Preparation and standardization of a herbal agent for the therapeutic management of asthma

Emeje, Martins; Izuka, Amaka; Isimi, Christianah; Ofoefule, S. I.; Kunle, Olobayo O.

doi:10.3109/10837450903584910

Cited by 10 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is because it would reduce cases of non-completion of therapy for economic reasons. In addition, resistance to multicomponent preparations, as is seen in herbal medicines, develops less rapidly [9]. Although more than 80 percent of the people in both the underdeveloped and the developed countries depend on herbal medicines for their medical needs, the major problem with herbal medicines in such countries still remains their poor and sometimes unhealthy presentation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial evaluation of Acacia nilotica Lam (Mimosaceae) seed extract in dermatological preparations

Aremu¹,

Olayemi²,

Ajala³

et al. 2020

jrp

View full text Add to dashboard Cite

The plant Acacia nilotica Lam (Mimosaceae) has received a lot of recognition because of its ethno-medicinal claims, some of which have been justified by scientific studies. Various forms of its presentation like the liquor concentrates (decoction) and powders are used traditionally, however, none of these have been standardized to assure efficacy, safety, stability and appropriate dose delivery. The intention of this present work was to develop an antibacterial dermatological dosage formulation that will serve as a remedy for the treatment of skin diseases. The powdered seeds were macerated in methanol for 48 h and the resultant extract was formulated using Aqueous cream BP in which parabens was substituted for chlorocresol as preservative, while lipophilic ointment base, shea butter, was used at concentrations of 5.0, 7.5 and 10.0 % w/w respectively. The formulations were evaluated physico-chemically and subsequently tested against selected organisms such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, Streptococcus pyrogens and Salmonella typhi which are commonly implicated in skin infections. Ciprofloxacin and commercially available Neomycin cream were used as reference compounds. The results showed that, all the preparations especially the ointment containing shea butter gave favourable physico-chemical characteristics and at 10.0 % w/w concentration, exhibited significant antibacterial activity (p<0.05) against the microorganisms tested with activity against Staphylococcus aureus being the highest followed by Pseudomonas aeruginosa> Streptococcus pneumonia> Klebsiella pneumonia= Escherichia coli= Salmonella typhi. Therefore showing potential for development as a standardized dosage form for the treatment of skin infections where the interrogated organisms are implicated.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Standardization of herbal medicines therefore, should be a major interest for researchers especially in Africa. A major aspect of this standardization process is the development of suitable dosage forms for these herbal medicines [9]. The plant, Acacia nilotica is an evergreen, single stemmed plant of the family; mimosaceae.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial evaluation of Acacia nilotica Lam (Mimosaceae) seed extract in dermatological preparations

Aremu¹,

Olayemi²,

Ajala³

et al. 2020

jrp

View full text Add to dashboard Cite

show abstract

“…The bulk, tapped density, compressibility and angle of repose were determined using standard methods (11). Triplicate determinations for each parameter are reported.…”

Section: Preparation Of Theophylline Granules and Compressed Matricesmentioning

confidence: 99%

Eudraginated polymer blends: A potential oral controlled drug delivery system for theophylline

