Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia–zirconia stationary phase

Wang, Qing; Chen, Jie; Huang, Kun; Zhang, Xin; Xu, Liang; Shi, Zhi‐Guo

doi:10.1016/j.aca.2014.11.022

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…Thus, 1% FA-MeOH was selected as the optimal solvent composition in the following experiments. Moreover, all the phospholipids could also be completely desorbed under alkaline conditions with 1.5% ammonia (Figure S1), which conforms to adsorption–desorption conditions of the phosphate group on Lewis acidic materials reported in previous studies. − From Figure B-1,C-1, the adsorption efficiencies of different lipids on Zr 6 -BTB with and without OTf modification in the optimal solvent composition are compared. The ratios of phospholipid recovery to those of other lipids (R = phospholipids/other lipids without phosphate group, selectivity to phospholipid) were 5.2–144.9 on Zr 6 OTf-BTB, whereas the selectivity to phospholipids on Zr 6 -BTB was only 0.7–2.3.…”

Section: Resultssupporting

confidence: 85%

“…As shown in Figure A, with the increase of the formic acid concentration in the solvent, the adsorption efficiencies of phospholipids increased. In previous studies, the increased adsorption efficiencies of phospholipid with increase of solvent acidity on other Lewis acidic materials were also reported. − Moreover, besides the increase of phospholipid adsorption efficiencies, it could be found that other lipids, especially for DG and DHA, have obvious decreases in adsorption efficiencies on Zr 6 OTf-BTB with the increase of FA concentration. It could be explained by the fact that the interaction of those lipids with Zr 6 OTf-BTB is not Lewis acid–base interaction and possibly the dipolar interaction or ion exchange interaction (especially for DHA) that was weakened when more polar solvent formic acid was added or when the pH of the solvent got lower after adding formic acid.…”

Section: Resultsmentioning

confidence: 77%

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Lewis Acidic Metal–Organic Framework Assisted Ambient Liquid Extraction Mass Spectrometry Imaging for Enhancing the Coverage of Poorly Ionizable Lipids in Brain Tissue

Lv,

Zhao,

Long

et al. 2024

Anal. Chem.

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The spatial distribution of lipidomes in tissues is of great importance in studies of living processes, diseases, and therapies. Mass spectrometry imaging (MSI) has become a critical technique for spatial lipidomics. However, MSI of low-abundance or poorly ionizable lipids is still challenging because of the ion suppression from highabundance lipids. Here, a metal−organic framework (MOF) Zr 6 O 4 (OH) 4 (1,3,5-Tris(4carboxyphenyl) benzene) 2 (triflate) 6 (Zr 6 OTf-BTB) was prepared and used for selective on-tissue adsorption of phospholipids to reduce ion suppression from them to poorly ionizable lipids. The results show that Zr 6 OTf-BTB with strong Lewis acidic sites and a large specific surface area (647.9 m 2 •g −1 ) could selectively adsorb phospholipids under 1% FA-MeOH. Adsorption efficiencies of phospholipids are 88.4−144.9 times higher than those of other neutral lipids. Moreover, the adsorption capacity and the adsorption kinetic rate constant of the new material to phospholipids are higher than those of Zr 6 -BTB (242.72 vs 73.96 mg•g −1 , 0.0442 vs 0.0220 g•mg −1 •min −1 ). A Zr 6 OTf-BTB sheet was prepared by a lamination technique for on-tissue phospholipid adsorption from brain tissue. Then, the tissue section on the Zr 6 OTf-BTB sheet was directly imaged via ambient liquid extraction-MSI with 1% FA-MeOH as the sampling solvent. The results showed that phospholipids could be 100% removed directly on tissue, and the detection coverage of the Zr 6 OTf-BTB-enhanced MSI method to ceramides (Cers) and hexosylceramides (HexCers) was increased by 5−26 times compared with direct tissue MSI (26 vs 1 and 17 vs 3). The new method provides an efficient and convenient way to eliminate the ion suppression from phospholipids in MSI, largely improving the detection coverage of low-abundance and poorly ionizable lipids.

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Section: Resultssupporting

confidence: 85%

Section: Resultsmentioning

confidence: 77%

Lewis Acidic Metal–Organic Framework Assisted Ambient Liquid Extraction Mass Spectrometry Imaging for Enhancing the Coverage of Poorly Ionizable Lipids in Brain Tissue

Lv,

Zhao,

Long

et al. 2024

Anal. Chem.

