Preparation and Ring Opening of 2-Methoxy-6-methyl-2-phenyl-1-ox-6-azaspiro[2.5]octane, an Epoxyether¹

Abstract

The title compound (II) was prepared by the reaction of l-methyl-4-halo-4-piperidyl phenyl ketone hydrohalide with bases in absolute alcohol. Unlike the amino epoxyether (I) previously reported, II gave a facile reaction with acids. The reported methods of synthesis of l-methyl-4-piperidyl phenyl ketone are evaluated, and an improved procedure is described.