Preparation , Characterisation and Biological activities of Some metal Complexes of [N[2-(4,5-diphenyl-3-thion-1,2,4-triazole)methyl]diphenyl amino]

Preparation, Structural and Antimicrobial Studies of a New Bimetallic Complexes Involving a New Schiff and Mannich Bases

“…Thiadiazole derivatives, especially those of 2-thio-1,3,4-thiadiazole-5-substituted, were reported to have different interesting biological activities (1)(2)(3) . In continuation of previous work (4) , the synthesis and characterization of the mannich base derived from 5-phynyl-2-thione-1,3,4-thiadiazole and diphynyl amine was described along with a number of its transition metal complexes and were found that a synergic effect in the bioactivity took place upon complexation and different structural behavior was reported depending on the type of the metal besides the ligand structure. These results promote us to continue our work, and we here synthesis a new mannich base derivative of this hetrocyclic ring with involving imino group,to be used as a ligand to form a new type of bimetallic complexes toward some transition metal ions {V(IV), Mn(II), Fe(III), Pd(II), Au(III) and Pt(IV)} to investigate the introduction the imino moiety in the structure of mannich base derivative of mercaptothiazole ring and coordination behaviour, then compare the biological activity of the ligang and their complexes with the main ring structure.…”

“…(A 1 ) was prepared as described in our previous work (4)(5)(6)(7) , starting from thio semicarbazid to prepare the -2-thione-5amino-1,3,4-thiadiazole, which was then reacted with pyrazol in the presence of formaline to get the final product [ Scheme (1) :The following scheme illustrate the structures of (A 1 ),(A 2 ) and (A 3 ).…”

“…The absorbance (As and Am) of the solution were messured at (λ max ) of maximum absorption. The stability constant (K), and the molar absorptivity (ε max ) have been calculated, were listed in Table (4).…”