Preparation, Characterization and &lt;i&gt;in vivo &lt;/i&gt;Anti-inflammatory Studies of Ostrich Oil Based Nanoemulsion

Alshahrani, Saad

doi:10.5650/jos.ess18213

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…Particle size distribution and potential change are important indicators determining the emulsion stability. The size and charge of oil droplets in the microemulsion can directly affect the dispersibility of the hydrophobic bioactive substances in water phase, the transparency of the solution, and the release characteristics and availability in the animal body 49 . The particle size and potential of astaxanthin ester microcapsules recorded at 40 °C for 0 and 8 days are shown in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Stability and bioavailability of protein matrix‐encapsulated astaxanthin ester microcapsules

Yang

Cao

et al. 2021

J Sci Food Agric

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BACKGROUND Astaxanthin ester derived from Haematococcus pluvialis is often used as a functional and nutritional ingredient in foods. However, its utilization is currently limited as a result of its chemical instability and low bioavailability. Food matrix microcapsules are becoming increasingly popular because of their safety and high encapsulation efficiency. In the present study, the effect of protein matrixes on the properties of microcapsules was evaluated. RESULTS We investigated the effects of storage on astaxanthin ester microcapsules and the corresponding rehydration solution at 40 °C under a nitrogen atmosphere, as well as in darkness. The results showed that the stability of products prepared based on whey protein (WP) and corn‐gluten was superior to that of products prepared based on lactoferrin, soy protein and sodium caseinate. The bioavailability of astaxanthin ester microcapsules encapsulated with different proteins and examined by means of astaxanthin concentrations in the serum and liver after oral administration was compared. All five protein wall materials could significantly improve the bioavailability of astaxanthin ester. The microcapsules prepared based on WP had the highest bioavailability, with a value of 10.69 ± 0.75 μg·h mL−1, which was 3.15 times higher compared to that of the control group. CONCLUSION The results of the present study showed that protein encapsulation, especially WP encapsulation, could effectively improve the stability, water solubility and bioavailability of astaxanthin esters. Thus, WP can be used as the main wall material in delivery systems. © 2021 Society of Chemical Industry.

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Section: Resultsmentioning

confidence: 99%

Stability and bioavailability of protein matrix‐encapsulated astaxanthin ester microcapsules

Yang

Cao

et al. 2021

J Sci Food Agric

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“…Using the dynamic light scattering technique, droplet size in NE was determined by observing the fluctuation in light scattering related to Brownian motion. Before measurement, NE was diluted 100 times with distilled water and gently mixed (to promote homogeneity) [21].…”

Section: Droplet Size Measurement and Polydispersity Index (Pdi)mentioning

confidence: 99%

Topical Nanoemulsion-Based Gel of Isoconazole Nitrate

Mowafaq M. Ghareeb,

Mariam S. Mohammed

2023

AJPS

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This study aimed to make an o/wnanoemulsion of isoconazole the drugnitrate (ISN) for topical use. Low aqueous solubility is a characteristicfeature of the imidazole antifungal ISN. Therefore, ISN nanoemulsion would increase dispersibility and decreases skin resistance by enhancing the drug penetration to the first layers of skin (stratum corneum). The work included constructing the pseudo-ternary phase diagrams by using the aqueous titration method. The prepared o/w nanoemulsions were composed of oil, Smix (a mixture of surfactant and co-surfactant) and deionized water (DW). ISN nanoemulsions were subjected to characterization studies to choose the best formula. According to the characterization studies, the optimal formula, designated NE14 contains 1% ISN, 66% Smix ((1:3) tween60: propylene glycol:ethanol), 7% oleic acid, and 27% deionized water was reached. FormulaNE14 is characterized by having a polydispersity index of (0.146), pH (5.76), droplet size (84.6 nm), percent transmittance (98.8%), viscosity (80m Pa.s) and a high release of isoconazole propably due low viscosity. The droplet size of NE14 (84.6nm) was alsoconfirmed by an atomic force microscopy (AFM) research. The improved formula (ISN NE14) was found to be a promising nanoemulsion formula for enhancing the topical bioavailability of ISN and thus could increase its efficacy for the treatment of topical fungal infections.

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“…The droplet size of NE was established by analyzing the fluctuations in light scattering due to the Brownian motion of the particle utilizing dynamic light scattering technique (Zetasizer Nano ZS, Malvern, UK) (22) .…”

Section: Droplet Size Measurementmentioning

confidence: 99%

Formulation and Investigation of Lacidipine as a Nanoemulsions

Dahash¹,

Rajab²

2020

IJPS

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Many pharmaceutical molecules have solubility problems that until yet consist a hurdle that restricts their use in the pharmaceutical preparations. Lacidipine (LCDP) is a calcium-channel blocker with low aqueous solubility and bioavailability. Lipid dosage forms are attractive delivery systems for such hydrophobic drug molecules. Nanoemulsion (NE) is one of the popular methods that has been used to solve the solubility problems of many drugs. LCDP was formulated as a NE utilizing triacetin as an oil phase, tween 80 and tween 60 as a surfactant and ethanol as a co-surfactant. Nine formulas were prepared, and different tests performed to ensure the stability of the NEs, such as thermodynamic stability, particle size, Polydispersity index, zeta potential, dye solubility test, dilution test, drug content test and in-vitro drug release. Results of characterization showed that LCDP NE (F-5) with (oil: Smix (3:1):DDW (10:60:30)) ratio was selected as a best formula, since it have excellent thermodynamic stability with a particle size of 13.42, low PDI 0.234 , zeta potential (-14.5mV), efficient electrical conductivity 0.241ms/cm , good pH value (5.9), good percent of light transmittance (99.10%) , with acceptable viscosity , higher percent of drug content (99.14%) and complete release of the drug after (30 min.) with significantly higher (P<0.05) dissolution rate in comparison with pure drug powder. From the results obtained NE was found to be an efficient method to enhance the solubility and dissolution rate of drugs that have poor water solubility (lipophilic drugs).

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Preparation, Characterization and <i>in vivo </i>Anti-inflammatory Studies of Ostrich Oil Based Nanoemulsion

Cited by 9 publications

References 23 publications

Stability and bioavailability of protein matrix‐encapsulated astaxanthin ester microcapsules

Stability and bioavailability of protein matrix‐encapsulated astaxanthin ester microcapsules

Topical Nanoemulsion-Based Gel of Isoconazole Nitrate

Formulation and Investigation of Lacidipine as a Nanoemulsions

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