Preparation and use of nanogels as carriers of drugs

Li, Cuixia; Obireddy, Sreekanth Reddy; Lai, Wing‐Fu

doi:10.1080/10717544.2021.1955042

Cited by 73 publications

(49 citation statements)

References 101 publications

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“…Moreover, it has a tendency to retain a large quantity of aqueous fluid without dissolving onto them and is widely explored in drug delivery and biomedical engineering. The polymeric network in the gel system plays a significant role in determining physicochemical properties and hydrophilicity, and controlling particle size; small pores in the polymeric network enables the accommodation of small molecules [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Development, Characterization, and Evaluation of α-Mangostin-Loaded Polymeric Nanoparticle Gel for Topical Therapy in Skin Cancer

Alhakamy

Neamatallah

et al. 2021

Gels

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The aim of this study was to prepare and evaluate α-mangostin-loaded polymeric nanoparticle gel (α-MNG-PLGA) formulation to enhance α-mangostin delivery in an epidermal carcinoma. The poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were developed using the emulsion–diffusion–evaporation technique with a 3-level 3-factor Box–Behnken design. The NPs were characterized and evaluated for particle size distribution, zeta potential (mV), drug release, and skin permeation. The formulated PLGA NPs were converted into a preformed carbopol gel base and were further evaluated for texture analysis, the cytotoxic effect of PLGA NPs against B16-F10 melanoma cells, and in vitro radical scavenging activity. The nanoscale particles were spherical, consistent, and average in size (168.06 ± 17.02 nm), with an entrapment efficiency (EE) of 84.26 ± 8.23% and a zeta potential of −25.3 ± 7.1 mV. Their drug release percentages in phosphate-buffered solution (PBS) at pH 7.4 and pH 6.5 were 87.07 ± 6.95% and 89.50 ± 9.50%, respectively. The release of α-MNG from NPs in vitro demonstrated that the biphasic release system, namely, immediate release in the initial phase, was accompanied by sustained drug release. The texture study of the developed α-MNG-PLGA NPs gel revealed its characteristics, including viscosity, hardness, consistency, and cohesiveness. The drug flux from α-MNG-PLGA NPs gel and α-MNG gel was 79.32 ± 7.91 and 16.88 ± 7.18 µg/cm2/h in 24 h, respectively. The confocal study showed that α-MNG-PLGA NPs penetrated up to 230.02 µm deep into the skin layer compared to 15.21 µm by dye solution. MTT assay and radical scavenging potential indicated that α-MNG-PLGA NPs gel had a significant cytotoxic effect and antioxidant effect compared to α-MNG gel (p < 0.05). Thus, using the developed α-MNG-PLGA in treating skin cancer could be a promising approach.

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Section: Introductionmentioning

confidence: 99%

Development, Characterization, and Evaluation of α-Mangostin-Loaded Polymeric Nanoparticle Gel for Topical Therapy in Skin Cancer

Alhakamy

Neamatallah

et al. 2021

Gels

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“…As NPs possess an ability to load and deliver an amazing spectrum of drugs to almost any organ of the body, delivering focused, regulated, as well as prolonged therapeutic effects, they have become an important subject of drug delivery studies [ 12 ] as shown in Table 1 . Examples of nanogels are reported for drug delivery applications including both hydrophobic and hydrophilic agents, and even oligodeoxynucleotides [ 13 ].…”

Section: Nanocarrier As a Drug Delivery Mechanismmentioning

confidence: 99%

“…Nanogels are employed for both local and systemic drug action because of their natural ability to swell due to chemical alteration, allowing the drug to be released in the desired dosage form [ 13 ]. Nanogels can be used to make dermal patches, biosensors, and ionic drug delivery.…”

Section: Nanotechnological Approachmentioning

confidence: 99%

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

Sindhu

Gupta

Wadhera

et al. 2022

Gels

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This study examined the most recent advancements in nanogel production and drug delivery. Phytochemistry is a discipline of chemistry that studies herbal compounds. Herbal substances have aided in the development of innovative remedies for a wide range of illnesses. Several of these compounds are forbidden from being used in medications due to broad medical characteristics and pharmacokinetics. A variety of new technical approaches have been investigated to ameliorate herbal discoveries in the pharmaceutical sector. The article focuses on the historical data for herb-related nanogels that are used to treat a variety of disorders with great patient compliance, delivery rate, and efficacy. Stimulus-responsive nanogels such as temperature responsive and pH-responsive systems are also discussed. Nanogel formulations, which have been hailed as promising targets for drug delivery systems, have the ability to alter the profile of a drug, genotype, protein, peptide, oligosaccharide, or immunogenic substance, as well as its ability to cross biological barriers, biodistribution, and pharmacokinetics, improving efficacy, safety, and patient cooperation.

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“…Various fabrication methods for these nanoparticles have been developed to match the used material to properties of the encapsulated cargo and its intended target. Extensive reviews summarizing these methods are available in the literature [29][30][31][32][33]. Nanoparticles, whether lipid or polymeric, typically show a particle size range of 1 to 100 nm [34], though some use the term for larger particles, up to 500 nm.…”

Section: Nanoparticlesmentioning

confidence: 99%

Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections

et al. 2021

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Bacterial infections constitute a threat to public health as antibiotics are becoming less effective due to the emergence of antimicrobial resistant strains and biofilm and persister formation. Antimicrobial peptides (AMPs) are considered excellent alternatives to antibiotics; however, they suffer from limitations related to their peptidic nature and possible toxicity. The present review critically evaluates the chemical characteristics and antibacterial effects of lipid and polymeric AMP delivery systems and coatings that offer the promise of enhancing the efficacy of AMPs, reducing their limitations and prolonging their half-life. Unfortunately, the antibacterial activities of these systems and coatings have mainly been evaluated in vitro against planktonic bacteria in less biologically relevant conditions, with only some studies focusing on the antibiofilm activities of the formulated AMPs and on the antibacterial effects in animal models. Further improvements of lipid and polymeric AMP delivery systems and coatings may involve the functionalization of these systems to better target the infections and an analysis of the antibacterial activities in biologically relevant environments. Based on the available data we proposed which polymeric AMP delivery system or coatings could be profitable for the treatment of the different hard-to-treat infections, such as bloodstream infections and catheter- or implant-related infections.

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Preparation and use of nanogels as carriers of drugs

Cited by 73 publications

References 101 publications

Development, Characterization, and Evaluation of α-Mangostin-Loaded Polymeric Nanoparticle Gel for Topical Therapy in Skin Cancer

Development, Characterization, and Evaluation of α-Mangostin-Loaded Polymeric Nanoparticle Gel for Topical Therapy in Skin Cancer

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections

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