Preparation, characterization and antibacterial activity of a novel soluble polymer derived from xanthone and O-carboxymethyl-N, N, N-trimethyl chitosan

Wang, Hong; Zhang, Yisheng; Xue, Wenman; Zhang, Xinyu; Jia, Xiaoli; Xue, Tianren; Guo, Ruijie; Niu, Baolong; Yan, Hong

doi:10.1016/j.ijbiomac.2020.07.147

Cited by 11 publications

(10 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Introducing carboxyl groups into CS can significantly improve its solubility and provide a negative charge surface to avoid the aggregation of nanoparticles and prolong blood circulation time. 17,18 Therefore, carboxymethyl chitosan (CMCS) is an ideal carrier material for preparing pH-responsive nanogels.…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan (CS) possesses good biocompatibility, pH-dependent charge reversal characteristics, and low immunogenicity and is widely used in the delivery of anticancer or genetic drugs, biosensing, and tissue engineering. , However, the poor solubility characteristics of CS can only be dissolved in dilute acid aqueous solution limits its wide application as a drug carrier to a certain extent. Introducing carboxyl groups into CS can significantly improve its solubility and provide a negative charge surface to avoid the aggregation of nanoparticles and prolong blood circulation time. , Therefore, carboxymethyl chitosan (CMCS) is an ideal carrier material for preparing pH-responsive nanogels.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Angiopep-2-Modified Carboxymethyl Chitosan-Based pH/Reduction Dual-Stimuli-Responsive Nanogels for Enhanced Targeting Glioblastoma

Song

et al. 2021

Biomacromolecules

View full text Add to dashboard Cite

Glioblastoma (GBM) is a fatal brain tumor with poor prognosis. Blood–brain barrier (BBB) prevents the effective delivery of chemotherapeutic agents to GBM. Herein, we developed a pH/reduction-sensitive carboxymethyl chitosan nanogel (CMCSN) modified by targeting peptide angiopep-2 (ANG) and loaded with doxorubicin (DOX). The multifunctional nanogel (DOX-ANG-CMCSN) exhibited good pH and reduction sensitivity, ideal stability, and biocompatibility. Its hydrodynamic diameter was 190 nm, drug loading was 12.7%, and the cumulative release rate of 24 h was 82.3% under the simulated tumor microenvironment. More importantly, the modification of ANG significantly enhanced BBB penetration and tumor targeting ability both in vivo and in vitro. DOX-ANG-CMCSN achieved 2–3-fold higher uptake and an enhanced antitumor activity compared with nontargeted DOX-CMCSN. Therefore, the targeted nanogels with the pH/reduction dual-stimuli response may provide a promising platform for GBM-targeted chemotherapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Angiopep-2-Modified Carboxymethyl Chitosan-Based pH/Reduction Dual-Stimuli-Responsive Nanogels for Enhanced Targeting Glioblastoma

Song

et al. 2021

Biomacromolecules

View full text Add to dashboard Cite

show abstract

“…Studies have shown that gram-negative bacteria are more sensitive to chitosan because the surface of gram-negative bacteria has a higher negative charge value [ 189 ]. However, in other studies, chitosan showed higher antibacterial activity against gram-positive bacteria [ 120 , 190 , 191 ]. This is because their cell walls are composed of a thick layer of peptidoglycan and phosphoteichoic acid, which is unique to gram-positive bacteria.…”

Section: Antibacterial Mechanismsmentioning

confidence: 83%

“…To avoid the use of toxic or irritating solvents such as HFIP, CF, TFA, and acetic acid, chitosan can be modified and made water-soluble. The current modification methods involve the preparation of carboxylated chitosan and chitosan salt [ 117 , 118 , 119 , 120 ]. This includes carboxymethyl chitosan, carboxyethyl chitosan, quaternized chitosan, etc.…”

Section: Antibacterial Materialsmentioning

confidence: 99%

Application of Electrospinning in Antibacterial Field

Chen

et al. 2021

Nanomaterials

View full text Add to dashboard Cite

In recent years, electrospun nanofibers have attracted extensive attention due to their large specific surface area, high porosity, and controllable shape. Among the many applications of electrospinning, electrospun nanofibers used in fields such as tissue engineering, food packaging, and air purification often require some antibacterial properties. This paper expounds the development potential of electrospinning in the antibacterial field from four aspects: fiber morphology, antibacterial materials, antibacterial mechanism, and application fields. The effects of fiber morphology and antibacterial materials on the antibacterial activity and characteristics are first presented, then followed by a discussion of the antibacterial mechanisms and influencing factors of these materials. Typical application examples of antibacterial nanofibers are presented, which show the good prospects of electrospinning in the antibacterial field.

show abstract

“…30,128 Oxanthonyl-chitosan (Figure 12, compound 3) is an example of a quaternary derivative of chitosan with promising antibacterial activity. 129 This compound compared to its starting materials showed a better solubility in water and a better antibacterial activity, being these improvements associated with the positive charges of the quaternary ammonium groups and with the multi-hydroxy planar benzene structure. 129 In addition, other studies have shown that chitosan has antifungal activity against Candida strains, which is responsible for superficial mycoses, including vulvovaginal candidiasis.…”

Section: Biological Activitiesmentioning

confidence: 95%

Molecular modifications, biological activities, and applications of chitosan and derivatives: A recent update

2022

View full text Add to dashboard Cite

Polysaccharides arouse great interest due to their structure and unique properties, such as biocompatibility, biodegradability, and absence of toxicity. Polysaccharides from marine sources are particularly useful due to the wide variety of applications and biological activities. Chitosan, a deacetylated derivative of chitin, is an example of an interesting bioactive marine-derived polysaccharide. Moreover, a wide variety of chemical modifications and conjugation of chitosan with other bioactive molecules are responsible for improvements in physicochemical properties and biological activities, expanding the range of applications. An overview of the synthetic approaches for preparing chitosan, chitosan derivatives, and conjugates is described and discussed. A recent update of the biological activities and applications in different research fields, mainly focused on the last 5 years, is presented, highlighting current trends.

show abstract

Preparation, characterization and antibacterial activity of a novel soluble polymer derived from xanthone and O-carboxymethyl-N, N, N-trimethyl chitosan

Cited by 11 publications

References 46 publications

Angiopep-2-Modified Carboxymethyl Chitosan-Based pH/Reduction Dual-Stimuli-Responsive Nanogels for Enhanced Targeting Glioblastoma

Angiopep-2-Modified Carboxymethyl Chitosan-Based pH/Reduction Dual-Stimuli-Responsive Nanogels for Enhanced Targeting Glioblastoma

Application of Electrospinning in Antibacterial Field

Molecular modifications, biological activities, and applications of chitosan and derivatives: A recent update

Contact Info

Product

Resources

About