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“…The FTIR spectra also represented the chemical bonds that existed in NMPC ( Figure 1 a (ii)), resulting from the phosphorylation of chitosan. The NMPC spectra showed the O–H and N–H stretching bands at 3500–3200 cm −1 broadened, implying the substitution of –CH 2 PO 3 H 2 by the H atoms in the amine groups and affecting the hydrogen bonds [ 12 , 40 ]. The amine deformation peaks shifted to lower frequencies, from 1643 cm −1 and 1548 cm −1 in chitosan to 1632 cm −1 (antisymmetric deformation) and 1536 cm −1 (symmetric deformation) in NMPC; this result indicated the protonation of the chitosan amine as there was a hydrogen substitution to the methylene phosphonic groups that made it a tertiary amine and involved both peaks attributed to NH 3 + groups [ 12 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

Hybrid Composite Membrane of Phosphorylated Chitosan/Poly (Vinyl Alcohol)/Silica as a Proton Exchange Membrane

et al. 2021

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Chitosan is one of the natural biopolymers that has been studied as an alternative material to replace Nafion membranes as proton change membranes. Nevertheless, unmodified chitosan membranes have limitations including low proton conductivity and mechanical stability. The aim of this work is to study the effect of modifying chitosan through polymer blending with different compositions and the addition of inorganic filler on the microstructure and physical properties of N-methylene phosphonic chitosan/poly (vinyl alcohol) (NMPC/PVA) composite membranes. In this work, the NMPC biopolymer and PVA polymer are used as host polymers to produce NMPC/PVA composite membranes with different compositions (30–70% NMPC content). Increasing NMPC content in the membranes increases their proton conductivity, and as NMPC/PVA-50 composite membrane demonstrates the highest conductivity (8.76 × 10−5 S cm−1 at room temperature), it is chosen to be the base membrane for modification by adding hygroscopic silicon dioxide (SiO2) filler into its membrane matrix. The loading of SiO2 filler is varied (0.5–10 wt.%) to study the influence of filler concentration on temperature-dependent proton conductivity of membranes. NMPC/PVA-SiO2 (4 wt.%) exhibits the highest proton conductivity of 5.08 × 10−4 S cm−1 at 100 °C. In conclusion, the study shows that chitosan can be modified to produce proton exchange membranes that demonstrate enhanced properties and performance with the addition of PVA and SiO2.

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“…Chitosan, ß-(1 → 4) D-glucosamine, is a cationic amino polysaccharide which is a partly deacetylated form of chitin (extracting from the waste of exoskeleton of shrimp) [5]. Chitosan has been interested in medicine, pharmaceutical, biomedical, biological, agriculture, environment and in food technology such as, food formulations, binding, thickening, gelling, stabilizing, clarifying, antimicrobial and antioxidant agent [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Different Chemical and Physical Processing on the Physicochemical and Functional Characterization of Chitosan Extracted from Shrimp Waste Species of Indian White Shrimp

Nouri

Khodaiyan

Razavi

et al. 2016

Progress in Rubber, Plastics and Recycling Technology

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The preparation and characterization of chitosan, water soluble polysaccharide, from waste of Indian white shrimp (penaeus indicus) are reported. The effect of different conditions of chemical and physical methods on extraction, physiochemical (proximate composition, solubility, degree of deacetylation and molecular weight) and functional properties (fat binding capacity, water binding capacity and color attributes) of biopolymer chitosan was examined. The results suggested that optimal condition preparation involves alkali concentration of 50%, a power of microwave of 720 W and a reaction time of 20 S. The end product had a white color, high degree of deacetylation, solubility and low molecular weight, ash, protein and moisture content.

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Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia–zirconia stationary phase

Cited by 9 publications

References 36 publications

Lewis Acidic Metal–Organic Framework Assisted Ambient Liquid Extraction Mass Spectrometry Imaging for Enhancing the Coverage of Poorly Ionizable Lipids in Brain Tissue

Lewis Acidic Metal–Organic Framework Assisted Ambient Liquid Extraction Mass Spectrometry Imaging for Enhancing the Coverage of Poorly Ionizable Lipids in Brain Tissue

Hybrid Composite Membrane of Phosphorylated Chitosan/Poly (Vinyl Alcohol)/Silica as a Proton Exchange Membrane

The Effect of Different Chemical and Physical Processing on the Physicochemical and Functional Characterization of Chitosan Extracted from Shrimp Waste Species of Indian White Shrimp

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