Preparation and Utility of Platelet-Rich Plasma (PRP) for Facial Aging: A Comprehensive Review

Bajaj, Shirin; Orbuch, David; Wang, Jordan V; Geronemus, Roy G.

doi:10.1007/s12325-022-02239-6

Cited by 8 publications

(9 citation statements)

References 85 publications

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“…To prepare PRP, the collected blood was separated according to the methods reported in the literature [ 27 , 28 ], MoSe 2 was prepared according to a previous study [ 29 ]. To prepare the hydrogels, 0.1 g of CMCS powder was first dissolved in 2 ml of deionized water in a water bath at 50 ◦ C and stirred to form a homogeneous CMCS solution, which was then transferred to a magnetic stirrer for homogenous stirring.…”

Section: Methodsmentioning

confidence: 99%

Molybdesum selenide-based platelet-rich plasma containing carboxymethyl chitosan/polyvinyl pyrrolidone composite antioxidant hydrogels dressing promotes the wound healing

Zheng,

Ouyang,

Fan

et al. 2024

J Nanobiotechnol

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Excess free radicals at the wound site can cause an inflammatory response, which is not conducive to wound healing. Hydrogels with antioxidant properties can prevent inflammatory storms by scavenging free radicals from the wound site and inhibiting the release of inflammatory factors. In this study, we prepared the carboxymethyl chitosan (CMCS)/polyvinyl pyrrolidone (PVP)/Molybdenum (IV) Selenide (MoSe2), and platelet-rich plasma (PRP) (CMCS/PVP/MoSe2/PRP) hydrogels for accelerating the repair of wounds. In the hydrogels, the MoSe2 can scavenge various free radicals to reduce oxidative stress at the site of inflammation, endowed the hydrogels with antioxidant properties. Interestingly, growth factors released by PRP assisted the tissue repair by promoting the formation of new capillaries. CMCS as a backbone not only showed good biocompatibility and biodegradability but also played a significant role in maintaining the sustained release of growth factors. In addition, incorporating PVP enhanced the tissue adhesion and mechanical properties. The multifunctional composite antioxidant hydrogels have good swelling properties and biodegradability, which is completely degraded within 28 days. Thus, the antioxidant CMCS/PVP/MoSe2/PRP hydrogels provide a new idea for designing ideal multifunctional wound dressings.

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Section: Methodsmentioning

confidence: 99%

Molybdesum selenide-based platelet-rich plasma containing carboxymethyl chitosan/polyvinyl pyrrolidone composite antioxidant hydrogels dressing promotes the wound healing

Zheng,

Ouyang,

Fan

et al. 2024

J Nanobiotechnol

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“…The utilization of platelet concentrates has garnered considerable interest, yet its clinical efficacy is controversial primarily due to the inherent variability in composition observed among individual patients. (Bajaj et al, 2022;Kerscher et al, 2022). To address this issue, ongoing efforts aim to define optimized protocols for using PRP in skin treatments, ensuring more reliable and predictable outcomes (Chahla et al, 2017;Bansal et al, 2021).…”

Section: Mechanism Of Action Benefitsmentioning

confidence: 99%

Approaches in line with human physiology to prevent skin aging

Karimi

2023

Front. Physiol.

