Since the discovery of graphene, its excellent optical, electrical, and mechanical properties have important application prospects in numerous fields. Herein, introducing the related application of graphene into chemical experiments is of great significance to enhance students' extracurricular knowledge and cultivate their scientific research consciousness. In this experiment, we designed a multifunctional GO/TA@β-FeOOH membrane with a multilayered structure to achieve sewage treatment. The whole experiment teaching includes the preparation, characterization, and application of a graphene oxide (GO)based membrane, which can enhance undergraduates' practical ability, increase understanding of modern scientific research methods, and inspire scientific research thinking. For the membrane preparation method, the vacuum-assisted methods, polyphenol complex cross-linking reaction, and biomimetic mineralization functionalization would increase students' theoretical knowledge of chemical reactions and processes. Meanwhile, surface structure and composition analysis of modern analytical techniques (SEM, AFM, XPS, and FT-IR) can deepen the students' understanding and application of instrumental analysis. During the performance evaluation process, the newly designed comprehensive experimental teaching not only demonstrates some cross background knowledge of environmental science, material science, separation, and chemical engineering but also provided some basic theories of interfacial wettability, membrane separation engineering for removing oil and dyes, and photo-Fenton catalytic degradation technology for the dyes, which further motivated students' interest in topics of GO-based membrane, enhanced the execution of experimental operations, and depended on their understanding of environmental pollution. Hence, we believe that this novel experimental teaching project is helpful for college students to improve their comprehensive quality, enhancing their innovation and practical ability.