Preparation, characterization and antioxidant activities of polymannuronic acid phosphate, H-phosphonate and sulfate

Li, Quancai; Li, Chunxia; Yang, Cheng; Liu, Chenchang; Yu, Guangli; Guan, Huashi

doi:10.1016/j.ijbiomac.2013.09.012

Cited by 25 publications

(9 citation statements)

References 40 publications

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“…1 B). Furthermore, it could be inferred from the molecular weights of PMPs that higher molecular weights tend to yield monophosphate such as PMP3, which was consistent with our previous report [ 51 ]. Meanwhile, we also found that PM at relatively low molecular weights would yield bisphosphonates after phosphorylation modifications, such as PMP1.…”

Section: Resultssupporting

confidence: 92%

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Inhibitory activities of alginate phosphate and sulfate derivatives against SARS-CoV-2 in vitro

Yang

Wang

et al. 2023

International Journal of Biological Macromolecules

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Section: Resultssupporting

confidence: 92%

“…In the 1 H NMR spectrum, a new signal peak at 4.20 ppm appeared. Based on the previous experimental results, we speculated that it was due to the shift of the H 3 signal to the low-field caused by C 3 -OH substitution with phosphate group, and the proton hydrogen was marked as H 3 ' [ 51 ] ( Fig. 1 C).…”

Section: Resultsmentioning

confidence: 99%

Inhibitory activities of alginate phosphate and sulfate derivatives against SARS-CoV-2 in vitro

Yang

Wang

et al. 2023

International Journal of Biological Macromolecules

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“…With some modifications, the molecular weight of SA was measured according to the method described by Li et al ( 20 ). Accurately weighed SA-1, SA-2, and SA-3 were dissolved in 0.1 mol/L NaNO 3 solution containing 0.02% NaN 3 to obtain 4 mg/mL SA-1, SA-2, and SA-3 solution.…”

Section: Methodsmentioning

confidence: 99%

Effects of M/G Ratios of Sodium Alginate on Physicochemical Stability and Calcium Release Behavior of Pickering Emulsion Stabilized by Calcium Carbonate

et al. 2022

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The gel properties of sodium alginate (SA) have been revealed to be strongly correlated with its ratio of D-mannuronate to L-guluronate (M/G ratio). Herein, we focused on SA with different M/G ratios to conduct an in-depth study on the effect of the M/G ratio difference on physicochemical stability and calcium release behavior of the Pickering emulsion stabilized by calcium carbonate (CaCO3). The oil phase was added to the aqueous phase, prepared by SA with different M/G ratios (2.23, 0.89, and 0.56) and CaCO3, for one-step shearing to obtain the E1, E2, and E3 emulsions, respectively. The results of the particle size, microstructure, long-term stability, rheological, and microrheological properties of the emulsions showed that the E3 emulsion, prepared by SA with a smaller M/G ratio, had a smaller particle size and has remained in a flow condition during the long-term storage, while the E1 and E2 emulsions had a gelation behavior and a stronger viscoelasticity. Moreover, the emulsion, as a liquid calcium supplement, is not only convenient for oral intake while meeting the calcium needs of the body, but also controls the release of Ca2+. The calcium release of the emulsions in a simulated gastric environment demonstrated that the calcium release ratio increased with the decrease of SA concentration, with the increase of M/G ratio, and with the decrease of oil phase volume.

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“…LPMP was synthesized in our laboratory by the phosphoric acid urine method [ 35 , 62 ]. Moreover, the FITC-labeled LPMP was prepared with slight modifications according to the published literature [ 63 ].…”

Section: Methodsmentioning

confidence: 99%

A Novel PTP1B Inhibitor-Phosphate of Polymannuronic Acid Ameliorates Insulin Resistance by Regulating IRS-1/Akt Signaling

Zhang

Yang

et al. 2021

IJMS

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Protein tyrosine phosphatase 1B (PTP1B) is a critical negative modulator of insulin signaling and has attracted considerable attention in treating type 2 diabetes mellitus (T2DM). Low-molecular-weight polymannuronic acid phosphate (LPMP) was found to be a selective PTP1B inhibitor with an IC50 of 1.02 ± 0.17 μM. Cellular glucose consumption was significantly elevated in insulin-resistant HepG2 cells after LPMP treatment. LPMP could alleviate oxidative stress and endoplasmic reticulum stress, which are associated with the development of insulin resistance. Western blot and polymerase chain reaction (PCR) analysis demonstrated that LPMP could enhance insulin sensitivity through the PTP1B/IRS/Akt transduction pathway. Furthermore, animal study confirmed that LPMP could decrease blood glucose, alleviate insulin resistance, and exert hepatoprotective effects in diabetic mice. Taken together, LPMP can effectively inhibit insulin resistance and has high potential as an anti-diabetic drug candidate to be further developed.

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Preparation, characterization and antioxidant activities of polymannuronic acid phosphate, H-phosphonate and sulfate

Cited by 25 publications

References 40 publications

Inhibitory activities of alginate phosphate and sulfate derivatives against SARS-CoV-2 in vitro

Inhibitory activities of alginate phosphate and sulfate derivatives against SARS-CoV-2 in vitro

Effects of M/G Ratios of Sodium Alginate on Physicochemical Stability and Calcium Release Behavior of Pickering Emulsion Stabilized by Calcium Carbonate

A Novel PTP1B Inhibitor-Phosphate of Polymannuronic Acid Ameliorates Insulin Resistance by Regulating IRS-1/Akt Signaling

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