forefront area in medical research, heralding a new era of therapeutic strategies. This review delineates the integration of 2D materials (2DMs) within the area of biomedical engineering, leveraging their superior physicochemical attributes for enhance biomedical outcomes. The synergistic interaction between biomacromolecules and 2DMs is explored, demonstrating their potential to mitigate the limitations inherent to each while simultaneously augmenting their beneficial properties. In particular, incorporating 2DMs into hydrogels highlights their capability to enhance the mechanical strength of hydrogels, providing a biomimetic scaffold for tissue engineering regeneration and cancer diagnosis and therapy. An overview of the synthetic methodologies are provided for 2DMs, elucidating their interaction dynamics with biomacromolecules. The review primarily concentrates on the applications of biomacromolecule‐reinforced 2DM hydrogels across various biomedical fields, including bone tissue engineering, wound healing, neural tissue engineering, cardiac tissue engineering, as well as in the delivery of drugs and genes, cancer therapy, and biosensing technologies. Finally, the review discusses the existing challenges and future outlook for developing and using biomacromolecule‐reinforced 2DM hydrogels, underlining their transformative potential in regenerative medicine.

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Preparation and rectal administration of hydroxybutyl chitosan/graphene oxide composite thermosensitive hydrogel

Cited by 7 publications

References 61 publications

Graphene Production and Biomedical Applications: A Review

Graphene Production and Biomedical Applications: A Review

The Method of Direct and Reverse Phase Portraits as a Tool for Systematizing the Results of Studies of Phase Transitions in Solutions of Thermosensitive Polymers

Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

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