Preparation, characterization and in vivo pharmacokinetic evaluation of curcuminoids-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs)

Dolatabadi, Shabnam; Karimi, Maryam; Nasirizadeh, Samira; Hatamipour, Mahdi; Golmohammadzadeh, Shiva; Jaafari, Mahmoud Reza

doi:10.1016/j.jddst.2021.102352

Cited by 40 publications

(20 citation statements)

References 44 publications

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“…The results showed that the DMC loaded nanoparticles exhibited a particle size of 75.55 ± 0.51 nm with a PDI of 0.281 ± 0.014 and the BDM nanoparticles 15.13 ± 0.014 nm with a PDI of 0.196 ± 0.032. A formulation composed of Chol, lecitin and vitamin E TPGS reports a BDM-loaded PLHNs size of 75.98 nm [ 57 ] while Dolatabi et al [ 58 ] reported a DMC PLHNs formulation with Precirol ® ATO5 and polaxamer 188 with a-size of 160.7 nm. Our findings indicate smaller particle sizes than both studies and a similar average size of (a-size) <50 nm for BDM in a PLHNs formulation with ethyl oleate and PEG-400 [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

Design of Hybrid Polymeric-Lipid Nanoparticles Using Curcumin as a Model: Preparation, Characterization, and In Vitro Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin-Loaded Nanoparticles

et al. 2021

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Polymeric lipid hybrid nanoparticles (PLHNs) are the new generation of drug delivery systems that has emerged as a combination of a polymeric core and lipid shell. We designed and optimized a simple method for the preparation of Pluronic F-127-based PLHNs able to load separately demethoxycurcumin (DMC) and bisdemethoycurcumin (BDM). CUR was used as a model compound due to its greater availability from turmeric and its structure similarity with DMC and BDM. The developed method produced DMC and BDM-loaded PLHNs with a size average of 75.55 ± 0.51 and 15.13 ± 0.014 nm for DMC and BDM, respectively. An FT-IR analysis confirmed the encapsulation and TEM images showed their spherical shape. Both formulations achieved an encapsulation efficiency ≥ 92% and an exhibited significantly increased release from the PLHN compared with free compounds in water. The antioxidant activity was enhanced as well, in agreement with the improvement in water dissolution; obtaining IC50 values of 12.74 ± 0.09 and 16.03 ± 0.55 for DMC and BDM-loaded PLHNs, respectively, while free curcuminoids exhibited considerably lower antioxidant values in an aqueous solution. Hence, the optimized PHLN synthesis method using CUR as a model and then successfully applied to obtain DMC and BDM-loaded PLHNs can be extended to curcuminoids and molecules with a similar backbone structure to improve their bioactivities.

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Section: Resultsmentioning

confidence: 99%

Design of Hybrid Polymeric-Lipid Nanoparticles Using Curcumin as a Model: Preparation, Characterization, and In Vitro Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin-Loaded Nanoparticles

et al. 2021

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“…100-400 healthy subjects/patients 3. 1,000-5,000 healthy subjects/patients Commercial product Phase IV Commercialization T = 0 Pharma industries Pharma industries lipid-based Cur formulations (Dolatabadi et al, 2021), and inorganicbased Cur formulations (Pote et al, 2021). In this regard, a variety of techniques have been developed for nano-Cur synthesis.…”

Section: How Nano-cur Affects Its Biological and Pharmacological Activities?mentioning

confidence: 99%

“…Recently, different types of Cur nanoparticles have been developed for the treatment of various diseases. These Cur nanoparticles can be classified into three types, including polymeric‐based Cur formulations (Bagheri et al, 2021), lipid‐based Cur formulations (Dolatabadi et al, 2021), and inorganic‐based Cur formulations (Pote et al, 2021). In this regard, a variety of techniques have been developed for nano‐Cur synthesis.…”

