Preparation,	Characterization	and	In-Vitro	Cytotoxic	Study	of	Doxorubicin	PLGA Nanoparticles

Parashar, Bharat; Sharma, Sourabh

doi:10.20510/ukjpb/1/i1/91120

Cited by 2 publications

(1 citation statement)

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“…The antimicrobial effect of Ag+ ions has been well documented and it has been applied [78,79]. We are interested to investigate the potential of antibacterial activity of biologically synthesized AgNPs against H. pylori and H. felis.…”

Section: Dose-dependent Antibacterial Effects Of Agnpsmentioning

confidence: 99%

Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells

Gurunathan¹,

Jeong²,

Han³

et al. 2016

Nano Online

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Silver nanoparticles (AgNPs) are prominent group of nanomaterials and are recognized for their diverse applications in various health sectors. This study aimed to synthesize the AgNPs using the leaf extract of Artemisia princeps as a bio-reductant. Furthermore, we evaluated the multidimensional effect of the biologically synthesized AgNPs in Helicobacter pylori , Helicobacter felis , and human lung (L132) and lung carcinoma (A549) cells. UV-visible (UV-vis) spectroscopy confirmed the synthesis of AgNPs. X-ray diffraction (XRD) indicated that the AgNPs are specifically indexed to a crystal structure. The results from Fourier transform infrared spectroscopy (FTIR) indicate that biomolecules are involved in the synthesis and stabilization of AgNPs. Dynamic light scattering (DLS) studies showed the average size distribution of the particle between 10 and 40 nm, and transmission electron microscopy (TEM) confirmed that the AgNPs were significantly well separated and spherical with an average size of 20 nm. AgNPs caused dose-dependent decrease in cell viability and biofilm formation and increase in reactive oxygen species (ROS) generation and DNA fragmentation in H. pylori and H. felis. Furthermore, AgNPs induced mitochondrial-mediated apoptosis in A549 cells; conversely, AgNPs had no significant effects on L132 cells. The results from this study suggest that AgNPs could cause cell-specific apoptosis in mammalian cells. Our findings demonstrate that this environmentally friendly method for the synthesis of AgNPs and that the prepared AgNPs have multidimensional effects such as anti-bacterial and anti-biofilm activity against H. pylori and H. felis and also cytotoxic effects against human cancer cells. This report describes comprehensively the effects of AgNPs on bacteria and mammalian cells. We believe that biologically synthesized AgNPs will open a new avenue towards various biotechnological and biomedical applications in the near future.

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Section: Dose-dependent Antibacterial Effects Of Agnpsmentioning

confidence: 99%

Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells

Gurunathan¹,

Jeong²,

Han³

et al. 2016

Nano Online

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Green Synthesis of Zinc Nanowires using Spilanthes acmella Leaf Extract

Paul¹,

Khole²,

Jagtap³

et al. 2016

PBJ

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Biogenic synthesis of metal nanomaterials has garnered attention in current nanobiotechnology. Among other metal nanoparticles, zinc nanoparticles have gained importance due to their applications in diverse fields. In this paper, we report on the biological synthesis of zinc nanowires using Spilanthes acmella leaves extract as a reducing agent. Synthesized nanoparticles have been confirmed by Transmission Electron Microscopy(TEM). The characterization revealed the wire shape of zinc nanoparticles.

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Preparation, Characterization and In-Vitro Cytotoxic Study of Doxorubicin PLGA Nanoparticles

Cited by 2 publications

References 0 publications

Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells

Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells

Green Synthesis of Zinc Nanowires using Spilanthes acmella Leaf Extract

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