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NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://doi.org/10.1021/acs.biomac.6b00040Access and use of this website and the material on it are subject to the Terms and Conditions set forth at pH-triggered release of hydrophobic molecules from self-assembling hybrid nanoscaffolds Lu, Lei; Unsworth, Larry D.http://nparc.cisti-icist.nrc-cnrc.gc.ca/fra/droits L'accès à ce site Web et l'utilisation de son contenu sont assujettis aux conditions présentées dans le site LISEZ CES CONDITIONS ATTENTIVEMENT AVANT D'UTILISER CE SITE WEB.
NRC Publications Record / Notice d'Archives des publications de CNRC:http://nparc.cisti-icist.nrc-cnrc.gc.ca/eng/view/object/?id=9e4287db-e138-42bd-a2f4-805f4418351b http://nparc.cisti-icist.nrc-cnrc.gc.ca/fra/voir/objet/?id=9e4287db-e138-42bd-a2f4-805f4418351b pH-Triggered Release of Hydrophobic Molecules from SelfAssembling Hybrid Nanoscaffolds Lei Lu †, ‡ and Larry D. Unsworth* , †, ‡ † Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada ‡ National Institute for Nanotechnology, National Research Council (Canada), Edmonton, Alberta T6G 2M9, Canada * S Supporting Information ABSTRACT: Self-assembling peptide based hydrogels have a wide range of applications in the field of tissue repair and tissue regeneration. Because of its physicochemical properties, (RADA) 4 has been studied as a potential platform for 3D cell culture, drug delivery, and tissue engineering. Despite some small molecule and protein release studies with this system, there is a lack of work investigating the controlled release of hydrophobic compounds (i.e., anti-inflammatory, anticancer, antibacterial drugs, etc.) that are important for many clinical therapies. Attempts to incorporate hydrophobic compounds into self-assembling matrices usually inhibited nanofiber formation, rather resulting in a peptide−drug complex or microcrystal formation. Herein, a selfassembling chitosan/carboxymethyl-β-cyclodextrin nanoparticle system was used to load dexamethasone, which formed within a self-assembling (RADA...