Emeje¹,

John-Africa²,

Isimi³

et al. 2012

Acta Pharmaceutica

Self Cite

View full text Add to dashboard Cite

Sustained release (SR) dosage forms enable prolonged and continuous deposition of the drug in the gastrointestinal (GI) tract and improve the bioavailability of medications characterized by a narrow absorption window. In this study, a new strategy is proposed for the development of SR dosage forms for theophylline (TPH). Design of the delivery system was based on a sustained release formulation, with a modified coating technique and swelling features aimed to extend the release time of the drug. Different polymers, such as Carbopol 71G (CP), sodium carboxymethylcellulose (SCMC), ethylcellulose (EC) and their combinations were tried. Prepared matrix tablets were coated with a 5 % (m/m) dispersion of Eudragit (EUD) in order to get the desired sustained release profile over a period of 24 h. Various formulations were evaluated for micromeritic properties, drug concentration and in vitro drug release. It was found that the in vitro drug release rate decreased with increasing the amount of polymer. Coating with EUD resulted in a significant lag phase in the first two hours of dissolution in the acidic pH of simulated gastric fluid (SGF) due to decreased water uptake, and hence decreased driving force for drug release. Release became faster in the alkaline pH of simulated intestinal fluid (SIF) owing to increased solubility of both the coating and matrixing agents. The optimized formulation was subjected to in vivo studies in rabbits and the pharmacokinetic parameters of developed formulations were compared with the commercial (Asmanyl ® ) formulation. Asmanyl ® tablets showed faster absorption (t max 4.0 h) compared to the TPH formulation showing a t max value of 8.0 h. The C max and AUC values of TPH formulation were significantly (p < 0.05) higher than those for Asmanyl ® , revealing relative bioavailability of about 136.93 %. Our study demonstrated the potential usefulness of eudraginated polymers for the oral delivery of the sparingly soluble drug theophylline.

show abstract

“…leiocarpus is suitable for use in the therapeutic management of asthma, and has been developed to single tablet dosage form (Emeje et al, 2011). It possesses wound healing activity in a dose-dependent manner and provides a scientific rationale for the traditional use of it in the management of wounds .…”

Section: Introductionmentioning

confidence: 99%

Constituents of leaf, stem bark and root volatile oils of <i>Anogeissus leiocarpus</i> DC. Guill. & Perr.

Moronkola¹,

Kunle²

2015

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

We report volatile compounds in Anogeissus leiocarpus, which is scarce in literature. Here in Nigeria leaf, stem bark and root essential oils were obtained by hydro-distillation using Clevenger-type apparatus, analyzed by GC and GC-MS. 88% leaf oil comprised of eleven compounds, with abundance of z-9-octadecenoic acid (29.0), n-hexadecanoic acid (21.4), n-octadecanoic acid (12.7), methyl-7E-7-octadecenoate (8.5), and methylhexadecanoate (5.4). Thirteen compounds amount to 80% of the stem bark oil, its significant compounds being z-9-octadecenoic acid (22.8), n-hexadecanoic acid (20.8), methyl-9z-octadecenoate (12.4), methylhexadecanoate (7.8) and eicosane (4.1). Fourteen compounds make-up 91% of root oil, dominated by methyl-7E-7-octadecenoate (18.1), n-hexadecanoic acid (17.6), methyl linoleate (16.2), z-9-octadecenoic acid (15.7) and methylhexadecanoate (14.2). Leaf, stem bark and root oils are characterized by the following classes of compounds respectively (%): fatty acids [65.8, 43.6, 36.7]; esters [17.9, 20.2, 49.9]; hydrocarbons [3.2, 15.7, 1.7]; leaf and root oils contain terpenoids [1.1, 1.1]; dl-arabinose (sugar) is in stem bark oil. Methylhexadecanoate and hexadecanoic acid are common to the three oils. They can serve as chemotaxonomic markers characteristic for this species. Compositions of Anogeissus leiocarpus three oils vary, are unique and of different chemo-types. This report is first of its kind in literature for 'axlewood' plant.

show abstract

Preparation and standardization of a herbal agent for the therapeutic management of asthma

Cited by 10 publications

References 13 publications

Antibacterial evaluation of Acacia nilotica Lam (Mimosaceae) seed extract in dermatological preparations

Antibacterial evaluation of Acacia nilotica Lam (Mimosaceae) seed extract in dermatological preparations

Eudraginated polymer blends: A potential oral controlled drug delivery system for theophylline

Constituents of leaf, stem bark and root volatile oils of <i>Anogeissus leiocarpus</i> DC. Guill. & Perr.

Contact Info

Product

Resources

About