Preparation,characterization and content determination of cubic phase gel containing capsaicin

Peng, Xinsheng; Yang, Zhiwen; Chen, Meiwan; Han, Ke; Xiao, Yujun; Wu, Chuanbin

doi:10.4268/cjcmm20102306

Cited by 3 publications

(1 citation statement)

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“…Yet capsaicin is actually irritant to human skin producing a burning sensation [2], and because of its high degree of first-pass metabolism in gastric intestinal track and short half-life by intravenous administration (7.06 min) [3, 4], transdermal delivery system seems to be more advantageous for capsaicin. In our previous research, we chose cataplasm [5], cubic phase gel [6, 7], and cubosome [8, 9] as transdermal delivery system providing the sustained release for capsaicin.…”

Section: Introductionmentioning

confidence: 99%

Development of a HPLC Method for the Quantitative Determination of Capsaicin in Collagen Sponge

Guo

Chen

Cui

et al. 2015

International Journal of Analytical Chemistry

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Controlling the concentration of drugs in pharmaceutical products is essential to patient's safety. In this study, a simple and sensitive HPLC method is developed to quantitatively analyze capsaicin in collagen sponge. The capsaicin from sponge was extracted for 30 min with ultrasonic wave extraction technique and methanol was used as solvent. The chromatographic method was performed by using isocratic system composed of acetonitrile-water (70 : 30) with a flow rate of 1 mL/min and the detection wavelength was at 280 nm. Capsaicin can be successfully separated with good linearity (the regression equation is A = 9.7182C + 0.8547; R 2 = 1.0) and perfect recovery (99.72%). The mean capsaicin concentration in collagen sponge was 49.32 mg/g (RSD = 1.30%; n = 3). In conclusion, the ultrasonic wave extraction method is simple and the extracting efficiency is high. The HPLC assay has excellent sensitivity and specificity and is a convenient method for capsaicin detection in collagen sponge. This paper firstly discusses the quantitative analysis of capsaicin in collagen sponge.

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Section: Introductionmentioning

confidence: 99%

Development of a HPLC Method for the Quantitative Determination of Capsaicin in Collagen Sponge

Guo

Chen

Cui

et al. 2015

International Journal of Analytical Chemistry

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Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol

Zhu

et al. 2015

Med Sci Monit

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BackgroundThe aim of this study was to optimize the preparation method for self-assembled glyceryl monoolein-based cubosomes containing paeonol and to characterize the properties of this transdermal delivery system to improve the drug penetration ability in the skin.Material/MethodsIn this study, the cubic liquid crystalline nanoparticles loaded with paeonol were prepared by fragmentation of glyceryl monoolein (GMO)/poloxamer 407 bulk cubic gel by high-pressure homogenization. We evaluated the Zeta potential of these promising skin-targeting drug-delivery systems using the Malvern Zeta sizer examination, and various microscopies and differential scanning calorimetry were also used for property investigation. Stimulating studies were evaluated based on the skin irritation reaction score standard and the skin stimulus intensity evaluation standard for paeonol cubosomes when compared with commercial paeonol ointment. In vitro tests were performed on excised rat skins in an improved Franz diffusion apparatus. The amount of paeonol over time in the in vitro penetration and retention experiments both was determined quantitatively by HPLC.ResultsStimulating studies were compared with the commercial ointment which indicated that the paeonol cubic liquid crystalline nanoparticles could reduce the irritation in the skin stimulating test. Thus, based on the attractive characteristics of the cubic crystal system of paeonol, we will further exploit the cosmetic features in the future studies.ConclusionsThe transdermal delivery system of paeonol with low-irritation based on the self-assembled cubic liquid crystalline nanoparticles prepared in this study might be a promising system of good tropical preparation for skin application.

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Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin

Peng¹,

Zhou²,

Han³

et al. 2015

DDDT

102

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Phytantriol- and glycerol monooleate-based cubosomes were produced and characterized as a targeted and sustained transdermal delivery system for capsaicin. The cubosomes were prepared by emulsification and homogenization of phytantriol (F1), glycerol monooleate (F2), and poloxamer dispersions, characterized for morphology and particle size distribution by transmission electron microscope and photon correlation spectroscopy. Their Im3m crystallographic space group was confirmed by small-angle X-ray scattering. An in vitro release study showed that the cubosomes provided a sustained release system for capsaicin. An in vitro diffusion study conducted using Franz diffusion cells indicated that the skin retention of capsaicin from cubosomes in the stratum corneum was much higher (2.75±0.22 μg versus 4.32±0.13 μg, respectively) than that of capsaicin cream (0.72±0.13 μg). The stress testing showed that the cubosome formulations were stable under strong light and high temperature for up to 10 days. After multiapplications on mouse skin, the irritation of capsaicin cubosomes and cream was light with the least amount of side effects. Overall, the present study demonstrated that cubosomes may be a suitable skin-targeted and sustained delivery system for the transdermal administration of capsaicin.

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Preparation,characterization and content determination of cubic phase gel containing capsaicin

Cited by 3 publications

References 0 publications

Development of a HPLC Method for the Quantitative Determination of Capsaicin in Collagen Sponge

Development of a HPLC Method for the Quantitative Determination of Capsaicin in Collagen Sponge

Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol

Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin

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