Preparation, Characterization and Evaluation of the Anti-Inflammatory Activity of Epichlorohydrin-β-Cyclodextrin/Curcumin Binary Systems Embedded in a Pluronic®/Hyaluronate Hydrogel

Fernández-Romero, Ana-María; Maestrelli, Francesca; García-Gil, Sara; Talero, Elena; Mura, Paola; Rabasco, A. M.; González-Rodrı́guez, Marı́a Luisa

doi:10.3390/ijms222413566

Cited by 12 publications

(6 citation statements)

References 79 publications

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“…Curcumin encapsulation in epichlorohydrin-β-cyclodextrin and hydrogel system formation resulted in improved curcumin activity, such as skin penetration and release pattern. Moreover, the conjugate exhibited anti-inflammatory properties (IL-6 in HaCaT cells increased compared to the control) [74]. The desirable properties, such as deeper penetration, better skin hydration, curcumin dispersion, and stable release were also reported when the hydrogel system contained nanoparticle-entrapped curcumin, confirmed by in vitro and in vivo studies.…”

Section: Skin Diseasesmentioning

confidence: 63%

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Stachowiak,

Mlynarczyk,

Dlugaszewska

2024

Molecules

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Curcumin is a natural compound with a great pharmaceutical potential that involves anticancer, anti-inflammatory, antioxidant, and neuroprotective activity. Unfortunately, its low bioavailability, instability, and poor water solubility significantly deteriorate its clinical use. Many attempts have been made to overcome this issue, and encapsulating curcumin in a hydrogel matrix may improve those properties. Hydrogel formulation is used in many drug delivery forms, including classic types and novel forms such as self-assembly systems or responsive to external factors. Reviewed studies confirmed better properties of hydrogel-stabilized curcumin in comparison to pure compound. The main enhanced characteristics were chemical stability, bioavailability, and water solubility, which enabled these systems to be tested for various diseases. These formulations were evaluated for wound healing properties, effectiveness in treating skin diseases, and anticancer and regenerative activity. Hydrogel formulation significantly improved biopharmaceutical properties, opening the opportunity to finally see curcumin as a clinically approved substance and unravel its therapeutic potential.

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Section: Skin Diseasesmentioning

confidence: 63%

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Stachowiak,

Mlynarczyk,

Dlugaszewska

2024

Molecules

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“… [ 127 ] Epichlorohydrin-β-CD, pluronic ® F-127/hyaluronate hydrogel - - Curcumin - It exhibited notable solubility and a substantial decrease in IL-6 levels. [ 128 ] Choline-calixarene 1 46 nm - Curcumin BALB/c mice It displayed negligible toxicity while demonstrating an anti-psoriatic effect in a psoriasis model, achieved by mitigating the pro-inflammatory process. [ 129 ] Cholesterol, span 20, span 60, carbopol powder 133 nm Thin-film hydration, sonication Celastrol C57/BL6 mice It attained its anti-psoriatic effect by inhibiting inflammation and hyperproliferation of keratinocytes in the skin while further suppressing systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Recent Advancements and Trends of Topical Drug Delivery Systems in Psoriasis: A Review and Bibliometric Analysis

An,

Zhao,

Hao

et al. 2024

IJN

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Psoriasis is an immune-mediated inflammatory skin disease where topical therapy is crucial. While various dosage forms have enhanced the efficacy of current treatments, their limited permeability and lack of targeted delivery to the dermis and epidermis remain challenges. We reviewed the evolution of topical therapies for psoriasis and conducted a bibliometric analysis from 1993 to 2023 using a predictive linear regression model. This included a comprehensive statistical and visual evaluation of each model’s validity, literature profiles, citation patterns, and collaborations, assessing R variance and mean squared error (MSE). Furthermore, we detailed the structural features and penetration pathways of emerging drug delivery systems for topical treatment, such as lipid-based, polymer-based, metallic nanocarriers, and nanocrystals, highlighting their advantages. This systematic overview indicates that future research should focus on developing novel drug delivery systems characterized by enhanced stability, biocompatibility, and drug-carrying capacity.

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“…Indeed, the use of CDs to complex polyphenols has already been reported with encouraging repercussions [107][108][109][110][111][112]. Moreover, taking advantage of sustainable green chemistry, CDs have been demonstrated to be promising contributors to the extraction of polyphenols [113][114][115].…”

Section: Polyphenolsmentioning

confidence: 99%

The Role of Cyclodextrins in COVID-19 Therapy—A Literature Review

Almeida

Domingues

Mascarenhas-Melo

et al. 2023

IJMS

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Coronavirus disease-19 (COVID-19) emerged in December 2019 and quickly spread, giving rise to a pandemic crisis. Therefore, it triggered tireless efforts to identify the mechanisms of the disease, how to prevent and treat it, and to limit and hamper its global dissemination. Considering the above, the search for prophylactic approaches has led to a revolution in the reglementary pharmaceutical pipeline, with the approval of vaccines against COVID-19 in an unprecedented way. Moreover, a drug repurposing scheme using regulatory-approved antiretroviral agents is also being pursued. However, their physicochemical characteristics or reported adverse events have sometimes limited their use. Hence, nanotechnology has been employed to potentially overcome some of these challenges, particularly cyclodextrins. Cyclodextrins are cyclic oligosaccharides that present hydrophobic cavities suitable for complexing several drugs. This review, besides presenting studies on the inclusion of antiviral drugs in cyclodextrins, aims to summarize some currently available prophylactic and therapeutic schemes against COVID-19, highlighting those that already make use of cyclodextrins for their complexation. In addition, some new therapeutic approaches are underscored, and the potential application of cyclodextrins to increase their promising application against COVID-19 will be addressed. This review describes the instances in which the use of cyclodextrins promotes increased bioavailability, antiviral action, and the solubility of the drugs under analysis. The potential use of cyclodextrins as an active ingredient is also covered. Finally, toxicity and regulatory issues as well as future perspectives regarding the use of cyclodextrins in COVID-19 therapy will be provided.

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Preparation, Characterization and Evaluation of the Anti-Inflammatory Activity of Epichlorohydrin-β-Cyclodextrin/Curcumin Binary Systems Embedded in a Pluronic®/Hyaluronate Hydrogel

Cited by 12 publications

References 79 publications

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Recent Advancements and Trends of Topical Drug Delivery Systems in Psoriasis: A Review and Bibliometric Analysis

The Role of Cyclodextrins in COVID-19 Therapy—A Literature Review

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