Preparation and some properties of dimeric rabbit IgG antibody

Moţa, Gabriela; Sjöquist, John; Gheţie, Victor

doi:10.1016/0161-5890(84)90049-x

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…A single injection of Bordetella pertussis adjuvant plus antigen sensitised rats to challenge with the specific antigen which resulted in fatal shock, mast cell damage and histamine release [3]; further work indicated this effect was IgE-mediated [4]. The adjuvants B. pertussis, aluminium hydroxide or Freund's complete or incomplete adjuvant elicited equal responses in rats; however, th'e effect was dependent on antigen dosage [5].…”

Section: Introductionmentioning

confidence: 99%

Adjuvanted oral vaccines should not induce allergic responses to dietary antigens

Stewart-Tull¹

1992

FEMS Microbiology Letters

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Oral vaccines may contain adjuvants which might elicit allergies against dietary proteins. Four antigens were used to measure such an effect--ovalbumin, soya bean protein, lactalbumin and gluten. Neither guinea pigs nor mice showed IgE responses after oral administration of adjuvanted vaccines containing lactalbumin and gluten. No IgE responses were detected in mice with any of these antigens after oral immunization, but, in the guinea pig, nine out of 18 animals reacted to either ovalbumin or soya bean protein and none reacted to lactalbumin and gluten. It is concluded that the risk of allergy induction against normal dietary proteins is low but such tests should be applied to potential adjuvanted oral vaccines to measure any possible contraindication, especially with atopic individuals.

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Section: Introductionmentioning

confidence: 99%