Preparation, characterization, and biologic evaluation of copper(II) – Schiff base complexes derived from anthranilic acid and aldoses

Iqbal, Mazhar; Khurshid, Syed Javaid; Iqbal, Mohammad

doi:10.1139/v93-083

Cited by 13 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Formation of Schiff base ligands was indicated by yellowing of solution and development of an absorption band with a maximum at 400 nm 27 in the visible region. It is known that Schiff bases obtained from aliphatic carbonyl compounds are readily hydrolyzed 28 . However these Schiff bases are isolated as metal chelates.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Spectral and Biological Studies of Novel Schiff Base Metal Complexes Derived from Cephalexin and Sugars

Naz¹,

Sadiq²,

Iqbal³

2013

Asian J. Chem.

View full text Add to dashboard Cite

The widely use of the antibiotics leads to the serious medical problem of drugs resistance and public health concern 1-4. Studies of new synthetic derivatives of antibiotics with novel mechanism of action has become an important chore to deal with drugs resistance dilemma 5-7. Literature suggests that some antibiotics showed improved activity when administered as metal complex rather than as simple organic molecule 8-11 and that the coordinating possibility of antibiotics has been improved by condensing with a variety of carbonyl compounds to make chemotherapeutic Schiff base metal complexes 12,13. Schiff bases are distinctive class of chelating ligands in coordination chemistry 14-16 and have diversity of applications in different fields 17,18 owing to its greater pick, sensitivity and synthetic flexibility to coordinate with different transition metal ions 19,20. In continuance 21,22 of our research work, we reported the synthesis, spectroscopic and biological studies of new schiff base derivatives of cephalexin with sugars and their Fe(II), Co(II) and Ni(II) metal complexes (Scheme-I). EXPERIMENTAL All the solvents and regents used for this study were of analytical grade and obtained from E. Merck. The Cephalexin was obtained from Remington Pharmaceutical Industries Pvt. Ltd.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis, Spectral and Biological Studies of Novel Schiff Base Metal Complexes Derived from Cephalexin and Sugars

Naz¹,

Sadiq²,

Iqbal³

2013

Asian J. Chem.

View full text Add to dashboard Cite

show abstract

“…On the other hand, the polymeric Co(II) and Cu(II) complexes were paramagnetic in nature. The Cu(II) complex showed a magnetic moment value of 1.91 BM, 43 a value close to the spin‐only value of 1.73 BM expected for an spin ( S ) = ½ system, whereas the magnetic moment value of the Co(II) complex was 2.6 BM; this generally arises from one unpaired electron and an apparently large orbital contribution and is also diagnostic of coordination geometry around a low‐spin, square‐planar Co(II) ion. 44…”

Section: Resultsmentioning

confidence: 99%

Selective oxidation of olefins and aromatic alcohols with tert‐butylhydroperoxide catalyzed by polymer‐anchored transition‐metal complexes

Roy

Mondal

et al. 2011

J of Applied Polymer Sci

View full text Add to dashboard Cite

Three polymer-anchored metal complexes (Co, Cu, and Pd) were synthesized and characterized. The catalytic performance of these complexes was tested for the oxidation of olefins and aromatic alcohols. These complexes showed excellent catalytic activity and high selectivity. These complexes selectively gave epoxides and aldehydes from olefins and alcohols, respectively. Individually, the effect of various solvents, oxidants, substrate oxidant molar ratios, temperatures, and catalyst amounts for the oxidation of cyclohexene and benzyl alcohol were studied. Under optimized reaction conditions, 96, 81, and 71% conversions of cyclohexene and 86, 79, and 73% conversions of benzyl alcohol were obtained with Co(II), Cu(II), and Pd(II) catalysts, respectively. The catalytic results reveal that these complexes could be recycled more than five times without much loss in activity.

show abstract

“…The Cu(II) complex shows a magnetic moment value of 1.88 B.M. [25], a value close to the spin-only value of 1.73 B.M., expected for S = system, while the magnetic moment value of the Co(II) complex is 2.76 B.M., which is generally arising from one unpaired electron and an apparently large orbital contribution and also diagnostic of the geometry around the low-spin tetracoordinated Co(II) atom [26]. The magnetic moment values of the Fe(III) and Mn(II) complexes support the formation of high-spin octahedral geometry [27].…”

Section: Resultsmentioning

confidence: 99%

Synthesis, characterization and catalytic activity of polymer anchored transition metal complexes toward oxidation reactions

Mondal

Tuhina²,

Roy

et al. 2010

Transition Met Chem

View full text Add to dashboard Cite

The polymer-anchored Schiff base complexes of Cu(II), Co(II), Ni(II), Mn(II) and Fe(III) were prepared by reacting polystyrene amine with 2-pyridinecarbaldehyde followed by loading of metal atom in methanol. These complexes were characterized by using different physicochemical and spectroscopic methods. The catalytic activity of these polymer-supported metal catalysts was tested for the oxidation of various olefins and alcohols. Influence of various reaction parameters, such as reaction temperature, reaction time, oxidant, substrate-to-oxidant mole ratio and nature of solvent, was studied for the oxidation of cyclohexene with these catalysts. Among the catalysts studied, Cu-Cat showed higher catalytic activity toward oxidation reactions than the other catalysts. Moreover, hot filtration experiments proved that these catalysts are truly heterogeneous and can be reused a number of times without significant loss of activity.

show abstract

Preparation, characterization, and biologic evaluation of copper(II) – Schiff base complexes derived from anthranilic acid and aldoses

Cited by 13 publications

References 9 publications

Synthesis, Spectral and Biological Studies of Novel Schiff Base Metal Complexes Derived from Cephalexin and Sugars

Synthesis, Spectral and Biological Studies of Novel Schiff Base Metal Complexes Derived from Cephalexin and Sugars

Selective oxidation of olefins and aromatic alcohols with tert‐butylhydroperoxide catalyzed by polymer‐anchored transition‐metal complexes

Synthesis, characterization and catalytic activity of polymer anchored transition metal complexes toward oxidation reactions

Contact Info

Product

Resources

About