Preparation, characterization and biological studies of some novel ferrocenyl compounds

Abd-Elzaher, Mokhles M.; Ali, Imran

doi:10.1002/aoc.1016

Cited by 21 publications

(6 citation statements)

References 39 publications

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“…2 In most cases, dendrimers serve as carriers of biologically active agents by encapsulating them in the interior or, more often, tethering them on the periphery of the dendrimers. For example, most dendrimers displaying antimicrobial activities are terminated with antimicrobial agents, including ferrocene, 3 quaternary ammonium, 2,4 boron complexes, 5 carbohydrates, 6 and peptides. 7 Poly(amidoamine) (PAMAM) dendrimers (e.g., the generation 3 (G3) PAMAM in Figure 1) are the most extensively studied dendrimers.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activities of Poly(amidoamine) Dendrimers Terminated with Amino and Poly(ethylene glycol) Groups

et al. 2007

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Poly(amidoamine) (PAMAM) dendrimer derivatives have been investigated for their biological applications, especially for delivery of drugs, including antimicrobial drugs to eukaryotic cells, but their effects on bacterial cells are largely unexplored. Herein we report that amino-terminated PAMAM dendrimers are highly toxic to the common Gram-negative pathogen Pseudomonas aeruginosa. The concentration that kills 50% of the bacteria (EC50) was in the range of approximately 0.9-1.5 microg/mL for the generation 5, amino-terminated dendrimers with or without partial (43%) coating of poly(ethylene glycol) (PEG). These EC50 values were lower than that ( approximately 1.9-2.8 microg/mL) for LL-37, a potent antimicrobial peptide expressed in a variety of epithelia. On the contrary, the dendrimers were far less toxic (EC50 > 21 microg/mL) to the Gram-positive pathogen Staphylococcus aureus than LL-37 (EC50 = approximately 1.9 microg/mL). In agreement with the previous studies on other cell types, the dendrimers were not cytotoxic to human corneal epithelial cells at the concentrations that were toxic to P. aeruginosa. Our findings indicate that amino-terminated PAMAM dendrimers and their partially PEG-coated derivatives possess attractive antimicrobial properties, particularly against Gram-negative bacteria, thus expanding the potential biological application of the dendrimers.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activities of Poly(amidoamine) Dendrimers Terminated with Amino and Poly(ethylene glycol) Groups

et al. 2007

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“…Ferrocene is nontoxic and has a unique structure as well as an excellent redox property, allowing wide applications in medicinal chemistry. These interesting applications of ferrocenyl compounds resulted in several reports of hetero-bimetallic complexes [14][15][16][17], since some ferrocenyl complexes showed enhanced biological activity compared to parent ligand. The aim of this work is to prepare a series of lanthanide complexes with two ferrocenyl ligands and to characterize the structure of these complexes.…”

Section: Introductionmentioning

confidence: 99%

New lanthanide complexes of 1,1`-bis[(2-thienylmethylidene)hydrazono-1-ethyl]-ferrocene and 1,1`-bis(2,3-dihydro-2-methylbenzo[d]thiazol-2-yl)ferrocene: Synthesis, characterization and antimicrobial properties

Hegazy

2013

Eur. J. Chem.

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“…Divalent transition metal complexes of the hexadentate ligands were reported classically in many studies [7][8][9][10][11][12] . Use of metal complexes in biological (antibacterial, antimicrobial) and medicinal chemistry (anticancer) has been growing rapidly in recent years [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] .…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activities of Newly Synthesized Co(II), Ni(II) and Cu(II) Complexes with Hexadentate Hydrazonic Ligands

2013

Chem Sci Trans

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In this paper, we report the synthesis, characterization and antitumor studies of Co(II), Ni(II) and Cu(II) complexes with two potentially hexadentate ligands. Antitumor activity of the prepared ligands and its complexes against human breast cancer cell line MCF-7 was determined. The level of total protein, nucleic acids (RNA and DNA) and nitric oxide (NO) in MCF-7 treated cells was estimated. Antitumor activities of the complexes are accompanied with overproduction of free and superoxide radicals allowed reactive oxygen species-mediated tumor cell death. The results show significant antitumor activity comparable to cisplatin

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Preparation, characterization and biological studies of some novel ferrocenyl compounds

Cited by 21 publications

References 39 publications

Antibacterial Activities of Poly(amidoamine) Dendrimers Terminated with Amino and Poly(ethylene glycol) Groups

Antibacterial Activities of Poly(amidoamine) Dendrimers Terminated with Amino and Poly(ethylene glycol) Groups

New lanthanide complexes of 1,1`-bis[(2-thienylmethylidene)hydrazono-1-ethyl]-ferrocene and 1,1`-bis(2,3-dihydro-2-methylbenzo[d]thiazol-2-yl)ferrocene: Synthesis, characterization and antimicrobial properties

Cytotoxic Activities of Newly Synthesized Co(II), Ni(II) and Cu(II) Complexes with Hexadentate Hydrazonic Ligands

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