Preparation, characterization and application of functional polyethersulfone membranes blended with poly (acrylic acid) gels

Wei, Qiang; Li, Jie; Qian, Bingnan; Fang, Baohong; Zhao, Changsheng

doi:10.1016/j.memsci.2009.03.055

Cited by 82 publications

(41 citation statements)

References 33 publications

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“…Although many mechanisms have been postulated for emulsion formation, the effects of agitator speed on the properties of an emulsion have not yet been clarified. 39,40) However, in one of the study, it was reported that the particle size of emulsions decreased as the agitator speed increased, which was in close agreement with the present results. 41) Thus, 350 rpm was selected as the optimal agitator speed for preparation of DOX-loaded W/O/W microemulsion, because it gave relatively uniform emulsion droplets with a narrow particle size distribution.…”

Section: Effect Of Process Parameters On Mean Droplet Size and Distrisupporting

confidence: 92%

Fabrication, Characterization and Pharmacokinetic Evaluation of Doxorubicin-Loaded Water-in-Oil-in-Water Microemulsions Using a Membrane Emulsification Technique

Pradhan

Kim

Jeong

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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Doxorubicin (DOX)-loaded water-in-oil-in-water (W/O/W) microemulsions were produced using a shirasu-porous-glass (SPG) membrane emulsification technique. Soybean oil was used as the oil phase; polyglycerol polyricinoleate (PGPR) or tetraglycerol polyricinoleate (TGPR) was used as the surfactant to stabilize the feed W/O emulsions, while Tween 20 was used in the external water phase to stabilize oil droplets containing water droplets. Increasing the feed pressure from 50 to 90 kPa increased the particle size of W/O/W emulsions, whereas it was decreased by increasing the agitator speed. The smallest particle sizes of multiple emulsions were obtained at the feed pressure of 50 kPa and agitator speed of 350 rpm. Under this set of conditions, the increase in the concentration of PGPR or TGPR showed a decrease in the particle size of DOX-loaded W/O/W emulsions. The optimized formulation comprising of 5% w/v PGPR and 3% w/v Tween 20 in the oil phase and external water phase, respectively, with 0.5% w/v of DOX had a particle size of 0.440 0.007 µm and polydispersity index of 0.220 0.087, which was supported by the transmission electron microscopy image. The formulations showed a sustained release profile in phosphate buffer solution (pH 7.4). The plasma concentrations of DOX after intravenous administration to rats were prolonged and gave approximately 17-fold higher area under the drug concentration-time curve (AUC) compared to free DOX solution. Thus, these results demonstrated that the SPG membrane emulsification technique could be used as a promising technique to prepare W/O/W microemulsions for delivering DOX with sustained release characteristics and better bioavailability.Key words microemulsion; shirasu-porous-glass; doxorubicin; sustained release; pharmacokinetics Over the past two decades, an increasing interest has been devoted to multiple emulsions due to their multiple compartment structure and an immense capability of encapsulating hydrophilic drug substances for sustained released characteristics. [1][2][3][4] The potential application of water-in-oil-in-water (W/O/W) multiple emulsion is not only limited to pharmaceuticals but also in the field of cosmetics and food industry. In cosmetics and pharmaceuticals, W/O/W emulsions have been used for controlled release and targeted delivery of drugs. [5][6][7][8] Food applications include the encapsulation of vitamin/minerals, 9,10) and the production of low-calorie foods. 11) W/O/W emulsions are usually created using conventional homogenization technology in a two-step procedure. 12) First, a primary water-in-oil (W/O) emulsion is prepared by homogenizing an oil phase and an aqueous phase together in the presence of a suitable oil-soluble emulsifier (low hydrophilic to lipophilic balance (HLB)<10). Second, W/O/W emulsion is prepared by homogenizing W/O emulsion with another aqueous phase in the presence of a suitable water-soluble emulsifier (high HLB>10). 1) However, the second step often results in high polydispersity or low encapsulation efficiency. Therefo...

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Section: Effect Of Process Parameters On Mean Droplet Size and Distrisupporting

confidence: 92%

Fabrication, Characterization and Pharmacokinetic Evaluation of Doxorubicin-Loaded Water-in-Oil-in-Water Microemulsions Using a Membrane Emulsification Technique

Pradhan

Kim

Jeong

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…A comparison of Figure 2 a with Figure 2 b shows a partial reduction in the voidage of the former. Similar to previous research on PES/PAA blended membranes, [ 32,33 ] there is no indication of polymer-polymer phase separation. Hence it may be safely concluded that there was good interpenetration of PES and PAA polymer chains in the membrane.…”

Section: Preparation Of Ag/agcl Nanocomposite Membranesupporting

confidence: 87%

“…PAA is a polymeric additive commonly used in membrane preparation to introduce hydrophilicity and ion-exchange properties. [32][33][34][35] Since the p K a of PAA is ≈4.75 and lower than the p K a of water (7.0), the PAA carboxylic groups are nearly completely ionized in water. Hence the presence of PAA could introduce negative charge to the PES-based substrate.…”

Section: Introductionmentioning

confidence: 99%

Dual‐Functional Coating of Forward Osmosis Membranes for Hydrophilization and Antimicrobial Resistance

Qing

Zhou

et al. 2016

Adv Materials Inter

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Microbial fouling and internal concentration polarization (ICP) are factors limiting the performance of forward osmosis (FO) membranes. These limitations in flat sheet thin film composite (TFC) FO membranes are mitigated by a single Ag/AgCl nanocomposite coating in this study. The coating is prepared by first adsorbing Ag+ on the negatively charged carboxylate groups of polyacrylic acid (PAA)‐polyethersulfone (PES) blend membrane substrate (support layer). Cl− ions are introduced next to form a conformal AgCl coating in situ. Irradiation of the coating with visible light then converts it into a composite coating with nano‐Ag(n‐Ag) on the membrane substrate exterior and AgCl in the membrane substrate interior. The Ag/AgCl‐coated membranes prepared as such deliver good antimicrobial resistance concurrently with a high water flux. The antimicrobial performance can be attributed to a high loading of n‐Ag on the membrane exterior while the high water flux to the AgCl hydrophilization of the membrane interior which reduces the ICP. To the best of our knowledge, this is probably the first demonstration of a dual‐functional coating for FO TFC membranes.

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“…These limitations of PES membrane is overcome by enhancing the surface hydrophilicity of the PES using different methods [27][28][29]. A number of research studies have been reported on the hydrophilization of PES membranes [30][31][32][33][34][35][36][37][38]. In these studies, a hydrophilic additive (usually inorganic or polymeric) is often added to the casting dope to prepare hydrophilic composite PES membranes.…”

Section: Introductionmentioning

confidence: 99%

Improved Performance of CaCl 2 Incorporated Polyethersulfone Ultrafiltration Membranes

Krishnamoorthy

Velu

2016

Period. Polytech. Chem. Eng.

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Preparation, characterization and application of functional polyethersulfone membranes blended with poly (acrylic acid) gels

Cited by 82 publications

References 33 publications

Fabrication, Characterization and Pharmacokinetic Evaluation of Doxorubicin-Loaded Water-in-Oil-in-Water Microemulsions Using a Membrane Emulsification Technique

Fabrication, Characterization and Pharmacokinetic Evaluation of Doxorubicin-Loaded Water-in-Oil-in-Water Microemulsions Using a Membrane Emulsification Technique

Dual‐Functional Coating of Forward Osmosis Membranes for Hydrophilization and Antimicrobial Resistance

Improved Performance of CaCl 2 Incorporated Polyethersulfone Ultrafiltration Membranes

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