Section: How Nano‐cur Affects Its Biological and Pharmacological Acti...mentioning

confidence: 99%

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Khezri

Saeedi

Mohammadamini

et al. 2021

Phytotherapy Research

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Today, due to the prevalence of various diseases such as the novel coronavirus (SARS-CoV-2), diabetes, central nervous system diseases, cancer, cardiovascular disorders, and so on, extensive studies have been conducted on therapeutic properties of natural and synthetic agents. A literature review on herbal medicine and commercial products in the global market showed that curcumin (Cur) has many therapeutic benefits compared to other natural ingredients. Despite the unique properties of Cur, its use in clinical trials is very limited. The poor biopharmaceutical properties of Cur such as short half-life in plasma, low bioavailability, poor absorption, rapid metabolism, very low solubility (at acidic and physiological pH), and the chemical instability in body fluids are major concerns associated with the clinical applications of Cur.Recently, nanoformulations are emerging as approaches to develop and improve the therapeutic efficacy of various drugs. Many studies have shown that Cur nanoformulations have tremendous therapeutic potential against various diseases such as SARS-CoV-2, cancer, inflammatory, osteoporosis, and so on. These nanoformulations can inhibit many diseases through several cellular and molecular mechanisms. However, successful long-term clinical results are required to confirm their safety and clinical efficacy. The present review aims to update and explain the therapeutic potential of Cur nanoformulations.

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“…Liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs) are developed for efficient drug encapsulation and drug accumulation in the target tissue (Abbott, 2013), by providing drug stability and controlled release of the therapeutic molecules (Tapeinos et al, 2017). Among lipidbased nanovectors, NLCs have been developed during the last decade as advantageous tools with respect to more traditional liposomes and SLNs, since they present both solid and liquid lipids at physiological temperatures that provide a high level of flexibility, drug loading, and excellent biocompatibility and biodegradability (Dolatabadi et al, 2021). In particular, the high flexibility of the NLCs avoids drug leakage and improves nanovector diffusion capacity through the cell membrane (López-García and Ganem-Rondero, 2015), all features that make them suitable also for the delivery of antioxidant agents (Ahmadzadeh et al, 2020), including hazelnut extracts.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, the high flexibility of the NLCs avoids drug leakage and improves nanovector diffusion capacity through the cell membrane (López-García and Ganem-Rondero, 2015), all features that make them suitable also for the delivery of antioxidant agents (Ahmadzadeh et al, 2020), including hazelnut extracts. In the literature, NLCs have been proposed for the delivery of strong antioxidants such as resveratrol (Sen et al, 2021), curcuminoids (Dolatabadi et al, 2021), idebenone (Martinelli et al, 2020), and linoleic acid (Sadat et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Hazelnut extract-loaded nanostructured lipid carriers and evaluation of their antioxidant properties

Emanet

Şen

Pignatelli

et al. 2022

Front. Bioeng. Biotechnol.

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Reactive oxygen species (ROS) are a common hallmark of many degenerative diseases, developing in all those cases where a failure of physiological antioxidant mechanisms occurs (in particular, antioxidant enzymes and the glutathione system), or in case of exposure to an extremely high level of oxidants. In this regard, antioxidant natural extracts are promising compounds as preventive or therapeutic agents against ROS-dependent degenerations. In this study, a deep investigation of hazelnut (Corylus avellana) extract has been performed in terms of mass spectroscopy, evaluation of phenolic content, and antioxidant capacity. Then, nanostructured lipid carriers (NLCs) have been exploited for encapsulation of the hazelnut extracts in order to achieve prolonged bioactivity, increased stability, and targeting through a sustainable delivery approach. The hazelnut extract-loaded NLCs (NE_NLCs) have been deeply characterized for their stability, production yield, and encapsulation efficiency. Moreover, NE_NLCs showed optimal cytocompatibility on human dermal fibroblast (HDF) cells, as well as excellent antioxidant activity, upon pro-oxidant stimulus on HDF cells.

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Preparation, characterization and in vivo pharmacokinetic evaluation of curcuminoids-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs)

Cited by 40 publications

References 44 publications

Design of Hybrid Polymeric-Lipid Nanoparticles Using Curcumin as a Model: Preparation, Characterization, and In Vitro Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin-Loaded Nanoparticles

Design of Hybrid Polymeric-Lipid Nanoparticles Using Curcumin as a Model: Preparation, Characterization, and In Vitro Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin-Loaded Nanoparticles

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Hazelnut extract-loaded nanostructured lipid carriers and evaluation of their antioxidant properties

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