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Skin aging is a complex process that is influenced by intrinsic and extrinsic factors that impact the skin’s protective functions and overall health. As the body’s outermost layer, the skin plays a critical role in defending it against external threats, regulating body temperature, providing tactile sensation, and synthesizing vitamin D for bone health, immune function, and body homeostasis. However, as individuals age, the skin undergoes structural and functional changes, leading to impairments in these essential functions. In contemporary society, there is an increasing recognition of skin health as a significant indicator of overall wellbeing, resulting in a growing demand for anti-aging products and treatments. However, these products often have limitations in terms of safety, effective skin penetration, and potential systemic complications. To address these concerns, researchers are now focusing on approaches that are safer and better aligned with physiology of the skin. These approaches include adopting a proper diet and maintaining healthy lifestyle habits, the development of topical treatments that synchronize with the skin’s circadian rhythm, utilizing endogenous antioxidant molecules, such as melatonin and natural products like polyphenols. Moreover, exploring alternative compounds for sun protection, such as natural ultraviolet (UV)-absorbing compounds, can offer safer options for shielding the skin from harmful radiation. Researchers are currently exploring the potential of adipose-derived stem cells, cell-free blood cell secretome (BCS) and other endogenous compounds for maintaining skin health. These approaches are more secure and more effective alternatives which are in line with human physiology to tackle skin aging. By emphasizing these innovative strategies, it is possible to develop effective treatments that not only slow down the skin aging process but also align better with the natural physiology of the skin. This review will focus on recent research in this field, highlighting the potential of these treatments as being safer and more in line with the skin’s physiology in order to combat the signs of aging.

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“…PDBs are classified based on their preparation protocol and whether or not an anticoagulant is added during their preparation [ 29 ]. The first generation of platelet concentrates is termed platelet-rich plasma (PRP) which includes the addition of an anticoagulant to the blood sample which prevents clotting during the centrifugation cycle [ 34 ]. PRP is the most widely studied platelet concentrate in regenerative medicine with many investigations demonstrating its benefit in cardiac surgery [ 35 ], osteoarthritis [ 36 ], osteoporosis [ 37 ], dermal rejuvenation [ 34 ], and dentistry [ 38 , 39 ].…”

Section: Pdbs Used In Clinical Therapiesmentioning

confidence: 99%

“…The first generation of platelet concentrates is termed platelet-rich plasma (PRP) which includes the addition of an anticoagulant to the blood sample which prevents clotting during the centrifugation cycle [ 34 ]. PRP is the most widely studied platelet concentrate in regenerative medicine with many investigations demonstrating its benefit in cardiac surgery [ 35 ], osteoarthritis [ 36 ], osteoporosis [ 37 ], dermal rejuvenation [ 34 ], and dentistry [ 38 , 39 ]. It possesses antimicrobial [ 40 ], anti-inflammatory [ 41 ], and regenerative properties [ 42 ].…”

Section: Pdbs Used In Clinical Therapiesmentioning

confidence: 99%

The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence

Amiri,

Farshidfar,

Miron

et al. 2023

International Journal of Biomaterials

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Osteoporosis is a chronic multifactorial condition that affects the skeletal system, leading to the deterioration of bone microstructure and an increased risk of bone fracture. Platelet-derived biomaterials (PDBs), so-called platelet concentrates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have shown potential for improving bone healing by addressing microstructural impairment. While the administration of platelet concentrates has yielded positive results in bone regeneration, the optimal method for its administration in the clinical setting is still debatable. This comprehensive review aims to explore the systemic and local use of PRP/PRF for treating various bone defects and acute fractures in patients with osteoporosis. Furthermore, combining PRP/PRF with stem cells or osteoinductive and osteoconductive biomaterials has shown promise in restoring bone microstructural properties, treating bony defects, and improving implant osseointegration in osteoporotic animal models. Here, reviewing the results of in vitro and in vivo studies, this comprehensive evaluation provides a detailed mechanism for how platelet concentrates may support the healing process of osteoporotic bone fractures.

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Preparation and Utility of Platelet-Rich Plasma (PRP) for Facial Aging: A Comprehensive Review

Cited by 8 publications

References 85 publications

Molybdesum selenide-based platelet-rich plasma containing carboxymethyl chitosan/polyvinyl pyrrolidone composite antioxidant hydrogels dressing promotes the wound healing

Molybdesum selenide-based platelet-rich plasma containing carboxymethyl chitosan/polyvinyl pyrrolidone composite antioxidant hydrogels dressing promotes the wound healing

Approaches in line with human physiology to prevent skin aging

The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence

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